Clinical significance of activity ALT enzyme in patients with hepatitis C virus
dc.contributor.buuauthor | Akkaya, Önder | |
dc.contributor.buuauthor | Kıyıcı, Murat | |
dc.contributor.buuauthor | Yılmaz, Yusuf | |
dc.contributor.buuauthor | Ulukaya, Engin | |
dc.contributor.buuauthor | Yerci, Ömer | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0003-4518-5283 | tr_TR |
dc.contributor.orcid | 0000-0002-3208-6211 | tr_TR |
dc.contributor.researcherid | K-5792-2018 | tr_TR |
dc.contributor.researcherid | K-6651-2012 | tr_TR |
dc.contributor.researcherid | AAI-4213-2021 | tr_TR |
dc.contributor.scopusid | 22933763300 | tr_TR |
dc.contributor.scopusid | 6507627491 | tr_TR |
dc.contributor.scopusid | 22936014300 | tr_TR |
dc.contributor.scopusid | 6602927353 | tr_TR |
dc.contributor.scopusid | 6603810549 | tr_TR |
dc.date.accessioned | 2022-09-14T12:24:20Z | |
dc.date.available | 2022-09-14T12:24:20Z | |
dc.date.issued | 2007-11-07 | |
dc.description.abstract | Aim: To investigate serum alanine aminotransferase (ALT) levels in relation to the clinical, biochemical, ultrasonographic and histological characteristics of patients with hepatitis C virus. Methods: Duration of disease, HCV-RNA, liver steatosis, and the hepatitis activity index (HAI) were correlated with serum ALT in 36 patients with HCV. ALT values were also investigated in 16 control subjects without any liver diseases. Results: In bivariate analyses, ALT levels correlated with duration of HCV infection (P < 0.01), HCV-RNA (P < 0.05), and the HAI (P < 0.01). Among the components of the HAI, ALT concentrations were significantly associated with periportal bridging/necrosis (P < 0.01) and fibrosis (P < 0.05). In multivariate analysis, periportal bridging/necrosis (β = 0.508; P < 0.01), duration of HCV infection (β = 0.413; P < 0.01), and HCV-RNA (β = 0.253; P < 0.05) were independently associated with ALT activity. The normal ALT activity for men and women was < 23 IU/L and < 22 IU/L, respectively. Conclusion: In patients with HCV, alterations in the liver tissue as reflected by ALT elevation are mainly associated with periportal bridging/necrosis, viral load and duration of disease. A cut-off value < 23 IU/L distinguished with high diagnostic accuracy healthy controls from patients with HCV. | en_US |
dc.identifier.citation | Akkaya, O. vd. (2007). "Clinical significance of activity ALT enzyme in patients with hepatitis C virus". World Journal of Gastroenterology, 13(41), 5481-5485. | en_US |
dc.identifier.endpage | 5485 | tr_TR |
dc.identifier.issn | 1007-9327 | |
dc.identifier.issue | 41 | tr_TR |
dc.identifier.pubmed | 17907292 | tr_TR |
dc.identifier.scopus | 2-s2.0-35348946339 | tr_TR |
dc.identifier.startpage | 5481 | tr_TR |
dc.identifier.uri | https://doi.org/10.3748/wjg.v13.i41.5481 | |
dc.identifier.uri | https://www.wjgnet.com/1007-9327/full/v13/i41/5481.htm | |
dc.identifier.uri | 2219-2840 | |
dc.identifier.uri | http://hdl.handle.net/11452/28724 | |
dc.identifier.volume | 13 | tr_TR |
dc.identifier.wos | 000249901500009 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Baishideng Publishing Group | en_US |
dc.relation.journal | World Journal of Gastroenterology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Viral load | en_US |
dc.subject | Disease duration | en_US |
dc.subject | Hepatitis C virus | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Normal alanine aminotransferase | en_US |
dc.subject.emtree | Diagnostic accuracy | en_US |
dc.subject.emtree | Alanine aminotransferase | en_US |
dc.subject.emtree | Virus RNA | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Alanine aminotransferase blood level | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Bivariate analysis | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Correlation analysis | en_US |
dc.subject.emtree | Enzyme activity | en_US |
dc.subject.emtree | Sensitivity and specificity | en_US |
dc.subject.emtree | Diagnostic value | en_US |
dc.subject.emtree | Disease activity | en_US |
dc.subject.emtree | Disease duration | en_US |
dc.subject.emtree | Echography | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Fatty liver | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Hepatitis C | en_US |
dc.subject.emtree | Hepatitis C virus | en_US |
dc.subject.emtree | Histopathology | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Human tissue | en_US |
dc.subject.emtree | Liver fibrosis | en_US |
dc.subject.emtree | Liver necrosis | en_US |
dc.subject.emtree | Roc curve | en_US |
dc.subject.emtree | Multivariate analysis | en_US |
dc.subject.emtree | Sex difference | en_US |
dc.subject.emtree | Statistical significance | en_US |
dc.subject.emtree | Virus load | en_US |
dc.subject.scopus | Alanine Aminotransferase; Chronic Hepatitis C; Liver Fibrosis | en_US |
dc.subject.wos | Gastroenterology & hepatology | en_US |
dc.title | Clinical significance of activity ALT enzyme in patients with hepatitis C virus | en_US |
dc.type | Article |