The protective effect of ClinOleic against post-surgical adhesions
dc.contributor.buuauthor | Altınel, Yüksel | |
dc.contributor.buuauthor | Taşpınar, Ersoy | |
dc.contributor.buuauthor | Özgüç, Halil | |
dc.contributor.buuauthor | Öztürk, Ersin | |
dc.contributor.buuauthor | Ülker , Elif Akyıldız | |
dc.contributor.buuauthor | Baǧdaş, Deniz | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi. | tr_TR |
dc.contributor.researcherid | AAL-9231-2020 | tr_TR |
dc.contributor.scopusid | 26657125600 | tr_TR |
dc.contributor.scopusid | 55993367600 | tr_TR |
dc.contributor.scopusid | 6603867989 | tr_TR |
dc.contributor.scopusid | 35070171400 | tr_TR |
dc.contributor.scopusid | 8559530600 | tr_TR |
dc.contributor.scopusid | 15062425700 | tr_TR |
dc.date.accessioned | 2024-02-15T12:14:01Z | |
dc.date.available | 2024-02-15T12:14:01Z | |
dc.date.issued | 2014-01 | |
dc.description.abstract | BACKGROUND: Although the English-language literature is full of studies about post-surgical adhesions, no definitive method has yet been identified to prevent them. The goal of this study was to investigate the effect of ClinOleic on reducing post-surgical adhesion formation. METHODS: Surgery was performed on 40 adult female Sprague-Dawley rats that were randomly assigned to receive either intraperitoneal ClinOleic, which was used to mimic chyle (ClinOleic group), soybean oil (soybean oil group), olive oil (olive oil group), or 0.9% NaCl suspension (control group). All rats underwent laparotomy, side-wall and cecal abrasion, and primary closure. On the 30th day following surgery, rats were sacrificed and examined using the Majuzi adhesion classification and histopathological grading scales. RESULTS: The adhesion and histopathological scores of the ClinOleic group were significantly lower compared to the control group (0.9% NaCl) (p<0.05). A statistically significant decrease in fibrosis was observed in the soybean and olive oil groups when compared to the control group (p<0.05). However, the adhesion grades of the ClinOleic, soybean and olive oil groups were comparable. We did not observe any post-surgical adhesions in the ClinOleic group. CONCLUSION: The parenteral nutrition solution ClinOleic may be an effective and readily available agent for the prevention of post-surgical adhesions. | en_US |
dc.identifier.citation | Altınel, Y. vd. (2014). "The protective effect of ClinOleic against post-surgical adhesions". Ulusal Travma ve Acil Cerrahi Dergisi, 20(1), 1-6. | en_US |
dc.identifier.doi | https://doi.org/10.5505/tjtes.2014.12244 | en_US |
dc.identifier.endpage | 6 | tr_TR |
dc.identifier.issn | 1306-696X | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 24639307 | tr_TR |
dc.identifier.scopus | 2-s2.0-84891863122 | tr_TR |
dc.identifier.startpage | 1 | tr_TR |
dc.identifier.uri | http://jag.journalagent.com/travma/pdfs/UTD_20_1_1_6.pdf | en_US |
dc.identifier.uri | https://hdl.handle.net/11452/39782 | en_US |
dc.identifier.volume | 20 | tr_TR |
dc.identifier.wos | 000329901000001 | tr_TR |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Turkish Assoc Trauma Emergency Surgery | en_US |
dc.relation.journal | Ulusal Travma ve Acil Cerrahi Dergisi | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Abdominal surgery | en_US |
dc.subject | Intra-abdominal adhesions | en_US |
dc.subject | Adhesion prevention | en_US |
dc.subject | ClinOleic | en_US |
dc.subject | Olive oil | en_US |
dc.subject | Endothelial function | en_US |
dc.subject | Rat model | en_US |
dc.subject | Peritoneal adhesions | en_US |
dc.subject | Prevention | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Reduction | en_US |
dc.subject | Mesh | en_US |
dc.subject | Barrier | en_US |
dc.subject | Liquid | en_US |
dc.subject | Emergency medicine | en_US |
dc.subject.emtree | Abdominal surgery | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Artery intima proliferation | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Chyle | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Fibrosis | en_US |
dc.subject.emtree | Histopathology | en_US |
dc.subject.emtree | Inflammation | en_US |
dc.subject.emtree | Laparotomy | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Peritoneal cavity | en_US |
dc.subject.emtree | Postoperative care | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Tissue adhesion | en_US |
dc.subject.emtree | Tissue section | en_US |
dc.subject.emtree | Adverse effects | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Drug effects | en_US |
dc.subject.emtree | Pathology | en_US |
dc.subject.emtree | Peritoneum | en_US |
dc.subject.emtree | Procedures | en_US |
dc.subject.emtree | Randomization | en_US |
dc.subject.emtree | Sprague dawley rat | en_US |
dc.subject.emtree | Surgery | en_US |
dc.subject.emtree | Tissue adhesions | en_US |
dc.subject.emtree | Clinoleic | en_US |
dc.subject.emtree | Olive oil | en_US |
dc.subject.emtree | Seprafilm | en_US |
dc.subject.emtree | Soybean oil | en_US |
dc.subject.emtree | Spraygel | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Clinoleic | en_US |
dc.subject.emtree | Protective agent | en_US |
dc.subject.emtree | Soybean oil | en_US |
dc.subject.emtree | Vegetable oil | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Digestive system surgical procedures | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Laparotomy | en_US |
dc.subject.mesh | Peritoneum | en_US |
dc.subject.mesh | Plant oils | en_US |
dc.subject.mesh | Protective agents | en_US |
dc.subject.mesh | Random allocation | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, sprague-dawley | en_US |
dc.subject.mesh | Soybean oil | en_US |
dc.subject.mesh | Tissue adhesions | en_US |
dc.subject.scopus | Adhesion; Tissue Adhesions; Icodextrin | en_US |
dc.subject.wos | Emergency medicine | en_US |
dc.title | The protective effect of ClinOleic against post-surgical adhesions | en_US |
dc.title.alternative | Cerrahi sonrasi{dotless} oluşan kari{dotless}niçi yapi{dotless}şi{dotless}kli{dotless}klara karşi{dotless} ClinOleic'in koruyucu etkinliǧi | tr_TR |
dc.type | Article | en_US |
dc.wos.quartile | Q4 (Emergency Medicine) | en_US |