The effect of L-glutamine on mucosal healing in experimental colitis is superior to short-chain fatty acids
dc.contributor.author | Ceylan, Alper | |
dc.contributor.author | Kara, Nurten | |
dc.contributor.author | Güven, Hakan | |
dc.contributor.author | Yıldız, Levent | |
dc.contributor.buuauthor | Kaya, Ekrem | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-9562-4195 | tr_TR |
dc.contributor.researcherid | AAG-7319-2021 | tr_TR |
dc.contributor.scopusid | 7004568109 | tr_TR |
dc.date.accessioned | 2024-03-14T07:54:08Z | |
dc.date.available | 2024-03-14T07:54:08Z | |
dc.date.issued | 2007-06 | |
dc.description.abstract | Background/aims: The effects of short-chain fatty acids and glutamine on diseased colonic mucosa, such as in inflammatory bowel disease, are not well described. The aim of this study was to investigate the role of L-glutamine and short-chain fatty acids, both via enema and oral administration, on mucosal healing in experimental colitis. Methods: Colitis was induced with trinitrobenzenesulphonic acid in ethanol enema in rats. Saline enema (Colitis group, n: 12), L-glutamine enema (n: 12), short-chain fatty acids enema (n: 12), oral L-glutamine (n:11) and oral short-chain fatty acids (n. 11) were applied twice daily for 10 days after induction of colitis. The sham group (n: 12) received only saline enema. Rats were sacrificed at the tenth day. Crypt depth and DNA content were measured in colonic mucosa. Results: Crypt depth was significantly greater in both glutamine groups and short-chain fatty acids enema group than in sham and colitis groups (p<0.05). The mucosal DNA contents of the colitis and glutamine enema groups were significantly greater than both short-chain fatty acids groups (p<0.05). DNA content in the oral glutamine group was significantly greater than in the short-chain fatty acids enema group (p<0.05). Conclusions: L-glutamine enema can accelerate mucosal healing and regeneration in experimentally induced colitis in rats. When compared to glutamine in this study, short-chain fatty acids showed no beneficial effect on colitis. | en_US |
dc.identifier.citation | Kaya, L. vd. (2007). "The effect of L-glutamine on mucosal healing in experimental colitis is superior to short-chain fatty acids". Turkish Journal of Gastroenterology, 18(2), 89-94. | en_US |
dc.identifier.endpage | 94 | tr_TR |
dc.identifier.issn | 1300-4948 | |
dc.identifier.issue | 2 | tr_TR |
dc.identifier.pubmed | 17602355 | tr_TR |
dc.identifier.scopus | 2-s2.0-43549126223 | tr_TR |
dc.identifier.startpage | 88 | tr_TR |
dc.identifier.uri | https://hdl.handle.net/11452/40391 | en_US |
dc.identifier.volume | 18 | tr_TR |
dc.identifier.wos | 000254609800005 | tr_TR |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Aves | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | Turkish Journal of Gastroenterology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Experimental colitis | en_US |
dc.subject | Glutamine | en_US |
dc.subject | Short-chain fatty acid | en_US |
dc.subject | Gastroenterology & hepatology | en_US |
dc.subject | Absorption | en_US |
dc.subject | Enemas | en_US |
dc.subject | Rat | en_US |
dc.subject | Distal colon | en_US |
dc.subject | Rectal irrigation | en_US |
dc.subject | Experimental-model | en_US |
dc.subject | Cell proliferation | en_US |
dc.subject | Butyrate metabolism | en_US |
dc.subject | Colonic-mucosa | en_US |
dc.subject | Quiescent ulcerative-colitis | en_US |
dc.subject.emtree | Alcohol | en_US |
dc.subject.emtree | Butyric acid | en_US |
dc.subject.emtree | Dna | en_US |
dc.subject.emtree | Enema | en_US |
dc.subject.emtree | Glutamine | en_US |
dc.subject.emtree | Short chain fatty acid | en_US |
dc.subject.emtree | Sodium chloride | en_US |
dc.subject.emtree | Trinitrobenzenesulfonic acid animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Colitis | en_US |
dc.subject.emtree | Colon mucosa | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Diarrhea | en_US |
dc.subject.emtree | Dna content | en_US |
dc.subject.emtree | Experimental study | en_US |
dc.subject.emtree | Histopathology | en_US |
dc.subject.emtree | Inflammation | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Weight change | en_US |
dc.subject.emtree | Wound healing | en_US |
dc.subject.mesh | Administration, oral | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Colitis | en_US |
dc.subject.mesh | Disease models, animal | en_US |
dc.subject.mesh | Dna | en_US |
dc.subject.mesh | Enema | en_US |
dc.subject.mesh | Glutamine | en_US |
dc.subject.mesh | Intestinal mucosa | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, wistar | en_US |
dc.subject.mesh | Regeneration | en_US |
dc.subject.mesh | Wound healing | en_US |
dc.subject.scopus | Volatile Fatty Acid; Butyric Acid; Intestine Flora | en_US |
dc.subject.wos | Gastroenterology & hepatology | en_US |
dc.title | The effect of L-glutamine on mucosal healing in experimental colitis is superior to short-chain fatty acids | en_US |
dc.type | Article | en_US |
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