Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

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dc.contributor.authorSudha, Thangirala
dc.contributor.authorBharali, Dhruba J.
dc.contributor.authorDarwish, Noureldien H. E.
dc.contributor.authorKeating, Kelly A.
dc.contributor.authorLin, Hung-Yun
dc.contributor.authorDavis, Paul J.
dc.contributor.authorMousa, Shaker A. Shaker A.
dc.contributor.buuauthorYalçın, Murat
dc.contributor.buuauthorCoşkun, Melis Debreli
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.researcheridAAF-3992-2020tr_TR
dc.contributor.scopusid57192959734tr_TR
dc.contributor.scopusid57193066146tr_TR
dc.date.accessioned2022-12-22T11:43:46Z
dc.date.available2022-12-22T11:43:46Z
dc.date.issued2017
dc.descriptionNanoPharmaceuticals LLC (Rensselaer, NY, USA)en_US
dc.description.abstractThe tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin alpha v beta 3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P < 0.001) and 2.3-fold (doxorubicin; P < 0.01) higher than with conventional systemic drug administration. Tumor volume reductions reflected enhanced xenograft drug uptake. Cell viability was estimated by bioluminescent signaling in pancreatic tumors and confirmed an increased paclitaxel effect with drug delivery by NDAT. NDAT delivery of chemotherapy increases drug delivery to cancers and increases drug efficacy.en_US
dc.identifier.citationSudha, T. vd. (2017). ''Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac''. International Journal of Nanomedicine, 12, 1305-1315.en_US
dc.identifier.endpage1315tr_TR
dc.identifier.issn1178-2013
dc.identifier.pubmed28243091tr_TR
dc.identifier.scopus2-s2.0-85013472911tr_TR
dc.identifier.startpage1305tr_TR
dc.identifier.urihttps://doi.org/10.2147/IJN.S123742
dc.identifier.urihttps://www.dovepress.com/targeted-delivery-of-paclitaxel-and-doxorubicin-to-cancer-xenografts-v-peer-reviewed-fulltext-article-IJN
dc.identifier.urihttp://hdl.handle.net/11452/30051
dc.identifier.volume12tr_TR
dc.identifier.wos000394048400002tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherDove Medicalen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalInternational Journal of Nanomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectScience & technology - other topicsen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectDoxorubicinen_US
dc.subjectIntegrinen_US
dc.subjectNanoparticleen_US
dc.subjectNanotetracen_US
dc.subjectNDATen_US
dc.subjectPaclitaxelen_US
dc.subjectTetraiodothyroacetic aciden_US
dc.subjectXenograftsen_US
dc.subjectActivated protein-kinaseen_US
dc.subjectTetraiodothyroacetic aciden_US
dc.subjectThyroid-hormoneen_US
dc.subjectIn-vitroen_US
dc.subjectCo-deliveryen_US
dc.subjectCellsen_US
dc.subjectNanomedicineen_US
dc.subjectReceptoren_US
dc.subjectGrowthen_US
dc.subjectCisplatinen_US
dc.subject.emtreeDiamino tetraiodothyroacetic acid nanoparticleen_US
dc.subject.emtreeDocetaxelen_US
dc.subject.emtreeDoxorubicinen_US
dc.subject.emtreeNanoparticleen_US
dc.subject.emtreePaclitaxelen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeDoxorubicinen_US
dc.subject.emtreeLactic aciden_US
dc.subject.emtreeNanoparticleen_US
dc.subject.emtreePaclitaxelen_US
dc.subject.emtreePolyglycolic aciden_US
dc.subject.emtreePolylactic acid-polyglycolic acid copolymeren_US
dc.subject.emtreeTetraiodothyroacetic aciden_US
dc.subject.emtreeThyroxineen_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeAntineoplastic activityen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBreast canceren_US
dc.subject.emtreeCell viabilityen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug adsorptionen_US
dc.subject.emtreeDrug delivery systemen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeDrug formulationen_US
dc.subject.emtreeDrug uptakeen_US
dc.subject.emtreeEx vivo studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeMouseen_US
dc.subject.emtreeNanoencapsulationen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePancreas canceren_US
dc.subject.emtreeParticle sizeen_US
dc.subject.emtreeTumor volumeen_US
dc.subject.emtreeAnalogs and derivativesen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBreast Neoplasmsen_US
dc.subject.emtreeCell survivalen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeDrug screeningen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeNude mouseen_US
dc.subject.emtreePancreatic Neoplasmsen_US
dc.subject.emtreePhoton correlation spectroscopyen_US
dc.subject.emtreeTumor cell lineen_US
dc.subject.emtreeIn vivo studyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic agentsen_US
dc.subject.meshBreast neoplasmsen_US
dc.subject.meshCell line, tumoren_US
dc.subject.meshCell survivalen_US
dc.subject.meshDoxorubicinen_US
dc.subject.meshDrug delivery systemsen_US
dc.subject.meshDynamic light scatteringen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLactic aciden_US
dc.subject.meshMice, nudeen_US
dc.subject.meshNanoparticlesen_US
dc.subject.meshPaclitaxelen_US
dc.subject.meshPancreatic neoplasmsen_US
dc.subject.meshParticle sizeen_US
dc.subject.meshPolyglycolic aciden_US
dc.subject.meshThyroxineen_US
dc.subject.meshXenograft model antitumor assaysen_US
dc.subject.scopusIntegrin; Thyroid Hormones; Nano-Diamino-Tetracen_US
dc.subject.wosNanoscience & nanotechnologyen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleTargeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetracen_US
dc.typeArticle
dc.wos.quartileQ2 (Nanoscience & nanotechnology)en_US
dc.wos.quartileQ1 (Pharmacology & pharmacy)en_US

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