Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus)

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dc.contributor.buuauthorDere, Egemen
dc.contributor.buuauthorArı, Ferda Özdikicioğlu
dc.contributor.buuauthorTosunoğlu, Hakan
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.orcid0000-0002-6729-7908tr_TR
dc.contributor.researcheridAAH-5068-2021tr_TR
dc.contributor.researcheridAAG-7012-2021tr_TR
dc.contributor.scopusid6603627015tr_TR
dc.contributor.scopusid6504081459tr_TR
dc.contributor.scopusid23478447500tr_TR
dc.date.accessioned2022-10-31T07:31:15Z
dc.date.available2022-10-31T07:31:15Z
dc.date.issued2007
dc.description.abstractIn this study we investigated the hepatotoxic effect of DNOC in rats, using biochemical serum parameters as indicators of liver disease. Experimental groups were injected intraperitoneally with 2.8 mg/kg DNOC. While an increase was determined in LDH activities for all periods, an increase was determined for urea values only up to 16 hours. In general, increased AST and ALP activities were recorded up to the 8(th) hour. Thereof, at later periods inhibition was observed. Inhibition was observed in female rats, while ALT activation was observed in male rats. Amylase activity inhibition was observed in both groups. Increased values were observed for cholesterol and HDL at the initial hours. No significant changes were observed in triglyceride levels. As a result, it has been observed that DNOC caused changes in serum enzyme activities and in biochemical parameters in female and male rats.en_US
dc.identifier.citationDere, E. vd. (2007). "Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus)". Acta Veterinaria-Beograd, 57(5-6), 497-507.en_US
dc.identifier.endpage507tr_TR
dc.identifier.issn0567-8315
dc.identifier.issn1820-7448
dc.identifier.issue5-6tr_TR
dc.identifier.scopus2-s2.0-38549130149tr_TR
dc.identifier.startpage497tr_TR
dc.identifier.urihttp://www.doiserbia.nb.rs/img/doi/0567-8315/2007/0567-83150706497D.pdf
dc.identifier.urihttps://doi.org/10.2298/AVB0706497D
dc.identifier.urihttp://hdl.handle.net/11452/29267
dc.identifier.volume57tr_TR
dc.identifier.wos000251981100011
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.journalActa Veterinaria-Beograden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectALPen_US
dc.subjectRattusen_US
dc.subjectRattus norvegicusen_US
dc.subjectALTen_US
dc.subjectASTen_US
dc.subjectDNOCen_US
dc.subjectLDHen_US
dc.subjectRaten_US
dc.subjectVeterinary sciencesen_US
dc.subjectCyprinus-carpio L.en_US
dc.subjectLiveren_US
dc.subjectPesticidesen_US
dc.subjectExposureen_US
dc.subjectBenzeneen_US
dc.subjectEnzymesen_US
dc.subjectTissuesen_US
dc.subject.scopusHeptachlor; Persistent Organic Pollutants; Photocatalytic Activityen_US
dc.subject.wosVeterinary sciencesen_US
dc.titleHepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus)en_US
dc.typeArticle
dc.wos.quartileQ4en_US

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