The initial fall in arterial pressure evoked by endotoxin is mediated by the ventrolateral periaqueductal gray

dc.contributor.authorMillington, William R.
dc.contributor.authorFeleder, Carlos
dc.contributor.buuauthorYılmaz, Mustafa Sertaç
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-9496-1475tr_TR
dc.contributor.researcheridAAH-1571-2021tr_TR
dc.contributor.scopusid8895544100tr_TR
dc.date.accessioned2023-04-11T08:02:49Z
dc.date.available2023-04-11T08:02:49Z
dc.date.issued2016-03-21
dc.description.abstractThis study tested the hypothesis that the initial fall in arterial pressure evoked by lipopolysaccharide (LPS) is mediated by the ventrolateral column of the midbrain periaqueductal gray region (vlPAG). To test this hypothesis, the local anaesthetic lidocaine (2%; 0.1L, 0.2L or 1.0L), the delta opioid receptor antagonist naltrindole (2nmol) or saline was microinjected into the vlPAG of isoflurane-anaesthetized rats bilaterally and LPS (1mg/kg) or saline was administered intravenously 2min later. Both lidocaine and naltrindole inhibited LPS-evoked hypotension significantly but did not affect arterial pressure in saline-treated control animals. Neither lidocaine nor naltrindole altered heart rate significantly in either LPS-treated or control animals. Microinjection of lidocaine or naltrindole into the dorsolateral PAG was ineffective. These data indicate that the vlPAG plays an important role in the initiation of endotoxic hypotension and further show that delta opioid receptors in the vlPAG participate in the response.en_US
dc.description.sponsorshipUnited States Department of Health & Human Servicesen_US
dc.description.sponsorshipNational Institutes of Health (NIH) - USAen_US
dc.description.sponsorshipNIH National Institute of Allergy & Infectious Diseases (NIAID) - R15AI072744en_US
dc.identifier.citationMillington, W. R. vd. (2016). "The initial fall in arterial pressure evoked by endotoxin is mediated by the ventrolateral periaqueductal gray". Clinical and Experimental Pharmacology and Physiology, 43(6), 612-615.en_US
dc.identifier.endpage615tr_TR
dc.identifier.issn1440-1681
dc.identifier.issue6tr_TR
dc.identifier.pubmed27009880tr_TR
dc.identifier.scopus2-s2.0-84964902052tr_TR
dc.identifier.startpage612tr_TR
dc.identifier.urihttps://doi.org/10.1111/1440-1681.12573
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/1440-1681.12573
dc.identifier.urihttp://hdl.handle.net/11452/32309
dc.identifier.volume43tr_TR
dc.identifier.wos000375936600004tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalClinical and Experimental Pharmacology and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectPhysiologyen_US
dc.subjectDelta receptoren_US
dc.subjectEndotoxinen_US
dc.subjectEndotoxin shocken_US
dc.subjectLipopolysaccharideen_US
dc.subjectOpioid receptoren_US
dc.subjectPeriaqueductal grayen_US
dc.subjectPreoptic areaen_US
dc.subjectAnterior hypothalamic areaen_US
dc.subjectSympathetic-nerve activityen_US
dc.subjectDelta-opioid receptorsen_US
dc.subjectCardiovascular-responsesen_US
dc.subjectInduced hypotensionen_US
dc.subjectProjection pathwayen_US
dc.subjectPreoptic areaen_US
dc.subjectRatsen_US
dc.subjectShocken_US
dc.subjectNucleusen_US
dc.subject.emtreeDelta opiate receptoren_US
dc.subject.emtreeEndotoxinen_US
dc.subject.emtreeIsofluraneen_US
dc.subject.emtreeLidocaineen_US
dc.subject.emtreeLipopolysaccharideen_US
dc.subject.emtreeNaltrindoleen_US
dc.subject.emtreeSodium chlorideen_US
dc.subject.emtreeEndotoxinen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeArterial pressureen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeHypotensionen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePeriaqueductal gray matteren_US
dc.subject.emtreeRaten_US
dc.subject.emtreeTreatment responseen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeArterial pressureen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeIntracerebroventricular drug administrationen_US
dc.subject.emtreePeriaqueductal gray matteren_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeSprague dawley raten_US
dc.subject.meshAnimalsen_US
dc.subject.meshArterial pressureen_US
dc.subject.meshEndotoxinsen_US
dc.subject.meshInjections, intraventricularen_US
dc.subject.meshLipopolysaccharidesen_US
dc.subject.meshMaleen_US
dc.subject.meshPeriaqueductal grayen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.scopusPeriaqueductal Gray; Animals; Escape Reactionen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.subject.wosPhysiologyen_US
dc.titleThe initial fall in arterial pressure evoked by endotoxin is mediated by the ventrolateral periaqueductal grayen_US
dc.typeArticle

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