Effects of hypoxic preconditioning in antioxidant enzyme activities in hypoxic-ischemic brain damage in immature rats

dc.contributor.buuauthorAlkan, Tülin
dc.contributor.buuauthorGören, Bülent
dc.contributor.buuauthorVatansever, Ebru
dc.contributor.buuauthorSarandöl, Emre
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-6466-5042tr_TR
dc.contributor.orcid0000-0002-2593-7196tr_TR
dc.contributor.researcheridAAH-1792-2021tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.contributor.researcheridAAH-1718-2021tr_TR
dc.contributor.scopusid6601953747tr_TR
dc.contributor.scopusid6602543716tr_TR
dc.contributor.scopusid16070622700tr_TR
dc.contributor.scopusid55943324800tr_TR
dc.date.accessioned2022-02-16T12:54:22Z
dc.date.available2022-02-16T12:54:22Z
dc.date.issued2008-04
dc.description.abstractAim: HI (hypoxic-ischemic) brain injury is a major cause of neonatal mortality and longterm neurological morbidity. The aim of the present study was to investigate the effects of HPC (hypoxic preconditioning) on the oxidative-antioxidative status in the neonatal HI brain model. Material and Methods: Fifty five 7-day-old rats were placed into; Control, HPC, HPC+HI insult, and HI insult groups. HPC, The HPC+HI insult groups were subjected to hypoxia (37°C, 8%O2) and the control group to normoxia for 2.5 hrs. Twenty-four hours later, the rats in the HPC+HI insult and HI insult groups were exposed to cerebral HI produced by unilateral right common carotid artery (CCA) occlusion combined with 90 min hypoxia. Four hours after recovery, the malondialdehyde (MDA) level and the activities of superoxide dismutase (SOD), and glutathione peroxidase (GPx) were determined in the brain tissues of the rats. Results: The findings of the present study suggest increased lipid peroxidation and/or decreased antioxidant activity in the brain of the HI rats. Conclusion: The beneficial effects of HPC might not be related to the alterations in the antioxidative activity.en_US
dc.identifier.citationAlkan, T. vd. (2008). "Effects of hypoxic preconditioning in antioxidant enzyme activities in hypoxic-ischemic brain damage in immature rats". Turkish Neurosurgery, 18(2), 165-171.tr_TR
dc.identifier.endpage171tr_TR
dc.identifier.issn1019-5149
dc.identifier.issue2tr_TR
dc.identifier.pubmed18597231tr_TR
dc.identifier.scopus2-s2.0-58149107383tr_TR
dc.identifier.startpage165tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/24506
dc.identifier.volume18tr_TR
dc.identifier.wos000257945100008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTürk Nöroşurji Derneğitr_TR
dc.relation.journalTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant enzymesen_US
dc.subjectHypoxic ischemic brain damageen_US
dc.subjectLipid peroxidationen_US
dc.subjectNeuroprotectionen_US
dc.subjectPreconditioningen_US
dc.subjectNeurosciences & Neurologyen_US
dc.subjectSurgeryen_US
dc.subjectNeonatal-raten_US
dc.subjectLipid-peroxidationen_US
dc.subjectToleranceen_US
dc.subjectNeuroprotectionen_US
dc.subjectProtectionen_US
dc.subjectMechanismen_US
dc.subjectInjuryen_US
dc.subject.emtreeAntioxidanten_US
dc.subject.emtreeGlutathione peroxidaseen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeAgeen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBrainen_US
dc.subject.emtreeBrain ischemiaen_US
dc.subject.emtreeCommon carotid arteryen_US
dc.subject.emtreeDisease modelen_US
dc.subject.emtreeEnzymologyen_US
dc.subject.emtreeIschemic preconditioningen_US
dc.subject.emtreeLipid peroxidationen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeNewbornen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSprague dawley raten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAge factorsen_US
dc.subject.meshAnimals, newbornen_US
dc.subject.meshAntioxidantsen_US
dc.subject.meshBrainen_US
dc.subject.meshCarotid artery, commonen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshGlutathione peroxidaseen_US
dc.subject.meshHypoxia-ischemia, brainen_US
dc.subject.meshIschemic preconditioningen_US
dc.subject.meshLipid peroxidationen_US
dc.subject.meshMalondialdehydeen_US
dc.subject.meshOxidative stressen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshSuperoxide dismutaseen_US
dc.subject.scopusIschemic Preconditioning; Neuroprotection; Brain Ischemiaen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosSurgeryen_US
dc.titleEffects of hypoxic preconditioning in antioxidant enzyme activities in hypoxic-ischemic brain damage in immature ratsen_US
dc.title.alternativeHipoksik ön koşullamanın neonatal hipoksik-iskemik beyin hasarında antioksidan enzim aktivitelerine etkisitr_TR
dc.typeArticle

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