Exenatide treatment causes suppression of serum ghrelin levels following mixed meal test in obese diabetic women
dc.contributor.author | Topyıldız, Figen | |
dc.contributor.author | Kıyıcı, Sinem | |
dc.contributor.author | Güçlü, Metin | |
dc.contributor.author | Kısakol, Gürcan | |
dc.contributor.buuauthor | Gül, Zülfiye | |
dc.contributor.buuauthor | Sıgırlı, Deniz | |
dc.contributor.buuauthor | Çavun, Sinan | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Eczacılık Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-8872-0074 | tr_TR |
dc.contributor.researcherid | AAF-9939-2020 | tr_TR |
dc.contributor.researcherid | AAA-7472-2021 | tr_TR |
dc.contributor.researcherid | AAC-9702-2019 | tr_TR |
dc.contributor.scopusid | 56086542900 | tr_TR |
dc.contributor.scopusid | 24482063400 | tr_TR |
dc.contributor.scopusid | 6507468595 | tr_TR |
dc.date.accessioned | 2022-12-19T12:15:16Z | |
dc.date.available | 2022-12-19T12:15:16Z | |
dc.date.issued | 2016-01-21 | |
dc.description.abstract | Aim. To investigate the effect of exenatide treatment on serum ghrelin levels in obese female patients with type 2 diabetes mellitus. Methods. Fourteen female patients with type 2 diabetes mellitus being treated with metformin and exenatide were enrolled. A mixed meal test was applied to the patients while continuing with their daily medications. Blood samples were taken before and at 60, 120, and 180 minutes following mixed meal test to measure serum total ghrelin, glucose, and insulin levels. The following week, exenatide treatment of the patients was paused for 24 hours and the same experimental procedures were repeated. Results. Serum ghrelin levels were suppressed significantly at 180 minutes with exenatide treatment compared with baseline (294.4 +/- 57.5 versus 234.5 +/- 59.4 pg/mL) (p < 0.001). Serum ghrelin levels at 180 minutes were statistically different when percentage change in serum ghrelin levels after mixed meal tests with and without exenatide usage were compared (p = 0.001). Estimated total area under the curve values for serum ghrelin concentrations was also significantly lower with exenatide compared with omitted treatment (p = 0.035). Conclusion. These results suggest that the effect of exenatide on weight loss may be related with the suppression of serum ghrelin levels, which is an orexigenic peptide. | en_US |
dc.identifier.citation | Topyıldız, F. vd. (2016). "Exenatide treatment causes suppression of serum ghrelin levels following mixed meal test in obese diabetic women". ed. E. Randell, Journal of Diabetes Research, 2016. | en_US |
dc.identifier.issn | 2314-6745 | |
dc.identifier.issn | 2314-6753 | |
dc.identifier.pubmed | 26998491 | tr_TR |
dc.identifier.scopus | 2-s2.0-84960967871 | tr_TR |
dc.identifier.uri | https://doi.org/10.1155/2016/1309502 | |
dc.identifier.uri | https://www.hindawi.com/journals/jdr/2016/1309502/ | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779845/ | |
dc.identifier.uri | http://hdl.handle.net/11452/29960 | |
dc.identifier.volume | 2016 | tr_TR |
dc.identifier.wos | 000374053700001 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Hindawi | en_US |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | Journal of Diabetes Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Endocrinology & metabolism | en_US |
dc.subject | Research & experimental medicine | en_US |
dc.subject | Gastric-acid-secretion | en_US |
dc.subject | Plasma ghrelin | en_US |
dc.subject | Glycemic control | en_US |
dc.subject | Insulin | en_US |
dc.subject | Peptide | en_US |
dc.subject | Exendin-4 | en_US |
dc.subject | Metformin | en_US |
dc.subject | Weight | en_US |
dc.subject | Glp-1 | en_US |
dc.subject | Therapies | en_US |
dc.subject.emtree | Exendin 4 | en_US |
dc.subject.emtree | Ghrelin | en_US |
dc.subject.emtree | Glucose | en_US |
dc.subject.emtree | Insulin | en_US |
dc.subject.emtree | Metformin | en_US |
dc.subject.emtree | Antidiabetic agent | en_US |
dc.subject.emtree | Biological marker | en_US |
dc.subject.emtree | GHRL protein, human | en_US |
dc.subject.emtree | Incretin | en_US |
dc.subject.emtree | Peptide | en_US |
dc.subject.emtree | Venom | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Area under the curve | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Blood sampling | en_US |
dc.subject.emtree | Body mass | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Clinical trial | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Hormone blood level | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Non insulin dependent diabetes mellitus | en_US |
dc.subject.emtree | Obesity | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Test meal | en_US |
dc.subject.emtree | Treatment duration | en_US |
dc.subject.emtree | Waist circumference | en_US |
dc.subject.emtree | Weight reduction | en_US |
dc.subject.emtree | Blood | en_US |
dc.subject.emtree | Cerebrospinal fluid | en_US |
dc.subject.emtree | Combination drug therapy | en_US |
dc.subject.emtree | Complication | en_US |
dc.subject.emtree | Cross-sectional study | en_US |
dc.subject.emtree | Diabetes mellitus, type 2 | en_US |
dc.subject.emtree | Down regulation | en_US |
dc.subject.emtree | Drug effects | en_US |
dc.subject.emtree | Eating | en_US |
dc.subject.emtree | Middle aged | en_US |
dc.subject.emtree | Obesity | en_US |
dc.subject.emtree | Postprandial state | en_US |
dc.subject.emtree | Prospective study | en_US |
dc.subject.emtree | Time factor | en_US |
dc.subject.emtree | Treatment outcome | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Biomarkers | en_US |
dc.subject.mesh | Cross-sectional studies | en_US |
dc.subject.mesh | Diabetes mellitus, type 2 | en_US |
dc.subject.mesh | Down-regulation | en_US |
dc.subject.mesh | Drug therapy, combination | en_US |
dc.subject.mesh | Eating | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Ghrelin | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hypoglycemic agents | en_US |
dc.subject.mesh | Incretins | en_US |
dc.subject.mesh | Metformin | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Obesity | en_US |
dc.subject.mesh | Peptides | en_US |
dc.subject.mesh | Postprandial period | en_US |
dc.subject.mesh | Prospective studies | en_US |
dc.subject.mesh | Time factors | en_US |
dc.subject.mesh | Treatment outcome | en_US |
dc.subject.mesh | Venoms | en_US |
dc.subject.mesh | Weight loss | en_US |
dc.subject.scopus | Ghrelin Receptors; Acyltransferases; Eating | en_US |
dc.subject.wos | Endocrinology & metabolism | en_US |
dc.subject.wos | Medicine, research & experimental | en_US |
dc.title | Exenatide treatment causes suppression of serum ghrelin levels following mixed meal test in obese diabetic women | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 (Endocrinology & metabolism) | en_US |
dc.wos.quartile | Q2 (Medicine, research & experimental) | en_US |