Water-soluble binary and ternary palladium(II) complexes containing amino acids and intercalating ligands: Synthesis, characterization, biomolecular interactions and cytotoxicities
dc.contributor.author | Sahin, Onur | |
dc.contributor.buuauthor | Inci, Duygu | |
dc.contributor.buuauthor | Aydin, Rahmiye | |
dc.contributor.buuauthor | Vatan, Ozgür | |
dc.contributor.buuauthor | Cinkılıc, Nilüfer | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji/Genel Biyoloji Bölümü. | tr_TR |
dc.contributor.orcid | 0000-0003-4944-0181 | tr_TR |
dc.contributor.orcid | 0000-0002-0483-9642 | tr_TR |
dc.contributor.orcid | 0000-0002-7687-3284 | tr_TR |
dc.contributor.orcid | 0000-0002-3595-6286 | tr_TR |
dc.contributor.researcherid | G-2201-2019 | tr_TR |
dc.contributor.researcherid | O-7508-2015 | tr_TR |
dc.contributor.researcherid | AAH-5296-2021 | tr_TR |
dc.contributor.researcherid | AAH-8936-2021 | tr_TR |
dc.contributor.scopusid | 55082306300 | tr_TR |
dc.contributor.scopusid | 56261495600 | tr_TR |
dc.contributor.scopusid | 16235098100 | tr_TR |
dc.contributor.scopusid | 26533892300 | tr_TR |
dc.date.accessioned | 2024-02-12T08:00:40Z | |
dc.date.available | 2024-02-12T08:00:40Z | |
dc.date.issued | 2019-03-28 | |
dc.description.abstract | In this study, six water soluble cationic binary (1-3) palladium() complexes of the type [PdA(2)](NO3)(2)(n - 1)H2O and ternary (4-6) palladium() complexes of the type [PdA(amino acid)](NO3)(n - 1)H2O, where A is 1,10-phenanthroline (phen) (1, 4, 6), 5-methyl-1,10-phenanthroline (5-mphen) (2, 5), and 3,4,7,8-tetramethyl-1,10-phenanthroline (tmphen) (3) and the amino acid is l-tyrosine (tyr) (4, 5) and glycine (gly) (6), have been synthesized and characterized using CHN elemental analyses, ATR-FT-MIR, H-1 NMR and C-13 NMR and single-crystal X-ray diffraction techniques. The interaction of the complexes with calf thymus DNA (CT-DNA) was investigated using electronic absorption spectral, ethidium bromide (EB) and Hoechst 33258 (HO) displacement assays and thermal denaturation. The pUC19 DNA cleavage activity of the complexes was investigated in the absence and presence of external agents by agarose gel electrophoresis. Quenching of the tryptophan and tyrosine residues of bovine serum albumin (BSA) by the complexes was found to be static. Furthermore, the in vitro cytotoxic effect of the complexes was examined on human tumor cell lines (Caco-2, A549, and MCF-7) and healthy cells (BEAS-2B). All the complexes exhibited different cytotoxic activities. | en_US |
dc.description.sponsorship | ||
dc.identifier.citation | Inci, D. vd. (2019). ''Water-soluble binary and ternary palladium(II) complexes containing amino acids and intercalating ligands: Synthesis, characterization, biomolecular interactions and cytotoxicities''. New Journal of Chemistry, 43(12), 4681-4697. | en_US |
dc.identifier.endpage | 4697 | tr_TR |
dc.identifier.issn | 1144-0546 | |
dc.identifier.issn | 1369-9261 | |
dc.identifier.issue | 12 | tr_TR |
dc.identifier.pubmed | ||
dc.identifier.scopus | 2-s2.0-85063220833 | tr_TR |
dc.identifier.startpage | 4681 | tr_TR |
dc.identifier.uri | https://doi.org/10.1039/c8nj05934a | en_US |
dc.identifier.uri | https://hdl.handle.net/11452/39613 | en_US |
dc.identifier.volume | 43 | tr_TR |
dc.identifier.wos | 000462541900003 | tr_TR |
dc.indexed.pubmed | ||
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Royal Sciety | en_US |
dc.relation.bap | (OUAP (F)-2015/14) | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | New Journal of Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.relation.tubitak | 2211-C | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Bovine serum-albumin | en_US |
dc.subject | Double-strand dna | en_US |
dc.subject | Copper(II) complex | en_US |
dc.subject | In-vitro | en_US |
dc.subject | Substituted 1,10-phenanthrolines | en_US |
dc.subject | Platinum(II) complexes | en_US |
dc.subject | Crystal-structure | en_US |
dc.subject | Bsa binding | en_US |
dc.subject | Derivaties | en_US |
dc.subject | Phenanthroline | en_US |
dc.subject.emtree | 1,10 phenanthroline | en_US |
dc.subject.emtree | 4 [5 (4 methyl 1 piperazinyl)[2,5' bi 1h benzimidazol] 2' yl]phenol | en_US |
dc.subject.emtree | Amino acid | en_US |
dc.subject.emtree | Bovine serum albumin | en_US |
dc.subject.emtree | Carboplatin | en_US |
dc.subject.emtree | Cisplatin | en_US |
dc.subject.emtree | Dna | en_US |
dc.subject.emtree | Ethidium bromide | en_US |
dc.subject.emtree | Glycine | en_US |
dc.subject.emtree | Hydrogen | en_US |
dc.subject.emtree | Hydroxyurea | en_US |
dc.subject.emtree | Ligand | en_US |
dc.subject.emtree | Oxaliplatin | en_US |
dc.subject.emtree | Palladium complex | en_US |
dc.subject.emtree | Phenanthroline | en_US |
dc.subject.emtree | Transplatin | en_US |
dc.subject.emtree | Tryptophan | en_US |
dc.subject.emtree | Tyrosine | en_US |
dc.subject.emtree | Water | en_US |
dc.subject.emtree | A-549 cell line | en_US |
dc.subject.emtree | Absorption spectroscopy | en_US |
dc.subject.emtree | Agar gel electrophoresis | en_US |
dc.subject.emtree | Antineoplastic activity | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Binding affinity | en_US |
dc.subject.emtree | Binding site | en_US |
dc.subject.emtree | Caco-2 cell line | en_US |
dc.subject.emtree | Carbon nuclear magnetic resonance | en_US |
dc.subject.emtree | Chemical structure | en_US |
dc.subject.emtree | Complex formation | en_US |
dc.subject.emtree | Conformational transition | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Crystal structure | en_US |
dc.subject.emtree | Cytotoxicity | en_US |
dc.subject.emtree | Denaturation | en_US |
dc.subject.emtree | DNA binding | en_US |
dc.subject.emtree | DNA cleavage | en_US |
dc.subject.emtree | DNA helix | en_US |
dc.subject.emtree | Drug synthesis | en_US |
dc.subject.emtree | Elemental analysis | en_US |
dc.subject.emtree | Fluorescence | en_US |
dc.subject.emtree | Fluorescence resonance energy transfer | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Human cell | en_US |
dc.subject.emtree | Hydrogen bond | en_US |
dc.subject.emtree | IC50 | en_US |
dc.subject.emtree | In vitro study | en_US |
dc.subject.emtree | Interactions with DNA | en_US |
dc.subject.emtree | MCF-7 cell line | en_US |
dc.subject.emtree | Molecular interaction | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Proton nuclear magnetic resonance | en_US |
dc.subject.emtree | Rate constant | en_US |
dc.subject.emtree | Solubility | en_US |
dc.subject.emtree | Spectrofluorometry | en_US |
dc.subject.emtree | Static electricity | en_US |
dc.subject.emtree | Stereospecificity | en_US |
dc.subject.emtree | Temperature dependence | en_US |
dc.subject.emtree | Thymus | en_US |
dc.subject.emtree | X ray diffraction | en_US |
dc.subject.emtree | XTT assay | en_US |
dc.subject.scopus | Complex; Viscometry; Schiff Bases | en_US |
dc.subject.wos | Chemistry, multidisciplinary | en_US |
dc.title | Water-soluble binary and ternary palladium(II) complexes containing amino acids and intercalating ligands: Synthesis, characterization, biomolecular interactions and cytotoxicities | en_US |
dc.type | Article | en_US |
dc.wos.quartile | Q2 | en_US |
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