Enzymatic generation of highly anticoagulant bovine intestinal heparin

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dc.contributor.authorFu, Li
dc.contributor.authorLi, Kevin
dc.contributor.authorHirakane, Makoto
dc.contributor.authorLin, Lei
dc.contributor.authorGrover, Navdeep
dc.contributor.authorDatta, Payel
dc.contributor.authorYu, Yanlei
dc.contributor.authorZhao, Jing
dc.contributor.authorZhang, Fuming
dc.contributor.authorMousa, Shaker A.
dc.contributor.authorDordick, Jonathan S.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.scopusid57192959734tr_TR
dc.date.accessioned2022-11-03T12:10:59Z
dc.date.available2022-11-03T12:10:59Z
dc.date.issued2017-10-26
dc.description.abstractUnlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1,-3, and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA - HL096972 - HL62244 - HL094463 - GM38060tr_TR
dc.identifier.citationFu, L. vd. (2017). ''Enzymatic generation of highly anticoagulant bovine intestinal heparin''. Journal of Medicinal Chemistry, 60(20), 8673-8679.en_US
dc.identifier.endpage8679tr_TR
dc.identifier.issn0022-2623
dc.identifier.issn1520-4804
dc.identifier.issue20tr_TR
dc.identifier.pubmed28972371tr_TR
dc.identifier.scopus2-s2.0-85032449266tr_TR
dc.identifier.startpage8673tr_TR
dc.identifier.urihttps://doi.org/10.1021/acs.jmedchem.7b01269
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01269?cookieSet=1
dc.identifier.urihttp://hdl.handle.net/11452/29361
dc.identifier.volume60tr_TR
dc.identifier.wos000414114300030
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAmer Chemicalen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalJournal of Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectMolecular-weight heparinsen_US
dc.subjectChemoenzymatic synthesisen_US
dc.subjectInduced thrombocytopeniaen_US
dc.subjectPharmaceutical heparinsen_US
dc.subjectChondroitin sulfateen_US
dc.subjectPorcineen_US
dc.subjectBindingen_US
dc.subjectTissuesen_US
dc.subjectDrugsen_US
dc.subject.emtree3 o sulfotransferaseen_US
dc.subject.emtree6 o sulfotransferaseen_US
dc.subject.emtreeAnticoagulant agenten_US
dc.subject.emtreeAntithrombin IIIen_US
dc.subject.emtreeBovine intestinal heparinen_US
dc.subject.emtreeHeparinen_US
dc.subject.emtreeSulfotransferaseen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAnticoagulant agenten_US
dc.subject.emtreeEnzymeen_US
dc.subject.emtreeHeparinen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnticoagulationen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBinding affinityen_US
dc.subject.emtreeBinding siteen_US
dc.subject.emtreeBioengineeringen_US
dc.subject.emtreeChemical compositionen_US
dc.subject.emtreeEnzyme modificationen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeProtein bindingen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBiosynthesisen_US
dc.subject.emtreeBovineen_US
dc.subject.emtreeCarbohydrate analysisen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeIntestineen_US
dc.subject.emtreeLeporidaeen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeNuclear magnetic resonance spectroscopyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnticoagulantsen_US
dc.subject.meshCarbohydrate sequenceen_US
dc.subject.meshCattleen_US
dc.subject.meshEnzymesen_US
dc.subject.meshHeparinen_US
dc.subject.meshIntestinesen_US
dc.subject.meshMagnetic resonance spectroscopyen_US
dc.subject.meshRabbitsen_US
dc.subject.scopusHeparan Sulfate; Heparosan; Glycosaminoglycansen_US
dc.subject.wosChemistry, medicinalen_US
dc.titleEnzymatic generation of highly anticoagulant bovine intestinal heparinen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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