Protective effects of Nigella sativa Oil in hyperoxia-induced lung injury

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dc.contributor.authorTayman, Cüneyt
dc.contributor.authorÇekmez, Ferhat
dc.contributor.authorCanpolat, Fuat Emre
dc.contributor.authorÇetinkaya, Merih
dc.contributor.authorTonbul, Alparslan
dc.contributor.authorUysal, Sema
dc.contributor.authorTunç, Turan
dc.contributor.authorSarıcı, Serdar Ümit
dc.contributor.buuauthorKafa, İlker Mustafa
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-7125-2021tr_TR
dc.contributor.scopusid8450193200tr_TR
dc.date.accessioned2022-10-03T10:14:27Z
dc.date.available2022-10-03T10:14:27Z
dc.date.issued2013-01
dc.description.abstractBackground: Oxygen-induced lung injury is believed to lead to the development of bronchopulmonary dysplasia in premature infants. We have evaluated the beneficial effects of Nigella sativa oil (NSO) on rats with hyperoxia-induced lung injury. Methods: Thirty newborn Sprague-Dawley rats were randomly divided into 3 groups as hyperoxia (95% O-2), hyperoxia + NSO and control (21% O-2). Pups in the hyperoxia + NSO group were administered intraperitoneal NSO at a dose of 4 ml/kg daily during the study period. Histopathologic, immunochemical, and biochemical evaluations (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], malonaldehyde [MDA] and myeloperoxidase [MPO]) were performed. Results: In the histopathologic and immunochemical evaluation, severity of lung damage was significantly lower in the hyperoxia + NOS group (P<.05). Tissue GSH-Px and SOD levels were significantly preserved, and MDA, MPO levels were significantly lower in the hyperoxia + NSO group (P<.05). Conclusion: NSO significantly reduced the severity of lung damage due to hyperoxia.en_US
dc.identifier.citationTayman, C. vd. (2013). "Protective effects of Nigella sativa Oil in hyperoxia-induced lung injury". Archivos de Bronconeumologia, 49(1), 15-21.en_US
dc.identifier.endpage21tr_TR
dc.identifier.issn0300-2896
dc.identifier.issn1579-2129
dc.identifier.issue1tr_TR
dc.identifier.pubmed22592006tr_TR
dc.identifier.scopus2-s2.0-84871720352tr_TR
dc.identifier.startpage15tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.arbres.2012.03.013
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/22592006/
dc.identifier.urihttp://hdl.handle.net/11452/28926
dc.identifier.volume49tr_TR
dc.identifier.wos000313859300003
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalArchivos de Bronconeumologiafre
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRespiratory systemen_US
dc.subjectBronchopulmonary dysplasiaen_US
dc.subjectOxygen-induced lung injuryen_US
dc.subjectPreterm infantsen_US
dc.subjectNigella sativa oilen_US
dc.subjectProtectionen_US
dc.subjectRaten_US
dc.subjectOxygenen_US
dc.subjectAntioxidantsen_US
dc.subjectInflammationen_US
dc.subjectElastaseen_US
dc.subjectDamageen_US
dc.subjectRatsen_US
dc.subject.emtreeGlutathione peroxidaseen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeMyeloperoxidaseen_US
dc.subject.emtreeNigella sativa oilen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeVegetable oilen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBiochemical compositionen_US
dc.subject.emtreeBlack cuminen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeHyperoxiaen_US
dc.subject.emtreeImmunochemistryen_US
dc.subject.emtreeLung injuryen_US
dc.subject.emtreeNewbornen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.scopusThymoquinone; Nigella Sativa; Antioxidanten_US
dc.subject.wosRespiratory systemen_US
dc.titleProtective effects of Nigella sativa Oil in hyperoxia-induced lung injuryen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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