Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide

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dc.contributor.buuauthorGüleç, Güliz Uyar
dc.contributor.buuauthorNoyan, Behzat
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Bölümü.tr_TR
dc.date.accessioned2021-09-13T11:18:45Z
dc.date.available2021-09-13T11:18:45Z
dc.date.issued2001-02-28
dc.description.abstractThe aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions. Rat pups were exposed to single or multiple hyperthermic seizures. Subconvulsant doses of pilocarpine (100 mg/kg and 150 mg/kg) were injected intraperitoneally to these rats at 60-70 days of age. Also L-arginine was applied to some rats before a single hyperthermic seizure. We found that risk of future epilepsy increases parallel to the number of febrile convulsions and nitric oxide does not have a pathogenetic role at given doses.en_US
dc.identifier.citationGüleç, G. ve Noyan, B. (2002). "Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide". Developmental Brain Research, 126(2), 223-228.en_US
dc.identifier.endpage228tr_TR
dc.identifier.issn0165-3806
dc.identifier.issue2tr_TR
dc.identifier.pubmed11248357tr_TR
dc.identifier.scopus2-s2.0-0035961404tr_TR
dc.identifier.startpage223tr_TR
dc.identifier.urihttps://doi.org/10.1016/S0165-3806(01)00098-0
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0165380601000980
dc.identifier.urihttp://hdl.handle.net/11452/21905
dc.identifier.volume126tr_TR
dc.identifier.wos000167662900011
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.journalDevelopment Brain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPilocarpineen_US
dc.subjectRaten_US
dc.subjectSeizureen_US
dc.subjectSusceptibilityen_US
dc.subjectResistanten_US
dc.subjectHyperthermia-induced seizuresen_US
dc.subjectTemporal-lobe epilepsyen_US
dc.subjectStatus epilepticusen_US
dc.subjectLong-termen_US
dc.subjectRat susceptibilityen_US
dc.subjectChildhooden_US
dc.subjectGlutamateen_US
dc.subjectSystemen_US
dc.subject.meshHyperthermia, induceden_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginineen_US
dc.subject.meshBehavior, animalen_US
dc.subject.meshBody temperatureen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshDisease progressionen_US
dc.subject.meshDisease susceptibilityen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshElectroencephalographyen_US
dc.subject.meshEpilepsy, temporal lobeen_US
dc.subject.meshNitric oxideen_US
dc.subject.meshImmersionen_US
dc.subject.meshInjections, intraperitonealen_US
dc.subject.meshPilocarpineen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshReaction timeen_US
dc.subject.meshRisk assessmenten_US
dc.subject.meshSeizuresen_US
dc.subject.meshSeizures, febrileen_US
dc.subject.scopusFebrile Seizures; Status Epilepticus; Iron-Deficiency Anemiasen_US
dc.subject.wosDevelopmental biologyen_US
dc.subject.wosNeurosciencesen_US
dc.titleDo recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxideen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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