Neurological and neurophysiological effects of oral isotretinoin: A prospective investigation using auditory and visual evoked potentials
dc.contributor.author | Karadogan, Serap Koran | |
dc.contributor.buuauthor | Aydoğan, Kenan | |
dc.contributor.buuauthor | Turan, Ömer Faruk | |
dc.contributor.buuauthor | Onart, Selçuk | |
dc.contributor.buuauthor | Yazıcı, Bülent | |
dc.contributor.buuauthor | Tokgöz, Necdet | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Baş ve Boyun Cerrahisi Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0001-8889-1933 | tr_TR |
dc.contributor.researcherid | AAH-6216-2021 | tr_TR |
dc.contributor.researcherid | AAA-5384-2020 | tr_TR |
dc.contributor.scopusid | 9739755800 | tr_TR |
dc.contributor.scopusid | 23037113500 | tr_TR |
dc.contributor.scopusid | 7801637934 | tr_TR |
dc.contributor.scopusid | 7005398015 | tr_TR |
dc.contributor.scopusid | 9738885800 | tr_TR |
dc.contributor.scopusid | 8286857800 | tr_TR |
dc.date.accessioned | 2024-04-02T10:49:35Z | |
dc.date.available | 2024-04-02T10:49:35Z | |
dc.date.issued | 2008 | |
dc.description.abstract | Over the last decade, accumulating evidence has indicated that retinoids may be capable of affecting the development, differentiation and function of nervous tissue. The purpose of the present study was to investigate whether oral isotretinoin can affect brainstem and cortical sensorial activities. We performed neurological and neurophysiological studies (brainstem auditory and visual evoked potentials) in 32 patients with various skin diseases receiving isotretinoin. A significant increase of the third (L,,,) and fifth peak latency (L-V) in left and right ear (p = 0.03, p = 0.02 for L-m, p = 0.03, p = 0.04 for L-V respectively), and a significant increase in the latency of wave one and interpeak latency (IPL) I-V in the left ear were found after isotretinoin administration, as compared to the pretreatment (p = 0.0036 and p = 0.02, respectively). No significant differences of other latencies, IPLs and the value of visual evoked potential P-100 implicit time were observed. However, a marked increase in latency P-100 wave was found in 6 patients after therapy. It seems reasonable to suggest that neurophysiological and neurological evaluation of audiological and Ocular nerve (or retinal) function may be added to the list of investigations that are performed in patients treated with oral isotretinoin. | en_US |
dc.identifier.citation | Aydoğan, K. vd. (2008). "Neurological and neurophysiological effects of oral isotretinoin: A prospective investigation using auditory and visual evoked potentials". European Journal of Dermatology, 18(6), 642-646. | en_US |
dc.identifier.endpage | 646 | tr_TR |
dc.identifier.issn | 1167-1122 | |
dc.identifier.issn | 1952-4013 | |
dc.identifier.issue | 6 | tr_TR |
dc.identifier.pubmed | 18955197 | tr_TR |
dc.identifier.scopus | 2-s2.0-57749196926 | tr_TR |
dc.identifier.startpage | 642 | tr_TR |
dc.identifier.uri | https://doi.org/10.1684/ejd.2008.0512 | en_US |
dc.identifier.uri | https://hdl.handle.net/11452/40912 | en_US |
dc.identifier.volume | 18 | tr_TR |
dc.identifier.wos | 000261725000005 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | John Libbey Eurotext | en_US |
dc.relation.journal | European Journal of Dermatology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Auditory and visual evoked potentials | en_US |
dc.subject | Isotretinoin | en_US |
dc.subject | Neurotoxicity | en_US |
dc.subject | Anormal retinal function | en_US |
dc.subject | Nervous-system | en_US |
dc.subject | Therapy | en_US |
dc.subject | Brain | en_US |
dc.subject | Acid | en_US |
dc.subject | Dermatology | en_US |
dc.subject.emtree | Artificial tear | en_US |
dc.subject.emtree | Emollient agent | en_US |
dc.subject.emtree | Isotretinoin | en_US |
dc.subject.emtree | Acne | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Audiometry | en_US |
dc.subject.emtree | Auditory system examination | en_US |
dc.subject.emtree | Blepharoconjunctivitis | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Clinical trial | en_US |
dc.subject.emtree | Color vision defect | en_US |
dc.subject.emtree | Conjunctivitis | en_US |
dc.subject.emtree | Controlled clinical trial | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Drug efficacy | en_US |
dc.subject.emtree | Drug mechanism | en_US |
dc.subject.emtree | Drug megadose | en_US |
dc.subject.emtree | Drug safety | en_US |
dc.subject.emtree | Dry eye | en_US |
dc.subject.emtree | Evoked auditory response | en_US |
dc.subject.emtree | Evoked brain stem response | en_US |
dc.subject.emtree | Evoked visual response | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Latent period | en_US |
dc.subject.emtree | Lichen planus | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Mucocutaneous candidiasis | en_US |
dc.subject.emtree | Neurologic examination | en_US |
dc.subject.emtree | Neurophysiology | en_US |
dc.subject.emtree | Rosacea | en_US |
dc.subject.emtree | Side effect | en_US |
dc.subject.emtree | Visual acuity | en_US |
dc.subject.emtree | Visual field defect | en_US |
dc.subject.emtree | Visual impairment | en_US |
dc.subject.mesh | Administration, oral | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Dermatologic agents | en_US |
dc.subject.mesh | Evoked Potentials, auditory | en_US |
dc.subject.mesh | Evoked Potentials, auditory, brain stem | en_US |
dc.subject.mesh | Evoked potentials, visual | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Isotretinoin | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Reaction time | en_US |
dc.subject.scopus | Isotretinoin; Acne Vulgaris; Retinoids | en_US |
dc.subject.wos | Dermatology | en_US |
dc.title | Neurological and neurophysiological effects of oral isotretinoin: A prospective investigation using auditory and visual evoked potentials | en_US |
dc.type | Article | en_US |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: