The acute cardiorespiratory effects of centrally injected arachidonic acid; the mediation of prostaglandin E, D and F-2 alpha

dc.contributor.buuauthorErkan, Leman Gizem
dc.contributor.buuauthorAltınbaş, Burçin
dc.contributor.buuauthorGüvenç, Gökçen
dc.contributor.buuauthorAydın, Begüm
dc.contributor.buuauthorNiaz, Nasir
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.researcheridAAR-6815-2021tr_TR
dc.contributor.researcheridAAC-4975-2022tr_TR
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.scopusid56529371200tr_TR
dc.contributor.scopusid55356919300tr_TR
dc.contributor.scopusid56529426800tr_TR
dc.contributor.scopusid57194022849tr_TR
dc.contributor.scopusid57060367600tr_TR
dc.contributor.scopusid57192959734tr_TR
dc.date.accessioned2023-01-11T05:50:48Z
dc.date.available2023-01-11T05:50:48Z
dc.date.issued2017-04-18
dc.description.abstractArachidonic acid (AA), which is released from synaptic membrane phospholipid by neuroreceptor-initiated activation of phospholipase A(2), is abundant in the brain and works as a neurotransmitter and/or neuromodulator in the central nervous system. Recently we reported that centrally injected AA generated pressor and hyperventilation effects by activating thromboxane A(2) (TXA(2)) signaling pathway. The present study was designed to investigate the mediation of other metabolites of AA such as prostaglandin (PG) D, PGE and PGF(2 alpha), alongside TXA(2) in the AA-evoked cardiorespiratory effects in anaesthetized rats. Intracerebroventricular (i.c.v.) administration of AA caused pressor, bradycardic and hyperventilation responses by increasing pO(2) and decreasing pCO(2) in adult male anaesthetized Sprague Dawley rats. Pretreatment (i.c.v) with different doses of DP/EP prostanoid receptor antagonist, AH6809 or FP prostanoid receptor antagonist, PGF(2 alpha), dimethylamine partially blocked the cardiorespiratory and blood gas changes induced by AA. In conclusion, these data plainly report that central PGD, PGE or PGF(2 alpha) might mediate, at least partly, centrally administered AA-evoked cardiorespiratory and blood gas responses.en_US
dc.identifier.citationErkan, L. G. vd. (2017). ''The acute cardiorespiratory effects of centrally injected arachidonic acid; the mediation of prostaglandin E, D and F-2 alpha''. Respiratory Physiology and Neurobiology, 242, 117-124.en_US
dc.identifier.endpage124tr_TR
dc.identifier.issn1569-9048
dc.identifier.pubmed28445779tr_TR
dc.identifier.scopus2-s2.0-85018293740tr_TR
dc.identifier.startpage117tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.resp.2017.04.006
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1569904816302774
dc.identifier.uri1878-1519
dc.identifier.urihttp://hdl.handle.net/11452/30372
dc.identifier.volume242tr_TR
dc.identifier.wos000403519200018tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.journalRespiratory Physiology and Neurobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitak1140093tr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhysiologyen_US
dc.subjectRespiratory systemen_US
dc.subjectArachidonic aciden_US
dc.subjectHeart rateen_US
dc.subjectIntracerebroventricularen_US
dc.subjectMean blood pressureen_US
dc.subjectPartial carbon dioxide pressureen_US
dc.subjectPartial oxygen pressureen_US
dc.subjectPGDen_US
dc.subjectPGEen_US
dc.subjectPGF2αen_US
dc.subjectRespiratory minute ventilationen_US
dc.subjectRespiratory rateen_US
dc.subjectTidal volumeen_US
dc.subjectThromboxane signaling pathwayen_US
dc.subjectHemorrhaged hypotensive ratsen_US
dc.subjectPhospholipase a(2) activatoren_US
dc.subjectCentral histaminergic systemen_US
dc.subjectBreathing movementsen_US
dc.subjectCardiovascular regulationen_US
dc.subjectPeripheral mechanismsen_US
dc.subjectRespiratory systemen_US
dc.subjectNormotensive ratsen_US
dc.subjectFetal sheepen_US
dc.subject.emtree6 isopropoxy 9 oxo 2 xanthenecarboxylic aciden_US
dc.subject.emtreeArachidonic aciden_US
dc.subject.emtreeDimethylamineen_US
dc.subject.emtreeProstaglandin F2 alphaen_US
dc.subject.emtree6-isopropoxy-9-oxoxanthene-2-carboxylic aciden_US
dc.subject.emtreeArachidonic aciden_US
dc.subject.emtreeCardiovascular agenten_US
dc.subject.emtreeProstaglandin D.en_US
dc.subject.emtreeProstaglandin E.en_US
dc.subject.emtreeProstaglandin F.en_US
dc.subject.emtreeProstaglandin receptoren_US
dc.subject.emtreeRespiratory tract agenten_US
dc.subject.emtreeThromboxane A2en_US
dc.subject.emtreeXanthone derivativeen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood gasen_US
dc.subject.emtreeBradycardiaen_US
dc.subject.emtreeCarbon dioxide tensionen_US
dc.subject.emtreeCardiovascular effecten_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeHyperventilationen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOxygen tensionen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeRespiratory functionen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeAntagonists and inhibitorsen_US
dc.subject.emtreeBlood gas analysisen_US
dc.subject.emtreeBlood pressureen_US
dc.subject.emtreeBreathingen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeIntracerebroventricular drug administrationen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeSprague dawley raten_US
dc.subject.emtreeTime factoren_US
dc.subject.meshAnimalsen_US
dc.subject.meshArachidonic aciden_US
dc.subject.meshBlood gas analysisen_US
dc.subject.meshBlood pressureen_US
dc.subject.meshCardiovascular agentsen_US
dc.subject.meshInfusions, intraventricularen_US
dc.subject.meshMaleen_US
dc.subject.meshProstaglandins D.en_US
dc.subject.meshProstaglandins E.en_US
dc.subject.meshProstaglandins F.en_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshReceptors, prostaglandinen_US
dc.subject.meshRespirationen_US
dc.subject.meshRespiratory system agentsen_US
dc.subject.meshThromboxane A2en_US
dc.subject.meshTime factorsen_US
dc.subject.meshXanthonesen_US
dc.subject.scopusHistamine H4 Receptors; Thioperamide; Intracerebroventricular Drug Administrationen_US
dc.subject.wosPhysiologyen_US
dc.subject.wosRespiratory systemen_US
dc.titleThe acute cardiorespiratory effects of centrally injected arachidonic acid; the mediation of prostaglandin E, D and F-2 alphaen_US
dc.typeArticle
dc.wos.quartileQ3 (Physiology)en_US
dc.wos.quartileQ4 (Respiratory system)en_US

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