Akut bronşiolitli çocuklarda human paraoksonaz-1 aktivitesi
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Dosyalar
Tarih
2020-08-21
Kurum Yazarları
Erenberk, Ufuk
Kahraman, Feyza Ustabaş
Özkaya, Emin
Nursoy, Mustafa Atilla
Demir, Ayşegül Doğan
Türel, Özden
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
Bursa Uludağ Üniversitesi
Özet
Human paraoksonaz-1 (PON1), oksidatif strese karşı çalışan endojen antioksidan moleküllerden biridir. Bu çalışmada akut bronşiolitli çocuklarda serum PON1 aktivitesini araştırmayı amaçladık. Akut bronşiyolitli 3-21 aylık 29 çocuk ile yaş uyumlu 35 sağlıklı kontrol çalışmaya dahil edildi. Bronşiolit hastaları hafif (% 65) ve orta (% 35) olarak sınıflandırıldı. Akut bronşiolitli hastalar ile kontrol grubu arasında PON1'in paraoksonaz ve arilesteraz aktiviteleri karşılaştırıldı. Akut bronşiyolitli çocukların paraoksonaz aktivitesi sağlıklı kontrollere göre daha düşüktü, ancak fark anlamlı değildi (127.53 ± 64.17 U / L'ye karşı 153.95 ± 74.40 U / L) (p = 0.13). Hafif ve orta derecede bronşiyolitli çocuklarda arilesteraz aktivitesi kontrol grubuna göre anlamlı olarak daha azdı (142.43 ± 56.60 kU / L ve 103.05 ± 26.03 kU / L'ye karşılık 201.09 ± 57.26 kU / L) (p <0.001). Akut bronşiolitli çocuklarda serum PON1 aktivitesi kontrol grubuna göre daha düşüktü. Antioksidan kapasitenin arttırılması, viral kaynaklı akciğer hastalığında etkili bir tedavi aracı olabilir.
Human paraoxonase-1 (PON1) is one of the endogenous antioxidant molecules working against oxidative stress. We aimed to investigate serum PON1 activity in children with acute bronchiolitis. A total of 29 children aged between 3-21 months with acute bronchiolitis and 35 age-matched healthy controls were included in the study. Bronchiolitis patients were further classified as mild (65%) and moderate (35%). Paraoxonase and arylesterase activities of PON1 were compared between patients with acute bronchiolitis and the control group. Paraoxonase activity of children with acute bronchiolitis was lower than healthy controls but the difference was not significant (127.53 ± 64.17 U/L versus 153.95 ± 74.40 U/L) (p=0.13). Arylesterase activity was significantly decreased in children with mild and moderate bronchiolitis in comparison to the control group (142.43± 56.60 kU/L and 103.70± 26.03 kU/L versus 201.09± 57.26 kU/L) (p<0.001). Serum PON1 activity was lower in children with acute bronchiolitis compared to controls. Increasing antioxidant capacity may be an effective means of therapy in viral induced lung disease.
Human paraoxonase-1 (PON1) is one of the endogenous antioxidant molecules working against oxidative stress. We aimed to investigate serum PON1 activity in children with acute bronchiolitis. A total of 29 children aged between 3-21 months with acute bronchiolitis and 35 age-matched healthy controls were included in the study. Bronchiolitis patients were further classified as mild (65%) and moderate (35%). Paraoxonase and arylesterase activities of PON1 were compared between patients with acute bronchiolitis and the control group. Paraoxonase activity of children with acute bronchiolitis was lower than healthy controls but the difference was not significant (127.53 ± 64.17 U/L versus 153.95 ± 74.40 U/L) (p=0.13). Arylesterase activity was significantly decreased in children with mild and moderate bronchiolitis in comparison to the control group (142.43± 56.60 kU/L and 103.70± 26.03 kU/L versus 201.09± 57.26 kU/L) (p<0.001). Serum PON1 activity was lower in children with acute bronchiolitis compared to controls. Increasing antioxidant capacity may be an effective means of therapy in viral induced lung disease.
Açıklama
Anahtar kelimeler
Paraoksonaz, Paraoxonase, Arilesteraz, Arylesterase, Oxidative stress, Bronchiolitis, Oksidatif stres, Bronşiolit, Çocuk, Arylesterase, Oxidative stress, Bronchiolitis, Child
Alıntı
Erenberk, U. vd. (2020). "Akut bronşiolitli çocuklarda human paraoksonaz-1 aktivitesi". Bursa Uludağ Üniversitesi Güncel Pediatri, 18(3), 336-345.