Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators
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Date
2010-06-01
Journal Title
Journal ISSN
Volume Title
Publisher
Pergamon-Elsevier Science
Abstract
Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor.
Description
Keywords
Thyroxine, Esterification, Silylation, UV-vis, Angiogenesis, Nanopharmaceutical technology, Extracelluler segment, Crystal-structure, Thyhroid-hormone, Force-field, Proteins, Pharmacology & pharmacy, Chemistry
Citation
Bridoux, A. vd. (2010). "Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators". Bioorganic and Medicinal Chemistry Letters, 20(11), 3394-3398.