Parmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis-like cell death and DNA damage in cancer cells

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dc.contributor.buuauthorArı, Ferda
dc.contributor.buuauthorAztopal, Nazlıhan
dc.contributor.buuauthorOran, Seyhan
dc.contributor.buuauthorBozdemir, Şefika
dc.contributor.buuauthorÇelikler, Serap
dc.contributor.buuauthorÖztürk, Şule
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-6729-7908tr_TR
dc.contributor.orcid0000-0001-8196-2065tr_TR
dc.contributor.orcid0000-0002-4177-3478tr_TR
dc.contributor.orcid0000-0003-3118-8061tr_TR
dc.contributor.researcheridAAG-7012-2021tr_TR
dc.contributor.researcheridAAD-7322-2019tr_TR
dc.contributor.researcheridAAH-5039-2021tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.researcheridAAH-2767-2021tr_TR
dc.contributor.researcheridL-6687-2018tr_TR
dc.contributor.scopusid24376085300tr_TR
dc.contributor.scopusid55853882900tr_TR
dc.contributor.scopusid14067648200tr_TR
dc.contributor.scopusid57506388900tr_TR
dc.contributor.scopusid8234554800tr_TR
dc.contributor.scopusid7004555373tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.date.accessioned2022-09-05T06:46:53Z
dc.date.available2022-09-05T06:46:53Z
dc.date.issued2014-10
dc.description.abstractSuccessful cancer treatments still require more compounds to be isolated from natural sources. Thus, we have investigated anti-proliferative/apoptotic effects of methanolic extracts of lichen species Parmelia sulcata Taylor and Usnea filipendula Stirt on human lung cancer (A549, PC3), liver cancer (Hep3B) and rat glioma (C6) cells. Materials and methodsAnti-proliferative effects were monitored by MTT and adenosine triphosphate viability assays, while genotoxic activity was studied using the comet assay. Additionally, cell death mode and apoptosis assays (fluorescence staining, caspase-cleaved cytokeratin 18, caspase-3 activity and PARP cleavage) were performed. ResultsExtracts produced anti-population growth effects in a dose-dependent manner (1.56-100g/ml) by inducing apoptosis-like cell death. This resulted in the lines having the presence of pyknotic cell nuclei. In addition, significant increase in genetic damage in the cell lines was seen, indicating that DNA damage may have been responsible for apoptotic cell death. ConclusionIn this study, methanolic extracts of Parmelia sulcata and Usnea filipendula induced apoptosis-like cell death by causing DNA damage, to cancer cells.en_US
dc.identifier.citationArı, F. vd. (2014). "Parmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis-like cell death and DNA damage in cancer cells". Cell Proliferation, 47(5), 457-464.en_US
dc.identifier.endpage464tr_TR
dc.identifier.issn0960-7722
dc.identifier.issn1365-2184
dc.identifier.issue5tr_TR
dc.identifier.pubmed25081971tr_TR
dc.identifier.scopus2-s2.0-84908653918tr_TR
dc.identifier.startpage457tr_TR
dc.identifier.urihttps://doi.org/10.1111/cpr.12123
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/cpr.12123
dc.identifier.urihttp://hdl.handle.net/11452/28447
dc.identifier.volume47tr_TR
dc.identifier.wos000341982600009
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.bapUAP(F)-2011/42tr_TR
dc.relation.journalCell Proliferationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectLichenen_US
dc.subjectChemotherapyen_US
dc.subjectMetabolitesen_US
dc.subjectGrowthen_US
dc.subjectCell biologyen_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeCaspase 3en_US
dc.subject.emtreeCytokeratin 18en_US
dc.subject.emtreeMethanolen_US
dc.subject.emtreeNicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferaseen_US
dc.subject.emtreeParmelia sulcata extracten_US
dc.subject.emtreePlant extracten_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeUsnea filipendula extracten_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAntiproliferative activityen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeATPase activity assayen_US
dc.subject.emtreeCancer cellen_US
dc.subject.emtreeCancer cell lineen_US
dc.subject.emtreeCancer inhibitionen_US
dc.subject.emtreeCell deathen_US
dc.subject.emtreeCell nucleusen_US
dc.subject.emtreeCell viability assayen_US
dc.subject.emtreeComet assayen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDNA damageen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeFluorescenceen_US
dc.subject.emtreeGenotoxicityen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeMedicinal planten_US
dc.subject.emtreeMTT assayen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeParmelia sulcataen_US
dc.subject.emtreeProtein cleavageen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeUsneaen_US
dc.subject.emtreeUsnea filipendulaen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeAscomycetesen_US
dc.subject.emtreeBrain neoplasmsen_US
dc.subject.emtreeCell proliferationen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeEnzyme activationen_US
dc.subject.emtreeGliomaen_US
dc.subject.emtreeLiver neoplasmsen_US
dc.subject.emtreeLung neoplasmsen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeNeoplasmsen_US
dc.subject.emtreeTumor cell lineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshAscomycotaen_US
dc.subject.meshBrain neoplasmsen_US
dc.subject.meshCaspase 3en_US
dc.subject.meshCell line, tumoren_US
dc.subject.meshCell proliferationen_US
dc.subject.meshDNA damageen_US
dc.subject.meshEnzyme activationen_US
dc.subject.meshGliomaen_US
dc.subject.meshHumansen_US
dc.subject.meshKeratin-18en_US
dc.subject.meshLiver neoplasmsen_US
dc.subject.meshLung neoplasmsen_US
dc.subject.meshNeoplasmsen_US
dc.subject.meshPoly(ADP-ribose) polymerasesen_US
dc.subject.meshRatsen_US
dc.subject.meshUsneaen_US
dc.subject.scopusUsnic Acid; Extract; Lichen (Disease)en_US
dc.subject.wosCell biologyen_US
dc.titleParmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis-like cell death and DNA damage in cancer cellsen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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