Effects of intranigral vs intrastriatal fetal mesencephalic neural grafts on motor behavior disorders in a rat Parkinson model

dc.contributor.buuauthorGören, Bülent
dc.contributor.buuauthorKahveci, Nevzat
dc.contributor.buuauthorEyigör, Özhan
dc.contributor.buuauthorAlkan, Tülin
dc.contributor.buuauthorKorfalı, Ender
dc.contributor.buuauthorÖzlük, Kasım
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-3463-7483tr_TR
dc.contributor.orcid0000-0003-0841-8201tr_TR
dc.contributor.researcheridABE-5128-2020tr_TR
dc.contributor.researcheridAAH-1718-2021tr_TR
dc.contributor.researcheridAAG-7070-2021tr_TR
dc.contributor.scopusid6602543716tr_TR
dc.contributor.scopusid6602597846tr_TR
dc.contributor.scopusid6603109907tr_TR
dc.contributor.scopusid6601953747tr_TR
dc.contributor.scopusid7004641343tr_TR
dc.contributor.scopusid6602676331tr_TR
dc.date.accessioned2022-01-06T08:41:06Z
dc.date.available2022-01-06T08:41:06Z
dc.date.issued2005
dc.description.abstractBackground: Numerous experimental and clinical studies have shown that intrastriatal fetal mesencephalic grafts grow, survive, and reinnervate host brain tissue, resulting in partial recovery of motor deficits. In addition, pharmacological evidence indicates that these grafts increase dopamine secretion in lesioned brain. However, to date, no grafting method has completely restored the nigrostriatal pathway, and there is no consensus on optimal graft numbers or locations. This study compared outcomes with multiple striatal grafts vs a single intranigral graft in a rat model of Parkinson disease. Methods: Forty-one female Wistar rats weighing 200 to 250 g were used. First, baseline rotational behavior testing with amphetamine injection was done to identify each animal's dominant nigrostriatal pathway (left vs right hemisphere). Some rats then received a unilateral intranigral injection of 6-hydroxydopamine (4 mu L [8 mu g]) to produce the Parkinson model lesion, and rotational testing was repeated. One group of the lesioned rats received a single intranigral injection of suspended fetal ventral mesencephalic cells (n = 11), and another received multiple intrastriatal grafts of the same type (n = 11). Results: Both grafted groups showed significant improvement on rotational testing with amphetamine and apomorphine at 6 weeks "postgrafting" (P <.001 for "postlesioning" vs postgrafting results in each of the 2 groups); however, the animals with multiple intrastriatal grafts showed complete recovery from motor asymmetry, whereas the rats with single intranigral grafts showed only partial improvement. Conclusion: The findings indicate that multiple intrastriatal grafts result in significantly greater functional improvement than single intranigral grafts in this rat Parkinson model.en_US
dc.identifier.citationGören, B. vd. (2005). "Effects of intranigral vs intrastriatal fetal mesencephalic neural grafts on motor behavior disorders in a rat Parkinson model". Surgical Neurology, 64(2), 33-41.en_US
dc.identifier.endpage41tr_TR
dc.identifier.issn0090-3019
dc.identifier.issue2tr_TR
dc.identifier.pubmed16256839tr_TR
dc.identifier.scopus2-s2.0-27444433981tr_TR
dc.identifier.startpage33tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.surneu.2005.07.038
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0090301905005288
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/16256839/
dc.identifier.urihttp://hdl.handle.net/11452/23890
dc.identifier.volume64tr_TR
dc.identifier.wos000233321000008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.journalSurgical Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectSurgeryen_US
dc.subjectDrug-induced rotational behavioren_US
dc.subjectFetal ventral mesencephalic graftsen_US
dc.subjectIntrastriatal graftsen_US
dc.subjectNeural transplantationen_US
dc.subject6-hydroxydopamineen_US
dc.subjectRecovery following transplantationen_US
dc.subjectEmbryonic ventral mesencephalonen_US
dc.subjectNigrostriatal dopamine pathwayen_US
dc.subjectBilateral 6-ohda lesionsen_US
dc.subjectCell-suspension graftsen_US
dc.subjectSubstantia-nigraen_US
dc.subjectAdult-raten_US
dc.subjectNeurite growthre-innervationen_US
dc.subjectNeonatal ratsen_US
dc.subject.emtreeAmphetamineen_US
dc.subject.emtreeApomorphineen_US
dc.subject.emtreeOxidopamineen_US
dc.subject.emtreeAdrenergic receptor stimulating agenten_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBody weighten_US
dc.subject.emtreeCircling behavioren_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeConvalescenceen_US
dc.subject.emtreeDisease modelen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFetusen_US
dc.subject.emtreeFetus cellen_US
dc.subject.emtreeInjectionen_US
dc.subject.emtreeLeft hemisphereen_US
dc.subject.emtreeMesencephalonen_US
dc.subject.emtreeMotor dysfunctionen_US
dc.subject.emtreeNerve graften_US
dc.subject.emtreeNigroneostriatal systemen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeParkinson diseaseen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeRight hemisphereen_US
dc.subject.emtreeTreatment outcomeen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeCell transplantationen_US
dc.subject.emtreeCorpus striatumen_US
dc.subject.emtreeCytologyen_US
dc.subject.emtreeFetal tissue transplantationen_US
dc.subject.emtreeMesencephalonen_US
dc.subject.emtreeMethodologyen_US
dc.subject.emtreeMotor activityen_US
dc.subject.emtreePrenatal developmenten_US
dc.subject.emtreePsychological aspecten_US
dc.subject.emtreeSubstantia nigraen_US
dc.subject.emtreeTransplantationen_US
dc.subject.emtreeWistar raten_US
dc.subject.meshAdrenergic agentsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell transplantationen_US
dc.subject.meshCorpus striatumen_US
dc.subject.meshDisease modelsen_US
dc.subject.meshAnimalen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal tissue transplantationen_US
dc.subject.meshMesencephalonen_US
dc.subject.meshMotor activityen_US
dc.subject.meshOxidopamineen_US
dc.subject.meshParkinson diseaseen_US
dc.subject.meshRatsen_US
dc.subject.meshRats,wistaren_US
dc.subject.meshSubstantia nigraen_US
dc.subject.scopusDopaminergic Nerve Cell; Parkinson's Disease; Graft Survivalen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosSurgeryen_US
dc.titleEffects of intranigral vs intrastriatal fetal mesencephalic neural grafts on motor behavior disorders in a rat Parkinson modelen_US
dc.typeArticle
dc.wos.quartileQ2 (Surgery)en_US
dc.wos.quartileQ3 (Clinical neurology)en_US

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