A comparison of three fibrinolytic agents in prevention of intra-abdominal adhesions

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dc.contributor.buuauthorTopal, Ersun
dc.contributor.buuauthorÖztürk, Ersin
dc.contributor.buuauthorŞen, Gürol
dc.contributor.buuauthorYerci, Ömer
dc.contributor.buuauthorYılmazlar, Tuncay
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid16069863000tr_TR
dc.contributor.scopusid35070171400tr_TR
dc.contributor.scopusid23013375200tr_TR
dc.contributor.scopusid6603810549tr_TR
dc.contributor.scopusid6701800362tr_TR
dc.date.accessioned2021-12-30T11:13:04Z
dc.date.available2021-12-30T11:13:04Z
dc.date.issued2010-02
dc.description.abstractPurpose : Three different drugs affecting the coagulation process at various stages were studied for their effectiveness in preventing intra-peritoneal adhesion formation in rats. Material and Methods: Forty female Wistar-Albino rats divided into four groups based on the drugs administered during the experimental laparotomy and caecal abrasion : the control group - no drug administered, the intra-peritoneal tissue plasminogen activator (TPA) group, the subcutaneous fondaparinux sodium (FS) group and the intra-peritoneal activated drotrecogin alfa (ADA) group. After two weeks, intra-peritoneal adhesions were macroscopically and micro-scopically scored. Results : The macroscopic scores of the three groups were similar but all lower than the control group (p = 0.002). Inflammation (p = 0.023) and fibrosis (p = 0.019) scores were lower in just the ADA group when compared to the control group. Conclusions : All three agents were effective in preventing adhesions when compared to the control group. Nevertheless, ADA seemed the most effective except when considering clinical applicability, in which case FS seemed to offer the greatest advantage.en_US
dc.identifier.citationTopal, E. vd. (2010). "A comparison of three fibrinolytic agents in prevention of intra-abdominal adhesions". Acta Chirurgica Belgica, 110(1), 71-75.en_US
dc.identifier.endpage75tr_TR
dc.identifier.issn0001-5458
dc.identifier.issue1tr_TR
dc.identifier.pubmed20306914tr_TR
dc.identifier.scopus2-s2.0-77949357377tr_TR
dc.identifier.startpage71tr_TR
dc.identifier.urihttps://doi.org/10.1080/00015458.2010.11680569
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/20306914/
dc.identifier.urihttp://hdl.handle.net/11452/23764
dc.identifier.volume110tr_TR
dc.identifier.wos000275654000017tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalActa Chirurgica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTissue plasminogen activatoren_US
dc.subjectFondaparinux sodiumen_US
dc.subjectAdhesionsen_US
dc.subjectPeritoneumen_US
dc.subjectMolecular-weight heparinen_US
dc.subjectPlasminogen-activatoren_US
dc.subjectSurgeryen_US
dc.subjectObstructionen_US
dc.subjectTraumaen_US
dc.subjectSurgeryen_US
dc.subject.scopusMeglumine Diatrizoate; Tissue Adhesions; Icodextrinen_US
dc.subject.wosSurgeryen_US
dc.titleA comparison of three fibrinolytic agents in prevention of intra-abdominal adhesionsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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