Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey

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dc.contributor.authorÖzbek, Uǧur
dc.contributor.authorSırma, Sema
dc.contributor.authorAğaoğlu, Leyla
dc.contributor.authorYüksel, Lebriz
dc.contributor.authorAnak, Sema
dc.contributor.authorYıldız, İnci
dc.contributor.authorDevecioğlu, Omer
dc.contributor.authorTimur, Çetin
dc.contributor.authorGedikoğlu, Gündüz
dc.contributor.buuauthorMeral, Adalet
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-1201-7542tr_TR
dc.contributor.orcid0000-0001-5319-0547tr_TR
dc.contributor.researcheridU-6138-2017tr_TR
dc.contributor.researcheridC-9513-2017tr_TR
dc.contributor.scopusid6602571317tr_TR
dc.date.accessioned2023-03-24T09:45:08Z
dc.date.available2023-03-24T09:45:08Z
dc.date.issued2003-03
dc.description.abstractPurpose: The t(12;21) translocation is the most common reciprocal chromosomal rearrangement in pediatric acute lymphoblastic leukemia (ALL). This translocation fuses two genes, TEL and AML1, and results in the production of the TEL-AML1 fusion protein. The authors investigated the incidence and prognostic significance of the TEL-AML1 fusion gene in patients with ALL in Turkey. Methods: The authors analyzed 219 children with ALL using the reverse transcription-polymerase chain reaction. Results: The TEL-AML1 fusion transcript was detected in 20.1% (44/219) of newly diagnosed children with ALL. TEL-AML1-positive patients had precursor B-cell ALL and were 3 to 10 years old at diagnosis. TEL-AML1-positive patients had a significantly lower rate of relapse compared with TEL-AML1-negative patients. TEL-AML1-positive patients have a higher overall survival rate than TEL-AML1-negative patients. Conclusions: These data support that the presence of TEL-AML1 at diagnosis is an independent favorable prognostic indicator in patients with ALL in Turkey.en_US
dc.identifier.citationÖzbek, U. vd. (2003). “Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey”. Journal of Pediatric Hematology Oncology, 25(3), 204-208.en_US
dc.identifier.endpage208tr_TR
dc.identifier.issn1077-4114
dc.identifier.issue3tr_TR
dc.identifier.pubmed12621238tr_TR
dc.identifier.scopus2-s2.0-0037336142tr_TR
dc.identifier.startpage204tr_TR
dc.identifier.urihttps://doi.org/10.1097/00043426-200303000-00005
dc.identifier.urihttps://journals.lww.com/jpho-online/fulltext/2003/03000/prognostic_significance_of_the_tel_aml1_fusion.5.aspx
dc.identifier.urihttp://hdl.handle.net/11452/31731
dc.identifier.volume25tr_TR
dc.identifier.wos000181416800003tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Pediatric Hematology Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectHematologyen_US
dc.subjectPediatricsen_US
dc.subjectAcute lymphoblastic leukemiaen_US
dc.subjectPediatric leukemiaen_US
dc.subjectTEL-AML1en_US
dc.subjectTEL/AML1 fusionen_US
dc.subjectCryptic t(12-21)en_US
dc.subjectChildhooden_US
dc.subjectChildrenen_US
dc.subjectTranscripten_US
dc.subjectFrequencyen_US
dc.subjectSubgroupen_US
dc.subjectRelapseen_US
dc.subject.emtreeAcute lymphoblastic leukemiaen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer incidenceen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeChildhood leukemiaen_US
dc.subject.emtreeClinical featureen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFusion geneen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeImmunophenotypingen_US
dc.subject.emtreeKaplan meier methoden_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePre b lymphocyteen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeReciprocal chromosome translocationen_US
dc.subject.emtreeRelapseen_US
dc.subject.emtreeReverse transcription polymerase chain reactionen_US
dc.subject.emtreeSurvival rateen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeHybrid proteinen_US
dc.subject.emtreeTel aml1 proteinen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshCore binding factor alpha 2 subuniten_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, newbornen_US
dc.subject.meshLeukemia, lymphocytic, acuteen_US
dc.subject.meshMaleen_US
dc.subject.meshOncogene proteins, fusionen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSurvival rateen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusAcute Lymphoblastic Leukemia; Chromosome 21; Pre B Lymphocyteen_US
dc.subject.wosOncologyen_US
dc.subject.wosHematologyen_US
dc.subject.wosPediatricsen_US
dc.titlePrognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkeyen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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