Investigation of the genotoxic effect in bone marrow of swiss albino mice exposed long-term to pyrimethamine
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Date
2002
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Wiley Liss
Abstract
In the present study, we investigated the genotoxic effect of pyrimethamine, which is a drug used in the therapy of toxoplasmosis and malaria, in bone marrow cells of Swiss albino mice exposed to three doses (1, 4, 8 mg/kg) of this agent for eight months orally in vivo. We used a chromosome analysis and micronucleus test for evaluation of genotoxic effect. While a statistically significant change was not determined in numerical chromosome abnormalities, structural chromosome aberrations and micronuclei were increased in a dose-dependent manner by cytogenetic and statistical evaluations.
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Keywords
Bone marrow, Chromosome aberrations, Micronucleus, Pyrimethamine, Swiss albino mice, Common fragile sites, In-vivo mouse, Fhit gene, Chromosome-aberrations, lymphocyte-cultures, Spindle poisons, Chl cells, Expression, Induction, Cancer, Oncology, Genetics & heredity, Toxicology
Citation
Tunca, B. vd. (2002). "Investigation of the genotoxic effect in bone marrow of swiss albino mice exposed long-term to pyrimethamine". Teratogenesis Carcinogenesis and Mutagenesıs, 22(6), 393-402.