Frequency of recombinant and nonrecombinant products of pericentric inversion of chromosome 1 in sperm nuclei of carrier: By FISH technique

dc.contributor.authorAcar, Hasan
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorKimya, Yalçın
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.scopusid6602802424tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid6603919968tr_TR
dc.date.accessioned2022-04-21T06:53:40Z
dc.date.available2022-04-21T06:53:40Z
dc.date.issued2003-09
dc.description.abstractMeiotic segregation products of carriers with pericentric inversion are very important for assessing the risk of unbalanced forms and appropriate genetic counseling. We investigated the incidence of recombinant and nonrecombinant products of chromosome 1 with pericentric inversion, in the sperm nuclei of the carrier by using triple color fluorescence in situ hybridization (FISH). The centromere specific and telomere specific probes for chromosome 1 were used. In the segregation analysis, 1,636 sperm nuclei were analyzed; 82.5% of the sperms were including normal or inverted chromosome 1, and the dup(p)/del(q) and del(p)/dup(q) recombinant products in sperm nuclei of our carrier were 8.7 and 7.3%, respectively. The number of recombinant products may be dependent on the formation of an inversion loop, which the number of the formation of chiasmata results in the different number of normal/balanced and recombinant products. The use of FISH, using different probe combination, in sperm nuclei has proved to be an accurate approach to determine the meiotic segregation patterns and could help to better establish a reproductive prognosis and genetic counseling.en_US
dc.identifier.citationYakut, T. vd. (2003). “Frequency of recombinant and nonrecombinant products of pericentric inversion of chromosome 1 in sperm nuclei of carrier: By FISH technique”. Molecular Reproduction and Development, 66(1), 67-71.en_US
dc.identifier.endpage71tr_TR
dc.identifier.issn1040-452X
dc.identifier.issue1tr_TR
dc.identifier.pubmed12874801tr_TR
dc.identifier.scopus2-s2.0-0042267426tr_TR
dc.identifier.startpage67tr_TR
dc.identifier.urihttps://doi.org/10.1002/mrd.10325
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/mrd.10325
dc.identifier.urihttp://hdl.handle.net/11452/25931
dc.identifier.volume66tr_TR
dc.identifier.wos000184529700010tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalMolecular Reproduction and Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemistry and molecular biologyen_US
dc.subjectCell biologyen_US
dc.subjectDevelopmental biologyen_US
dc.subjectReproductive biologyen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCell nucleusen_US
dc.subject.emtreeCentromereen_US
dc.subject.emtreeChromosome 1en_US
dc.subject.emtreeChromosome chiasmen_US
dc.subject.emtreeChromosome segregationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFluorescence in situ hybridizationen_US
dc.subject.emtreeGenetic counselingen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMeiosisen_US
dc.subject.emtreeNormal humanen_US
dc.subject.emtreePericentric chromosome inversionen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeSpermen_US
dc.subject.emtreeTelomereen_US
dc.subject.meshCell nucleusen_US
dc.subject.meshChromosome aberrationsen_US
dc.subject.meshChromosomes, human, pair 1en_US
dc.subject.meshHumansen_US
dc.subject.meshIn situ hybridization, fluorescenceen_US
dc.subject.meshMaleen_US
dc.subject.meshSpermatozoaen_US
dc.subject.scopusRobertsonian Chromosome Translocation; Balanced; Chromosome Aberrationsen_US
dc.subject.wosBiochemistry and molecular biologyen_US
dc.subject.wosCell biologyen_US
dc.subject.wosDevelopmental biologyen_US
dc.subject.wosReproductive biologyen_US
dc.titleFrequency of recombinant and nonrecombinant products of pericentric inversion of chromosome 1 in sperm nuclei of carrier: By FISH techniqueen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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