Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy
dc.contributor.author | Altay, Canan | |
dc.contributor.author | Seçil, Mustafa | |
dc.contributor.author | Demir, Tevfik | |
dc.contributor.author | Atik, Tahir | |
dc.contributor.author | Akıncı, Gülçin | |
dc.contributor.author | Kutbay, Nilüfer Özdemir | |
dc.contributor.author | Temeloğlu, Ela Keskin | |
dc.contributor.author | Şimşir, Ilgin Yıldırım | |
dc.contributor.author | Özışık, Seçil | |
dc.contributor.author | Demir, Leyla | |
dc.contributor.author | Tuna, Emine Burçin | |
dc.contributor.author | Aytaç, Hasibe | |
dc.contributor.author | Onay, Hüseyin | |
dc.contributor.author | Akıncı, Barış | |
dc.contributor.buuauthor | Eren, Erdal | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Endokrinoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-1684-1053 | tr_TR |
dc.contributor.researcherid | AAM-1734-2020 | tr_TR |
dc.contributor.researcherid | AAH-1155-2021 | tr_TR |
dc.contributor.scopusid | 36113153400 | tr_TR |
dc.date.accessioned | 2023-01-12T08:53:49Z | |
dc.date.available | 2023-01-12T08:53:49Z | |
dc.date.issued | 2017-05-29 | |
dc.description.abstract | PURPOSE We aimed to investigate residual adipose tissue with whole-body magnetic resonance imaging to differentiate between subtypes of lipodystrophy. METHODS A total of 32 patients 12 with congenital generalized lipodystrophy [CGL], 1 with acquired generalized lipodystrophy [AGL], 12 with familial partial lipodystrophy [FPLD], and 7 with acquired partial lipodystrophy [APL]) were included. RESULTS Despite generalized loss of metabolically active adipose tissue, patients with CGL1 caused by AGPAT2 mutations had a significant amount of residual adipose tissue in the scalp, earlobes, retro-orbital region, and palms and soles. No residual adipose tissue was noted particularly in the head and neck, palms and soles in CGL2 caused by BSCL2 mutations. CGL4 caused by mutations in the PTRF gene was characterized with well-preserved retro-orbital and bone marrow fat in the absence of any visible residual adipose tissue in other areas. No residual adipose tissue was observed in AGL. Despite loss of subcutaneous fat, periarticular adipose tissue was preserved in the lower limbs of patients with FPLD. Retro-orbital adipose tissue was surprisingly preserved in APL, although they lacked head and neck fat. CONCLUSION Lipodystrophies are a heterogeneous group of disorders characterized by generalized or partial loss of adipose tissue, which can be congenital or acquired. Our results suggest that residual adipose tissue characteristics can help distinguish different subtypes of lipodystrophy. | en_US |
dc.identifier.citation | Altay, C. vd. (2017). ''Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy''. Diagnostic and Interventional Radiology, 23(6), 428-434. | tr_TR |
dc.identifier.endpage | 434 | tr_TR |
dc.identifier.issn | 1305-3612 | |
dc.identifier.issue | 6 | tr_TR |
dc.identifier.pubmed | 29044029 | tr_TR |
dc.identifier.scopus | 2-s2.0-85032956287 | tr_TR |
dc.identifier.startpage | 428 | tr_TR |
dc.identifier.uri | https://doi.org/10.5152/dir.2017.17019 | |
dc.identifier.uri | https://www.dirjournal.org/en/determining-residual-adipose-tissue-characteristics-with-mri-in-patients-with-various-subtypes-of-lipodystrophy-131769 | |
dc.identifier.uri | http://hdl.handle.net/11452/30424 | |
dc.identifier.volume | 23 | tr_TR |
dc.identifier.wos | 000414273500004 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.trdizin | TrDizin | tr_TR |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Türk Radyoloji Derneği | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | Diagnostic and Interventional Radiology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Radiology, nuclear medicine & medical imaging | en_US |
dc.subject | Congenital generalized lipodystrophy | en_US |
dc.subject | Familial partial lipodystrophy | en_US |
dc.subject | Severe insulin-resistance | en_US |
dc.subject | Body-fat distribution | en_US |
dc.subject | Gene-expression | en_US |
dc.subject | Regional differences | en_US |
dc.subject | Ptrf mutationsi | en_US |
dc.subject | Identification | en_US |
dc.subject | Heterogeneity | en_US |
dc.subject | Deficiency | en_US |
dc.subject.emtree | Caveolin 1 | en_US |
dc.subject.emtree | Creatinine | en_US |
dc.subject.emtree | Low density lipoprotein cholesterol | en_US |
dc.subject.emtree | Adipose tissue | en_US |
dc.subject.emtree | Adolescent | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | AGPAT2 gene | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Child | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Congenital generalized lipodystrophy | en_US |
dc.subject.emtree | Enzyme linked immunosorbent assay | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Foot ulcer | en_US |
dc.subject.emtree | Gene | en_US |
dc.subject.emtree | Genetic screening | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Insulin sensitivity | en_US |
dc.subject.emtree | Lipodystrophy | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nuclear magnetic resonance imaging | en_US |
dc.subject.emtree | PTRF gene | en_US |
dc.subject.emtree | Differential diagnosis | en_US |
dc.subject.emtree | Lipodystrophy | en_US |
dc.subject.emtree | Middle aged | en_US |
dc.subject.emtree | Procedures | en_US |
dc.subject.emtree | Whole body imaging | en_US |
dc.subject.emtree | Young adult | en_US |
dc.subject.emtree | Total cholesterol level | en_US |
dc.subject.emtree | Diagnostic imaging | en_US |
dc.subject.mesh | Adipose tissue | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Diagnosis, differential | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Lipodystrophy | en_US |
dc.subject.mesh | Magnetic resonance imaging | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Whole body Imaging | en_US |
dc.subject.mesh | Young adult | en_US |
dc.subject.scopus | Congenital Generalized Lipodystrophy; Metreleptin; Acquired Partial Lipodystrophy | en_US |
dc.subject.wos | Radiology, nuclear medicine & medical imaging | en_US |
dc.title | Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy | en_US |
dc.type | Article |