Hypovolemic hemorrhage induces Fos expression in the rat hypothalamus: Evidence for involvement of the lateral hypothalamus in the decompensatory phase of hemorrhage
dc.contributor.author | Millington, William R. | |
dc.contributor.buuauthor | Göktalay, Gökhan | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0001-6261-4233 | tr_TR |
dc.contributor.researcherid | AAH-1448-2021 | tr_TR |
dc.contributor.scopusid | 6508023759 | tr_TR |
dc.date.accessioned | 2023-04-14T07:22:53Z | |
dc.date.available | 2023-04-14T07:22:53Z | |
dc.date.issued | 2016-02-27 | |
dc.description.abstract | This study tested the hypothesis that the hypothalamus participates in the decompensatory phase of hemorrhage by measuring Fos immunoreactivity and by inhibiting neuronal activity in selected hypothalamic nuclei with lidocaine or cobalt chloride. Previously, we reported that inactivation of the arcuate nucleus inhibited, but did not fully prevent, the fall in arterial pressure evoked by hypotensive hemorrhage. Here, we report that hemorrhage (2.2 ml/100 g body weight over 20 min) induced Fos expression in a high percentage of cells in the paraventricular, supraoptic and arcuate nuclei of the hypothalamus as shown previously. Lower densities of Fos immunoreactive cells were also found in the medial preoptic area (mPOA), anterior hypothalamus, lateral hypothalamus (LH), dorsomedial hypothalamus, ventromedial hypothalamus (VMH) and posterior hypothalamus. Bilateral injection of lidocaine (2%; 0.1 mu l or 0.3 mu l) or cobalt chloride (5 mM; 0.3 mu l) into the tuberal portion of the LH immediately before hemorrhage was initiated reduced the magnitude of hemorrhagic hypotension and bradycardia significantly. Lidocaine injection into the VMH also attenuated the fall in arterial pressure and heart rate evoked by hemorrhage although inactivation of the mPOA or rostral LH was ineffective. These findings indicate that hemorrhage activates neurons throughout much of the hypothalamus and that a relatively broad area of the hypothalamus, extending from the arcuate nucleus laterally through the caudal VMH and tuberal LH, plays an important role in the decompensatory phase of hemorrhage. | en_US |
dc.description.sponsorship | Office of Naval Research - N00014-00-1-0056 | en_US |
dc.identifier.citation | Göktalay, G. ve Millington, W. R. (2016). "Hypovolemic hemorrhage induces Fos expression in the rat hypothalamus: Evidence for involvement of the lateral hypothalamus in the decompensatory phase of hemorrhage". Neuroscience, 322, 464-478. | en_US |
dc.identifier.endpage | 478 | tr_TR |
dc.identifier.issn | 0306-4522 | |
dc.identifier.issn | 1873-7544 | |
dc.identifier.pubmed | 26947128 | tr_TR |
dc.identifier.scopus | 2-s2.0-84960153439 | tr_TR |
dc.identifier.startpage | 464 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.neuroscience.2016.02.068 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0306452216002177 | |
dc.identifier.uri | http://hdl.handle.net/11452/32390 | |
dc.identifier.volume | 322 | tr_TR |
dc.identifier.wos | 000372349800040 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.journal | Neuroscience | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Neurosciences & neurology | en_US |
dc.subject | Hemorrhagic shock | en_US |
dc.subject | Lateral hypothalamus | en_US |
dc.subject | Ventromedial hypothalamus | en_US |
dc.subject | Arcuate nucleus | en_US |
dc.subject | Fos immunoreactivity | en_US |
dc.subject | Ventrolateral periaqueductal gray | en_US |
dc.subject | Nucleus-tractus-solitarius | en_US |
dc.subject | Delta-opioid receptors | en_US |
dc.subject | Vulgaris-leukoagglutinin | en_US |
dc.subject | Cardiovascular-responses | en_US |
dc.subject | Anterior hypothalamus | en_US |
dc.subject | Efferent connections | en_US |
dc.subject | L-glutamate | en_US |
dc.subject | Brain-stem | en_US |
dc.subject | Excitatory projections | en_US |
dc.subject | Hemorrhage | en_US |
dc.subject.emtree | Cobalt chloride | en_US |
dc.subject.emtree | Lidocaine | en_US |
dc.subject.emtree | Protein fos | en_US |
dc.subject.emtree | Cobalt | en_US |
dc.subject.emtree | Hemostatic agent | en_US |
dc.subject.emtree | Lidocaine | en_US |
dc.subject.emtree | Protein c fos | en_US |
dc.subject.emtree | Animal cell | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Anterior hypothalamus | en_US |
dc.subject.emtree | Arcuate nucleus | en_US |
dc.subject.emtree | Arterial pressure | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Bleeding | en_US |
dc.subject.emtree | Body weight | en_US |
dc.subject.emtree | Bradycardia | en_US |
dc.subject.emtree | Brain function | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Disease duration | en_US |
dc.subject.emtree | Dorso medial hypothalamus | en_US |
dc.subject.emtree | Evoked response | en_US |
dc.subject.emtree | Heart rate | en_US |
dc.subject.emtree | Hypotension | en_US |
dc.subject.emtree | Hypothalamic paraventricular nucleus | en_US |
dc.subject.emtree | Hypothalamus | en_US |
dc.subject.emtree | Hypovolemia | en_US |
dc.subject.emtree | Hypovolemic hemorrhage | en_US |
dc.subject.emtree | Immunoreactivity | en_US |
dc.subject.emtree | Lateral hypothalamus | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Medial preoptic area | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Pathogenesis | en_US |
dc.subject.emtree | Posterior hypothalamus | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Protein expression | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Synapse | en_US |
dc.subject.emtree | Zona incerta | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Bleeding | en_US |
dc.subject.emtree | Disease model | en_US |
dc.subject.emtree | Hypovolemia | en_US |
dc.subject.emtree | Metabolism | en_US |
dc.subject.emtree | Nerve cell | en_US |
dc.subject.emtree | Pathology | en_US |
dc.subject.emtree | Pathophysiology | en_US |
dc.subject.emtree | Sprague dawley rat | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bradycardia | en_US |
dc.subject.mesh | Cobalt | en_US |
dc.subject.mesh | Disease models, animal | en_US |
dc.subject.mesh | Hemorrhage | en_US |
dc.subject.mesh | Hemostatics | en_US |
dc.subject.mesh | Hypothalamus | en_US |
dc.subject.mesh | Hypovolemia | en_US |
dc.subject.mesh | Lidocaine | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Neurons | en_US |
dc.subject.mesh | Proto-oncogene proteins c-fos | en_US |
dc.subject.mesh | Rats, sprague-dawley | en_US |
dc.subject.scopus | Periaqueductal Gray; Animals; Escape Reaction | en_US |
dc.subject.wos | Neurosciences | en_US |
dc.title | Hypovolemic hemorrhage induces Fos expression in the rat hypothalamus: Evidence for involvement of the lateral hypothalamus in the decompensatory phase of hemorrhage | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 | en_US |
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