Histamine restores hemorrhage induced hypotension by activating cholinergic neurons in nucleus tractus solitarius
dc.contributor.buuauthor | Altınbaş, Burçin | |
dc.contributor.buuauthor | Güvenç, Gökçen | |
dc.contributor.buuauthor | Erkan, Leman G. | |
dc.contributor.buuauthor | İlhan, Tuncay | |
dc.contributor.buuauthor | Niaz, Nasir | |
dc.contributor.buuauthor | Yalçın, Murat | |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-5600-8162 | tr_TR |
dc.contributor.researcherid | AAG-6956-2021 | tr_TR |
dc.contributor.researcherid | AAH-8859-2021 | tr_TR |
dc.contributor.researcherid | AAR-6815-2021 | tr_TR |
dc.contributor.researcherid | AAC-4975-2022 | tr_TR |
dc.contributor.scopusid | 55356919300 | tr_TR |
dc.contributor.scopusid | 56529426800 | tr_TR |
dc.contributor.scopusid | 56529371200 | tr_TR |
dc.contributor.scopusid | 16549312600 | tr_TR |
dc.contributor.scopusid | 57060367600 | tr_TR |
dc.contributor.scopusid | 57192959734 | tr_TR |
dc.date.accessioned | 2023-04-06T06:09:54Z | |
dc.date.available | 2023-04-06T06:09:54Z | |
dc.date.issued | 2016-06-30 | |
dc.description.abstract | The purpose of the current study is to investigate the functional connections between the central histaminergic and cholinergic systems at NTS level in hypotensive condition. Experiments were carried out in male Wistar Albino rats. The hypotension was achieved by withdrawing a total volume of 1.5 ml blood/100 g bodyweight over a period of 10 min. A microdialysis study was performed in NTS area to measure extracellular ACh and Ch levels. The hemorrhage produced a severe and long-lasting decrease in mean arterial blood pressure (MAP) and increase in extracellular ACh and Ch levels in NTS. Administration of histamine intracerebroventricularly (i.c.v.) or into the NTS reversed the hemorrhagic hypotension by increasing MAP and heart rate. I.c.v. injection of histamine also caused the additional increase in extracellular ACh and Ch levels. Moreover, central histamine injection augmented intracytoplasmic AChE immunoreactivity in NTS. These changes were completely blocked by histaminergic H1 receptor antagonist chlorpheniramine, but histaminergic H2 receptor blocker ranitidine and histaminergic H3/H4 receptor antagonist thioperamide failed to produce these effects. In conclusion, these findings are interpreted that brain histaminergic H1 receptor activation by central histamine injection may promote cholinergic stimulation in the NTS and subsequently reverses the hypotension. | en_US |
dc.identifier.citation | Altınbaş, B. vd. (2016). "Histamine restores hemorrhage induced hypotension by activating cholinergic neurons in nucleus tractus solitarius". Brain Research, 1649(Part A), 132-140. | en_US |
dc.identifier.endpage | 140 | tr_TR |
dc.identifier.issn | 0006-8993 | |
dc.identifier.issn | 1872-6240 | |
dc.identifier.issue | Part A | en_US |
dc.identifier.pubmed | 27373980 | tr_TR |
dc.identifier.scopus | 2-s2.0-84988311336 | tr_TR |
dc.identifier.startpage | 132 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.brainres.2016.06.047 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0006899316304723 | |
dc.identifier.uri | http://hdl.handle.net/11452/32207 | |
dc.identifier.volume | 1649 | tr_TR |
dc.identifier.wos | 000386408900014 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.bap | BAP-UAP(V)-2010/08 | tr_TR |
dc.relation.journal | Brain Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Neurosciences & neurology | en_US |
dc.subject | Histamine | en_US |
dc.subject | Nucleus tractus solitarius | en_US |
dc.subject | Central cholinergic system | en_US |
dc.subject | Cardiovascular system | en_US |
dc.subject | Hemorrhagic hypotension | en_US |
dc.subject | Endogenous central histamine | en_US |
dc.subject | Modulate acetylcholine-release | en_US |
dc.subject | Dual-probe microdialysis | en_US |
dc.subject | Freely moving rat | en_US |
dc.subject | Induced reversal | en_US |
dc.subject | Cardiovascular regulation | en_US |
dc.subject | Thromboxane A(2) | en_US |
dc.subject | Arachidonic-acid | en_US |
dc.subject | Injected melittin | en_US |
dc.subject | Ventral striatum | en_US |
dc.subject.emtree | Acetylcholinesterase | en_US |
dc.subject.emtree | Chlorpheniramine | en_US |
dc.subject.emtree | Cholinesterase | en_US |
dc.subject.emtree | Histamine | en_US |
dc.subject.emtree | Histamine H1 receptor | en_US |
dc.subject.emtree | Ranitidine | en_US |
dc.subject.emtree | Sodium chloride | en_US |
dc.subject.emtree | Thioperamide | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Animal cell | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Cardiovascular effect | en_US |
dc.subject.emtree | Cholinergic nerve cell | en_US |
dc.subject.emtree | Cholinergic stimulation | en_US |
dc.subject.emtree | Cholinergic system | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Drug efficacy | en_US |
dc.subject.emtree | Extracellular matrix | en_US |
dc.subject.emtree | Functional connectivity | en_US |
dc.subject.emtree | Heart rate | en_US |
dc.subject.emtree | Hemodynamics | en_US |
dc.subject.emtree | Hemorrhagic hypotension | en_US |
dc.subject.emtree | Hypotension | en_US |
dc.subject.emtree | Immunohistochemistry | en_US |
dc.subject.emtree | Immunoreactivity | en_US |
dc.subject.emtree | Injection | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Mean arterial pressure | en_US |
dc.subject.emtree | Microdialysis | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Solitary tract nucleus | en_US |
dc.subject.scopus | Histamine H4 Receptors; Thioperamide; Intracerebroventricular Drug Administration | en_US |
dc.subject.wos | Neurosciences | en_US |
dc.title | Histamine restores hemorrhage induced hypotension by activating cholinergic neurons in nucleus tractus solitarius | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: