Apoptosis: Why and how does it occur in biology?
dc.contributor.author | Açılan, Ceyda | |
dc.contributor.author | Yılmaz, Yusuf | |
dc.contributor.buuauthor | Ulukaya, Engin | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya. | tr_TR |
dc.contributor.researcherid | K-5792-2018 | tr_TR |
dc.contributor.scopusid | 6602927353 | tr_TR |
dc.date.accessioned | 2021-10-21T11:25:49Z | |
dc.date.available | 2021-10-21T11:25:49Z | |
dc.date.issued | 2011-08 | |
dc.description.abstract | The literature on apoptosis has grown tremendously in recent years, and the mechanisms that are involved in this programmed cell death pathway have been enlightened. It is now known that apoptosis takes place starting from early development to adult stage for the homeostasis of multicellular organisms, during disease development and in response to different stimuli in many different systems. In this review, we attempted to summarize the current knowledge on the circumstances and the mechanisms that lead to induction of apoptosis, while going over the molecular details of the modulator and mediators of apoptosis as well as drawing the lines between programmed and non-programmed cell death pathways. The review will particularly focus on Bcl-2 family proteins, the role of different caspases in the process of apoptosis, and their inhibitors as well as the importance of apoptosis during different disease states. Understanding the molecular mechanisms involved in apoptosis better will make a big impact on human diseases, particularly cancer, and its management in the clinics. | en_US |
dc.identifier.citation | Ulukaya, E. vd. (2011).“Apoptosis: Why and how does it occur in biology?”. Cell Biochemistry and Function, 29(6), 468-480. | en_US |
dc.identifier.endpage | 480 | tr_TR |
dc.identifier.issn | 0263-6484 | |
dc.identifier.issn | 1099-0844 | |
dc.identifier.issue | 6 | tr_TR |
dc.identifier.pubmed | 21773978 | tr_TR |
dc.identifier.scopus | 2-s2.0-80051668693 | tr_TR |
dc.identifier.startpage | 468 | tr_TR |
dc.identifier.uri | https://doi.org/10.1002/cbf.1774 | |
dc.identifier.uri | http://hdl.handle.net/11452/22428 | |
dc.identifier.volume | 29 | tr_TR |
dc.identifier.wos | 000294267100005 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | Cell Biochemıstry and Function | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Programmed cell death | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Necrosis | en_US |
dc.subject | Apoptosis-inducing factors (Aifs) | en_US |
dc.subject | Caspaseinhibitor of apoptosis proteins (Iaps) | en_US |
dc.subject | Bcl-2 family | en_US |
dc.subject | X-Linked inhibitor | en_US |
dc.subject | Apo-1/Fas receptor/ligand system | en_US |
dc.subject | Caspase-cleaved cytokeratin-18 | en_US |
dc.subject | Bcl-2 family proteins | en_US |
dc.subject | Cells in-vitro | en_US |
dc.subject | Fas-ligand | en_US |
dc.subject | Cytochrome-C | en_US |
dc.subject | Mitochondrial apoptosis | en_US |
dc.subject | Chromosome-segregation | en_US |
dc.subject | Bh3-only proteins | en_US |
dc.subject | Intracisternal a-particles | en_US |
dc.subject.emtree | 2 morpholino 8 phenylchromone | en_US |
dc.subject.emtree | Antineoplastic agent | en_US |
dc.subject.emtree | Apoptosis inhibitör | en_US |
dc.subject.emtree | BAG 1 protein; BIM protein | en_US |
dc.subject.emtree | Caspase | en_US |
dc.subject.emtree | Caspase inhibitor | en_US |
dc.subject.emtree | Cellular apoptosis susceptibility protein | en_US |
dc.subject.emtree | Ceramide | en_US |
dc.subject.emtree | Fas antibody | en_US |
dc.subject.emtree | Fas associated death domain protein | en_US |
dc.subject.emtree | Granzyme | en_US |
dc.subject.emtree | HLA DR3 antigen | en_US |
dc.subject.emtree | HLA DR4 antigen | en_US |
dc.subject.emtree | HLA DR5 antigen | en_US |
dc.subject.emtree | Navitoclax | en_US |
dc.subject.emtree | Neuronal apoptosis inhibitory protein | en_US |
dc.subject.emtree | Nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase | en_US |
dc.subject.emtree | Obatoclax | en_US |
dc.subject.emtree | Perforin | en_US |
dc.subject.emtree | Protein BAD | en_US |
dc.subject.emtree | Protein bax | en_US |
dc.subject.emtree | Protein bcl 2 | en_US |
dc.subject.emtree | Protein Bid | en_US |
dc.subject.emtree | Protein kinase B inhibitor | en_US |
dc.subject.emtree | Protein p53 | en_US |
dc.subject.emtree | Survivin | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Unindexed drug | en_US |
dc.subject.emtree | X linked inhibitor of apoptosis | en_US |
dc.subject.emtree | X linked inhibitor of apoptosis antagonist | en_US |
dc.subject.emtree | Acquired immune deficiency syndrome | en_US |
dc.subject.emtree | Apoptosis | en_US |
dc.subject.emtree | Caenorhabditis elegans | en_US |
dc.subject.emtree | Cancer chemotherapy | en_US |
dc.subject.emtree | Carcinogenesis | en_US |
dc.subject.emtree | Cell activation | en_US |
dc.subject.emtree | Cell cycle | en_US |
dc.subject.emtree | Cell death | en_US |
dc.subject.emtree | Cell division | en_US |
dc.subject.emtree | Cell growth | en_US |
dc.subject.emtree | Cell protection | en_US |
dc.subject.emtree | Cell stress | en_US |
dc.subject.emtree | Cell survival | en_US |
dc.subject.emtree | Cell swelling | en_US |
dc.subject.emtree | Cytolysis | en_US |
dc.subject.emtree | Cytotoxic T lymphocyte | en_US |
dc.subject.emtree | Dephosphorylation | en_US |
dc.subject.emtree | Disease course | en_US |
dc.subject.emtree | DNA damage | en_US |
dc.subject.emtree | DNA fragmentation | en_US |
dc.subject.emtree | Drug binding | en_US |
dc.subject.emtree | Drug mechanism | en_US |
dc.subject.emtree | Drug synthesis | en_US |
dc.subject.emtree | Endometrium | en_US |
dc.subject.emtree | Enzyme activation | en_US |
dc.subject.emtree | Enzyme substrate | en_US |
dc.subject.emtree | Epstein barr virüs | en_US |
dc.subject.emtree | Genetic transcription | en_US |
dc.subject.emtree | Homeostasis | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | In vitro study | en_US |
dc.subject.emtree | Insulin dependent diabetes mellitus | en_US |
dc.subject.emtree | Internucleosomal DNA fragmentation | en_US |
dc.subject.emtree | Keratinocyte | en_US |
dc.subject.emtree | Mitochondrial activation | en_US |
dc.subject.emtree | Mitosis | en_US |
dc.subject.emtree | Molecular biology | en_US |
dc.subject.emtree | Multiple sclerosis | en_US |
dc.subject.emtree | Natural killer cell | en_US |
dc.subject.emtree | Natural killer T cell | en_US |
dc.subject.emtree | Necrosis | en_US |
dc.subject.emtree | Neoplasm | en_US |
dc.subject.emtree | Nerve cell | en_US |
dc.subject.emtree | Nerve degeneration | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Oligomerization | en_US |
dc.subject.emtree | Organ transplantation | en_US |
dc.subject.emtree | Oxidative stress | en_US |
dc.subject.emtree | Papilloma virüs | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Protein cleavage | en_US |
dc.subject.emtree | Protein dephosphorylation | en_US |
dc.subject.emtree | Protein secretion | en_US |
dc.subject.emtree | Review | en_US |
dc.subject.emtree | Thymus | en_US |
dc.subject.emtree | Umor necrosis factor receptor associated periodic syndrome | en_US |
dc.subject.mesh | Apoptosis | en_US |
dc.subject.mesh | Apoptosis inducing factor | en_US |
dc.subject.mesh | Caspases | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Inhibitor of apoptosis proteins | en_US |
dc.subject.mesh | Necrosis | en_US |
dc.subject.mesh | Proto-Oncogene proteins c-bcl-2 | en_US |
dc.subject.mesh | Signal transduction | en_US |
dc.subject.scopus | Mitochondrial Membranes; Bcl-2; Bax Protein (53-86) | en_US |
dc.subject.wos | Biochemistry & molecular biology | en_US |
dc.subject.wos | Cell biology | en_US |
dc.title | Apoptosis: Why and how does it occur in biology? | en_US |
dc.type | Review | |
dc.wos.quartile | Q4 (Cell biology) | en_US |
dc.wos.quartile | Q3 (Biochemistry & molecular biology) | en_US |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: