Effect of low-dose irradiation on structural and mechanical properties of hyaline cartilage-like fibrocartilage
dc.contributor.author | Öncan, Tevfik | |
dc.contributor.author | Ermutlu, Cenk | |
dc.contributor.buuauthor | Demrag, Burak | |
dc.contributor.buuauthor | Yalçınkaya, Ulviye | |
dc.contributor.buuauthor | Özkan, Lütfü | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi ve Travmatoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı. | tr_TR |
dc.contributor.researcherid | AAH-8924-2021 | tr_TR |
dc.contributor.researcherid | EVT-6166-2022 | |
dc.contributor.researcherid | JLK-0331-2023 | |
dc.contributor.scopusid | 55801460800 | tr_TR |
dc.contributor.scopusid | 6508300295 | tr_TR |
dc.contributor.scopusid | 55915679500 | tr_TR |
dc.date.accessioned | 2024-03-25T07:29:24Z | |
dc.date.available | 2024-03-25T07:29:24Z | |
dc.date.issued | 2013 | |
dc.description.abstract | Objective: The aim of this study was to analyze the effect of low-dose irradiation on fibrous cartilage and to obtain a hyaline cartilage-like fibrocartilage (HCLF) with similar structural and mechanical properties to hyaline cartilage.Methods: An osteochondral defect was created in 40 knees of 20 rabbits. At the 7th postoperative day, a single knee of each rabbit was irradiated with a total dose of 5.0 Gy in 1.0 Gy fractions for 5 days (radiotherapy group), while the other knee was not irradiated (control group). Rabbits were then divided into four groups of 5 rabbits each. The first three groups were sacrificed at the 4th, 8th and the 12th postoperative weeks and cartilage defects were macroscopically and microscopically evaluated. The remaining group of 5 rabbits was sacrificed at the 12th week and biomechanical compression tests were performed on the cartilage defects.Results: There was no significant biomechanical difference between the radiotherapy and the control group (p=0.686). There was no significant macroscopic and microscopic difference between groups (p=0.300). Chondrocyte clustering was observed in the irradiated group.Conclusion: Low-dose irradiation does not affect the mechanical properties of HCLF in vivo. However, structural changes such as chondrocyte clustering were observed. | en_US |
dc.identifier.citation | Öncan, T. vd. (2013). “Effect of low-dose irradiation on structural and mechanical properties of hyaline cartilage-like fibrocartilage”. Acta Orthopaedica et Traumatologica Turcica, 47(2), 127-133. | en_US |
dc.identifier.doi | https://doi.org/10.3944/AOTT.2013.2709 | en_US |
dc.identifier.endpage | 133 | tr_TR |
dc.identifier.issn | 1017-995X | |
dc.identifier.issue | 2 | tr_TR |
dc.identifier.pubmed | 23619547 | tr_TR |
dc.identifier.scopus | 2-s2.0-84880604577 | tr_TR |
dc.identifier.startpage | 127 | tr_TR |
dc.identifier.uri | https://www.aott.org.tr/en/effect-of-lowdose-irradiation-on-structural-and-mechanical-properties-of-hyaline-cartilagelike-fibrocartilage-134136 | en_US |
dc.identifier.uri | https://hdl.handle.net/11452/40605 | en_US |
dc.identifier.volume | 47 | tr_TR |
dc.identifier.wos | 000319232100011 | tr_TR |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Turkish Assoc Orthopaedics Traumatology | en_US |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | Acta Orthopaedica et Traumatologica Turcica | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Orthopedics | en_US |
dc.subject | Hyaline cartilage | en_US |
dc.subject | Hyaline cartilage-like fibrocartilage | en_US |
dc.subject | Low-dose irradiation | en_US |
dc.subject | Mechanical | en_US |
dc.subject | Structural | en_US |
dc.subject | Full-thickness defects | en_US |
dc.subject | Adjuvant-induced arthritis | en_US |
dc.subject | Autogenous periosteal grafts | en_US |
dc.subject | Continuous passive motion | en_US |
dc.subject | Rabbit knee-joint | en_US |
dc.subject | Articular-cartilage | en_US |
dc.subject | Radiation-therapy | en_US |
dc.subject | Osteochondral defects | en_US |
dc.subject | Benign diseases | en_US |
dc.subject | Repair | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Articular cartilage | en_US |
dc.subject.emtree | Biomechanics | en_US |
dc.subject.emtree | Cell differentiation | en_US |
dc.subject.emtree | Cytology | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Fibrocartilage | en_US |
dc.subject.emtree | Knee | en_US |
dc.subject.emtree | Pathology | en_US |
dc.subject.emtree | Physiology | en_US |
dc.subject.emtree | Rabbit | en_US |
dc.subject.emtree | Radiation dose | en_US |
dc.subject.emtree | Radiation exposure | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biomechanics | en_US |
dc.subject.mesh | Cartilage, articular | en_US |
dc.subject.mesh | Cell differentiation | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fibrocartilage | en_US |
dc.subject.mesh | Knee joint | en_US |
dc.subject.mesh | Rabbits | en_US |
dc.subject.mesh | Radiation dosage | en_US |
dc.subject.scopus | Articular Cartilage; Chondrocytes; Cartilage | en_US |
dc.subject.wos | Orthopedics | en_US |
dc.title | Effect of low-dose irradiation on structural and mechanical properties of hyaline cartilage-like fibrocartilage | en_US |
dc.type | Article | en_US |
dc.wos.quartile | Q4 (Orthopedics) | en_US |
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