Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia

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dc.contributor.authorAtik, Yeliz
dc.contributor.authorUsubütün, Alp
dc.contributor.authorErtürk, Fatma Yılmaz
dc.contributor.buuauthorDemir, Bilge Cetinkaya
dc.contributor.buuauthorOzan, Hakan
dc.contributor.buuauthorBaykara, Sema
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-9834-2021tr_TR
dc.contributor.scopusid36923039100tr_TR
dc.contributor.scopusid7003908072tr_TR
dc.contributor.scopusid54945413500tr_TR
dc.date.accessioned2023-06-05T09:44:46Z
dc.date.available2023-06-05T09:44:46Z
dc.date.issued2016-01-24
dc.description.abstractAimTo investigate the expression of Wilms' tumor 1 (WT1) protein in endometrial adenocarcinoma (EC) and endometrial intra-epithelial neoplasia (EIN). MethodsWT1 protein expression was determined on immunohistochemistry in 30 EC patients and in 20 EIN patients. WT1 protein expression in proliferative (n = 7), secretory (n = 9) and atrophic endometrium (n = 9) and benign endometrial polyps (n = 28) was used as the control group. Cellular and vascular WT1 staining was scored semiquantitatively. ResultsCellular WT1 staining was 67% and vascular positivity was 73% in the EC group. In the EIN group the cellular staining was 100% and vascular staining was 85%. Although all EIN samples were positive for cellular WT1 staining, median cellular staining score was similar to that of EC (median, 2; range, 1-3; IQR, 1.75 vs 2, 0-3, 0.75, respectively). Increasing EC grade and stage were not associated with cellular or vascular WT1 staining score. ConclusionWT1 is expressed in EIN.en_US
dc.identifier.citationAtik, Y. vd. (2016). "Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia". Journal of Obstetrics and Gynaecology Research, 42(7), 870-875.en_US
dc.identifier.endpage875tr_TR
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue7tr_TR
dc.identifier.pubmed27062662tr_TR
dc.identifier.scopus2-s2.0-84977107141tr_TR
dc.identifier.startpage870tr_TR
dc.identifier.urihttps://doi.org/10.1111/jog.12981
dc.identifier.urihttps://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.12981
dc.identifier.urihttp://hdl.handle.net/11452/32914
dc.identifier.volume42tr_TR
dc.identifier.wos000379847300017
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstetrics & gynecologyen_US
dc.subjectEndometrial adenocarcinomaen_US
dc.subjectEndometrial intra-epithelial neoplasiaen_US
dc.subjectWilms' tumor 1 proteinen_US
dc.subjectGene WT1en_US
dc.subjectImmunohistochemical detectionen_US
dc.subjectCell-proliferationen_US
dc.subjectCarcinomasen_US
dc.subjectCanceren_US
dc.subjectLeukemiaen_US
dc.subjectOvarianen_US
dc.subjectImmunotherapyen_US
dc.subjectP53en_US
dc.subject.emtreeWT1 proteinen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeCancer gradingen_US
dc.subject.emtreeCancer stagingen_US
dc.subject.emtreeCellular distributionen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeComorbidityen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDiabetes mellitusen_US
dc.subject.emtreeEndometrial diseaseen_US
dc.subject.emtreeEndometrium atrophyen_US
dc.subject.emtreeEndometrium carcinomaen_US
dc.subject.emtreeEndometrium polypen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePostmenopauseen_US
dc.subject.emtreePrevalenceen_US
dc.subject.emtreeProliferative endometriumen_US
dc.subject.emtreeProtein determinationen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeProtein localizationen_US
dc.subject.emtreeRetrospective studyen_US
dc.subject.emtreeSecretory endometriumen_US
dc.subject.emtreeUterine cervix carcinoma in situen_US
dc.subject.scopusAcute Myeloid Leukemia; Nephroblastoma; Denys-Drash Syndromeen_US
dc.subject.wosObstetrics & gynecologyen_US
dc.titleWilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasiaen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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