Antinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathy

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dc.contributor.buuauthorBağdaş, Deniz
dc.contributor.buuauthorÖzbölük, Hasret Yücel
dc.contributor.buuauthorÇinkılıç, Nilüfer
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Birimi.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.orcid0000-0002-3595-6286tr_TR
dc.contributor.researcheridAAG-8716-2019tr_TR
dc.contributor.researcheridAAH-5296-2021tr_TR
dc.contributor.scopusid15062425700en_US
dc.contributor.scopusid55890590200tr_TR
dc.contributor.scopusid26533892300tr_TR
dc.contributor.scopusid55664349700tr_TR
dc.date.accessioned2022-08-16T07:14:17Z
dc.date.available2022-08-16T07:14:17Z
dc.date.issued2014-06
dc.description.abstractThe present study aimed to evaluate possible antinociceptive effects of chlorogenic acid in streptozotocin-induced diabetic neuropathic pain in rats. Chlorogenic acid (100 mg/kg) was administered daily for 14 days. Our study showed for the first time that both single and chronic chlorogenic acid treatments produced significant antinociceptive effects in diabetic rats. In contrast, single dose of chlorogenic acid showed no signs of an antinociceptive effect, but chronic treatment exerted antinociceptive potential in nondiabetic rats. Additionally, chronic treatment effectively reduced hyperglycemia that induced by diabetes. In conclusion, chlorogenic acid has beneficial effects for the management of diabetic neuropathic pain.en_US
dc.identifier.citationBağdaş, D. vd. (2014). "Antinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathy". Journal of Medicinal Food, 17(6), 730-732.en_US
dc.identifier.endpage732tr_TR
dc.identifier.issn1096-620X
dc.identifier.issn1557-7600
dc.identifier.issue6tr_TR
dc.identifier.pubmed24611441tr_TR
dc.identifier.scopus2-s2.0-84902441455tr_TR
dc.identifier.startpage730tr_TR
dc.identifier.urihttps://doi.org/10.1089/jmf.2013.2966
dc.identifier.urihttps://www.liebertpub.com/doi/10.1089/jmf.2013.2966?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.identifier.urihttp://hdl.handle.net/11452/28192
dc.identifier.volume17tr_TR
dc.identifier.wos000337903500014tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherMary Ann Lieberten_US
dc.relation.journalJournal of Medicinal Fooden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntihyperalgesicen_US
dc.subjectAntinociceptiveen_US
dc.subjectChlorogenic aciden_US
dc.subjectDiabetesen_US
dc.subjectDiabetic neuropathyen_US
dc.subjectPainen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectFood science & technologyen_US
dc.subjectNutrition & dieteticsen_US
dc.subject.emtreeChlorogenic aciden_US
dc.subject.emtreeGlucoseen_US
dc.subject.emtreeAnalgesic agenten_US
dc.subject.emtreeAntidiabetic agenten_US
dc.subject.emtreeChlorogenic aciden_US
dc.subject.emtreePlant extracten_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAntidiabetic activityen_US
dc.subject.emtreeAntinociceptionen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeGlucose blood levelen_US
dc.subject.emtreeHyperalgesiaen_US
dc.subject.emtreeHyperglycemiaen_US
dc.subject.emtreeLong term careen_US
dc.subject.emtreeNeuropathic painen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSingle drug doseen_US
dc.subject.emtreeStreptozotocin-induced diabetic neuropathyen_US
dc.subject.emtreeTreatment durationen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeComplicationen_US
dc.subject.emtreeDiabetic neuropathiesen_US
dc.subject.emtreeExperimental diabetes mellitusen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePhytotherapyen_US
dc.subject.emtreeWistar raten_US
dc.subject.meshAnalgesicsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChlorogenic aciden_US
dc.subject.meshDiabetes mellitus, experimentalen_US
dc.subject.meshDiabetic neuropathiesen_US
dc.subject.meshHyperglycemiaen_US
dc.subject.meshHypoglycemic agentsen_US
dc.subject.meshMaleen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant extractsen_US
dc.subject.meshRats, wistaren_US
dc.subject.scopusAntioxidant; Carlina Oxide; Loniceraen_US
dc.subject.wosChemistry, medicinalen_US
dc.subject.wosFood science & technologyen_US
dc.subject.wosNutrition & dieteticsen_US
dc.titleAntinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathyen_US
dc.typeArticle
dc.wos.quartileQ3 (Chemistry, medicinal)en_US
dc.wos.quartileQ2 (Food science & technology)en_US
dc.wos.quartileQ4 (Nutrition & dietetics)en_US

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