Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease
dc.contributor.buuauthor | Sarıcaoğlu, Hayriye | |
dc.contributor.buuauthor | Yılmaz, Mediha | |
dc.contributor.buuauthor | Karkucak, Mutlu | |
dc.contributor.buuauthor | Öztürk, Hülya Z.Y. | |
dc.contributor.buuauthor | Yakut, Tahsin | |
dc.contributor.buuauthor | Gülten, Tuna | |
dc.contributor.buuauthor | Bülbül, Emel Başkan | |
dc.contributor.buuauthor | Aydoğan, Kenan | |
dc.contributor.buuauthor | Dilek, Kamil | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-0144-3263 | tr_TR |
dc.contributor.researcherid | AAH-1388-2021 | tr_TR |
dc.contributor.scopusid | 6603722836 | tr_TR |
dc.contributor.scopusid | 35148700000 | tr_TR |
dc.contributor.scopusid | 35388323500 | tr_TR |
dc.contributor.scopusid | 57197115377 | tr_TR |
dc.contributor.scopusid | 6602802424 | tr_TR |
dc.contributor.scopusid | 6505944216 | tr_TR |
dc.contributor.scopusid | 6602518817 | tr_TR |
dc.contributor.scopusid | 9739755800 | tr_TR |
dc.contributor.scopusid | 56005080200 | tr_TR |
dc.date.accessioned | 2021-12-29T12:03:21Z | |
dc.date.available | 2021-12-29T12:03:21Z | |
dc.date.issued | 2011 | |
dc.description.abstract | Colchicine is commonly used in the treatment of Behcet's disease. However, some patients are unresponsive to colchicine treatment. Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) transports colchicine out of cells. We investigated a possible association of C3435T polymorphism of the ABCB1 (MDR1) gene with colchicine response in patients with Behcet's disease. We randomly selected 97 patients with Behcet's disease, examined ABCB1 (MDR1) gene C3435T polymorphisms, and evaluated patient responses to colchicine. Forty-three patients were colchicine responsive, while the remaining 54 patients were unresponsive. No significant difference was found between genotypic and allelic frequencies of the ABCB1 C3435T polymorphisms in patients with Behcet's disease and healthy volunteers. Also, there was no significant difference among responsive and nonresponsive patients. We concluded that ABCB1 C3435T polymorphism is not associated with a colchicine response in patients with Behcet's disease. | en_US |
dc.identifier.citation | Sarıcaoğlu, H. vd. (2011). "Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease". Genetics and Molecular Research, 10(1), 1-6. | en_US |
dc.identifier.endpage | 6 | tr_TR |
dc.identifier.issn | 1676-5680 | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 21218380 | tr_TR |
dc.identifier.scopus | 2-s2.0-79251515771 | tr_TR |
dc.identifier.startpage | 1 | tr_TR |
dc.identifier.uri | https://doi.org/10.4238/vol10-1gmr824 | |
dc.identifier.uri | http://www.funpecrp.com.br/gmr/year2011/vol10-1/pdf/gmr824.pdf | |
dc.identifier.uri | http://hdl.handle.net/11452/23737 | |
dc.identifier.volume | 10 | tr_TR |
dc.identifier.wos | 000286527300001 | tr_TR |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Funpec-Editora | en_US |
dc.relation.journal | Genetics and Molecular Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Biochemistry & molecular biology | en_US |
dc.subject | Genetics & heredity | en_US |
dc.subject | Behcet's disease | en_US |
dc.subject | Colchicine | en_US |
dc.subject | ABCB1 gene | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Familial mediterranean fever | en_US |
dc.subject | Multidrug-resistance gene | en_US |
dc.subject | P-glycoprotein | en_US |
dc.subject | Clinical-relevance | en_US |
dc.subject | Mdr1 | en_US |
dc.subject | Association | en_US |
dc.subject | Efficacy | en_US |
dc.subject.emtree | Colchicine | en_US |
dc.subject.emtree | Multidrug resistance protein 1 | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Behcet disease | en_US |
dc.subject.emtree | Diarrhea | en_US |
dc.subject.emtree | Drug withdrawal | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Gene frequency | en_US |
dc.subject.emtree | Genetic association | en_US |
dc.subject.emtree | Genetic polymorphism | en_US |
dc.subject.emtree | Genotype | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Leukopenia | en_US |
dc.subject.emtree | Liver dysfunction | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Randomized controlled trial | en_US |
dc.subject.emtree | Side effect | en_US |
dc.subject.emtree | Stomach disease | en_US |
dc.subject.emtree | Treatment response | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Behcet syndrome | en_US |
dc.subject.mesh | Case control studies | en_US |
dc.subject.mesh | Colchicine | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gene frequency | en_US |
dc.subject.mesh | Genotype | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | P-glycoprotein | en_US |
dc.subject.mesh | Polymorphism, single nucleotide | en_US |
dc.subject.scopus | MDR Gene; Multidrug Resistance Protein 1; Restriction Fragment Length Polymorphisms | en_US |
dc.subject.wos | Biochemistry & molecular biology | en_US |
dc.subject.wos | Genetics & heredity | en_US |
dc.title | Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease | en_US |
dc.type | Article |