Neuronal protective effects of focal ischemic pre-and/or postconditioning on the model of transient focal cerebral ischemia in rats
dc.contributor.author | Türeyen, Kudret | |
dc.contributor.buuauthor | Taşkapılıoğlu, Mevlüt Özgür | |
dc.contributor.buuauthor | Alkan, Tülin | |
dc.contributor.buuauthor | Gören, Bülent | |
dc.contributor.buuauthor | Şahin, Söner | |
dc.contributor.buuauthor | Taşkapılıoğlu, Özlem | |
dc.contributor.buuauthor | Korfalı, Ender | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Beyin ve Sinir Cerrahisi Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0001-5472-9065 | tr_TR |
dc.contributor.researcherid | AAH-1718-2021 | tr_TR |
dc.contributor.researcherid | ABB-8161-2020 | tr_TR |
dc.contributor.researcherid | AAH-1792-2021 | tr_TR |
dc.contributor.researcherid | AAW-5254-2020 | tr_TR |
dc.contributor.researcherid | AAK-6623-2020 | tr_TR |
dc.contributor.scopusid | 25936798300 | tr_TR |
dc.contributor.scopusid | 6601953747 | tr_TR |
dc.contributor.scopusid | 6602543716 | tr_TR |
dc.contributor.scopusid | 8272141000 | tr_TR |
dc.contributor.scopusid | 23037226400 | tr_TR |
dc.contributor.scopusid | 7004641343 | tr_TR |
dc.date.accessioned | 2021-12-06T08:35:10Z | |
dc.date.available | 2021-12-06T08:35:10Z | |
dc.date.issued | 2009-05 | |
dc.description.abstract | We investigated the neuroprotective effects of pre-and postconditioning on infarct volume in the transient middle cerebral artery occlusion (MCAo) model in rats. Thirty-two male rats were divided into occlusion, preconditioning, postconditioning and both pre- and postconditioning groups. MCAo (120 minutes) was monitored with continuous cerebral tissue oxygen (O-2) pressure (PtiO(2)). Pre-conditioning comprised 10 minutes of MC-Ao, 24 hours prior to the 120 minute MCAo. The postconditioning algorithm was 30 seconds of reperfusion followed by 30 seconds of MCAo. This cycle was repeated 3 times at the onset of reperfusion. Comparison of infarct volumes showed a significant difference between the conditioned groups and occlusion group. Although there was better protection in the preconditioning group compared with the other two conditioned groups, the results did not reach statistically significant levels. The results suggest that preconditioning, postconditioning and pre/post conditioning have protective effects on cerebral ischemia. | en_US |
dc.identifier.citation | Taşkapılıoğlu, M. Ö. vd. (2009). "Neuronal protective effects of focal ischemic pre-and/or postconditioning on the model of transient focal cerebral ischemia in rats". Journal of Clinical Neuroscience, 16(5), 693-697. | en_US |
dc.identifier.endpage | 697 | tr_TR |
dc.identifier.issn | 0967-5868 | |
dc.identifier.issn | 1532-2653 | |
dc.identifier.issue | 5 | tr_TR |
dc.identifier.pubmed | 19268597 | tr_TR |
dc.identifier.scopus | 2-s2.0-62549129011 | tr_TR |
dc.identifier.startpage | 693 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.jocn.2008.07.077 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0967586808004190 | |
dc.identifier.uri | http://hdl.handle.net/11452/23001 | |
dc.identifier.volume | 16 | tr_TR |
dc.identifier.wos | 000265223900019 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | Journal of Clinical Neuroscience | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Focal cerebral ischemia | en_US |
dc.subject | Neuroprotection | en_US |
dc.subject | Postconditioning | en_US |
dc.subject | Preconditioning | en_US |
dc.subject | Progenitor-cell proliferation | en_US |
dc.subject | Triphenyltetrazolium chloride | en_US |
dc.subject | Tolerance acquisition | en_US |
dc.subject | Artery occlusion | en_US |
dc.subject | Brain | en_US |
dc.subject | Identification | en_US |
dc.subject | Reperfusion | en_US |
dc.subject | Hypoxia | en_US |
dc.subject | Oxygen | en_US |
dc.subject | Genes | en_US |
dc.subject | Neurosciences & neurology | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Brain infarction size | en_US |
dc.subject.emtree | Brain ischemia | en_US |
dc.subject.emtree | Brain oxygen tension | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Ischemic preconditioning | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Neuroprotection | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Middle cerebral artery occlusion | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cerebrovascular circulation | en_US |
dc.subject.mesh | Disease models, animal | en_US |
dc.subject.mesh | Infarction, middle cerebral artery | en_US |
dc.subject.mesh | Ischemic preconditioning | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Neurologic examination | en_US |
dc.subject.mesh | Oxygen | en_US |
dc.subject.mesh | Pressure | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, sprague-dawley | en_US |
dc.subject.mesh | Reperfusion | en_US |
dc.subject.mesh | Reperfusion injury | en_US |
dc.subject.mesh | Statistics, nonparametric | en_US |
dc.subject.mesh | Time factors | en_US |
dc.subject.scopus | Ischemic Postconditioning; Reperfusion Injury; Mitochondrial Permeability Transition Pore | en_US |
dc.subject.wos | Clinical neurology | en_US |
dc.subject.wos | Neurosciences | en_US |
dc.title | Neuronal protective effects of focal ischemic pre-and/or postconditioning on the model of transient focal cerebral ischemia in rats | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 (Clinical neurology) | en_US |
dc.wos.quartile | Q4 (Neurosciences) | en_US |