Pharmacologic overview of chlorogenic acid and its metabolites in chronic pain and inflammation

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dc.contributor.authorMeade, Julie
dc.contributor.authorGül, Zülfiye
dc.contributor.authorBağdaş, Deniz
dc.contributor.buuauthorCam, Betül
dc.contributor.buuauthorCinkılıç, Nilüfer
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.departmentBursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3595-6286tr_TR
dc.contributor.researcheridAAH-5296-2021tr_TR
dc.contributor.researcheridCGO-3719-2022tr_TR
dc.contributor.researcheridDVX-8040-2022tr_TR
dc.contributor.scopusid56427863700tr_TR
dc.contributor.scopusid26533892300tr_TR
dc.contributor.scopusid55664349700tr_TR
dc.date.accessioned2022-12-19T12:11:21Z
dc.date.available2022-12-19T12:11:21Z
dc.date.issued2020
dc.description.abstractBackground: Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks. Objective: This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed. Materials and Methods: An electronic literature search was conducted by authors up to October 2019. Original articles were selected. Results: CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models. Conclusion: The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults.en_US
dc.identifier.citationBağdaş, D. vd. (2020). "Pharmacologic overview of chlorogenic acid and its metabolites in chronic pain and inflammation". Current Neuropharmacology, 18(3), 216-228.en_US
dc.identifier.endpage228tr_TR
dc.identifier.issn1570-159X
dc.identifier.issn1875-6190
dc.identifier.issue3tr_TR
dc.identifier.pubmed31631820tr_TR
dc.identifier.scopus2-s2.0-85079435812tr_TR
dc.identifier.startpage216tr_TR
dc.identifier.urihttps://doi.org/10.2174/1570159X17666191021111809
dc.identifier.urihttp://www.eurekaselect.com/article/101699
dc.identifier.urihttp://hdl.handle.net/11452/29959
dc.identifier.volume18tr_TR
dc.identifier.wos000514651000004tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherBentham Scienceen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalCurrent Neuropharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChlorogenicen_US
dc.subjectAciden_US
dc.subjectInflammationen_US
dc.subjectPainen_US
dc.subjectInflammatoryen_US
dc.subjectNeuropathicen_US
dc.subjectAntihyperalgesicen_US
dc.subjectAntiallodynicen_US
dc.subjectNF-Kappa Ben_US
dc.subjectGated potassium channelsen_US
dc.subjectGaba receptor agonistsen_US
dc.subjectNitric-oxide synthaseen_US
dc.subjectIncuded liver-injurytr_TR
dc.subjectOxygen species rosen_US
dc.subjectHypericum-perforatumen_US
dc.subjectCaffeic aciden_US
dc.subjectNeuropathic painen_US
dc.subjectIn-vitroen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.emtreeAntioxidanten_US
dc.subject.emtreeBidens pilosa extracten_US
dc.subject.emtreeCaffeic acidtr_TR
dc.subject.emtreeCheilanthes farinose extracten_US
dc.subject.emtreeChlorogenic aciden_US
dc.subject.emtreeChlorogenic acid derivativeen_US
dc.subject.emtreeCnidium officinale extracten_US
dc.subject.emtreeDrug metaboliteen_US
dc.subject.emtreeErycibe obtusifolia extracten_US
dc.subject.emtreeFerulic aciden_US
dc.subject.emtreeHypericum perforatum extracten_US
dc.subject.emtreeIon channelen_US
dc.subject.emtreeMansoa alliacea extracten_US
dc.subject.emtreePlant extracten_US
dc.subject.emtreePorana sinensis extracten_US
dc.subject.emtreeRosae multiflorae extracten_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeUrtica circularis extracten_US
dc.subject.emtreeAnalgesic agenten_US
dc.subject.emtreeAntiinflammatory agenten_US
dc.subject.emtreeChlorogenic aciden_US
dc.subject.emtreePlant extracten_US
dc.subject.emtreeAntiinflammatory activityen_US
dc.subject.emtreeAntinociceptionen_US
dc.subject.emtreeArthritisen_US
dc.subject.emtreeChronic painen_US
dc.subject.emtreeConsensusen_US
dc.subject.emtreeDegenerative diseaseen_US
dc.subject.emtreeDisease modelen_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeEthnopharmacologyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeIn vivo studyen_US
dc.subject.emtreeInflammationen_US
dc.subject.emtreeInflammatory painen_US
dc.subject.emtreeNeuropathic painen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePainen_US
dc.subject.emtreeReviewen_US
dc.subject.emtreeRheumatoid arthritisen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeChronic painen_US
dc.subject.emtreeComplicationen_US
dc.subject.emtreeEncephalitisen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeSepsisen_US
dc.subject.meshAnalgesicsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-inflammatory agentsen_US
dc.subject.meshChlorogenic aciden_US
dc.subject.meshChronic painen_US
dc.subject.meshDisease modelsen_US
dc.subject.meshAnimalen_US
dc.subject.meshEncephalitisen_US
dc.subject.meshHumansen_US
dc.subject.meshPlant extractsen_US
dc.subject.meshSepsisen_US
dc.subject.scopusAntioxidant; Carlina Oxide; Loniceraen_US
dc.subject.wosNeurosciencesen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titlePharmacologic overview of chlorogenic acid and its metabolites in chronic pain and inflammationen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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