Aspirin resistance and oxidative stress in patients with coronary artery disease
dc.contributor.buuauthor | Serdar, Zehra | |
dc.contributor.buuauthor | Doǧruk, Elif Emre | |
dc.contributor.buuauthor | Serdar, Akın | |
dc.contributor.buuauthor | Günay, Şeyda | |
dc.contributor.buuauthor | Karagöz, İsminur Şaka | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-0909-618X | tr_TR |
dc.contributor.orcid | 0000-0003-0012-345X | tr_TR |
dc.contributor.researcherid | AAH-6200-2021 | tr_TR |
dc.contributor.researcherid | AAI-5350-2021 | tr_TR |
dc.contributor.scopusid | 57222002284 | tr_TR |
dc.contributor.scopusid | 55355828300 | tr_TR |
dc.contributor.scopusid | 6603403111 | tr_TR |
dc.contributor.scopusid | 55988316300 | tr_TR |
dc.contributor.scopusid | 55988628600 | tr_TR |
dc.date.accessioned | 2023-05-08T08:18:36Z | |
dc.date.available | 2023-05-08T08:18:36Z | |
dc.date.issued | 2013-09 | |
dc.description.abstract | Objective: To examine the relationship between aspirin resistance and oxidative stress in patients with coronary artery disease. Material and Method: A total of 100 patients (35 females, 65 males) with coronary arteiy disease were enrolled in the study. Platelet function was evaluated by a Multiple Platelet Function Analyzer according to impedance aggregomeby method. Agregation Unite (AU) with a >706 AU*min despite regular aspirin therapy, was defined as Aspirin resistance. and aspirin semiresponders were defined as a 300-706 AU*min. Aspirin-sensitive patients were defined as a <300 AU*min. While serum malondialdehyde (MDA) and vitamin E concentrations were determined by the high-performance liquid chromatography, other oxidant and antioxidant parameters were measured spectrophotornetrically. Results: Of the patients studied, 7% were aspirin resistant, 15% were aspirin semiresponders and 78% were aspirin sensitive. While serum MDA, protein carbonyls and total sialic acid concentrations were significantly increased, serum antioxidant vitamins (vitamin E and total carotene) and enzymes (paraoxonase, arylesterase and catalase) were significantly decreased in patients with aspirin resistance. We found strong positive correlations (p<0.001) between aspirin resistance and oxidant parameters and weak negative correlations (p<0.05) between aspirin resistance and antioxidant vitamins and enzymes. Conclusion: Aspirin resistance is related to oxidant and antioxidant parameters in patients with coronary artery disease. However, there is still need for further studies to better elucidate the relationship between aspirin resistance and oxidative stress, which is now known to be a risk factor for cardiovascular events. | en_US |
dc.identifier.citation | Serdar, Z. vd. (2013). “Aspirin resistance and oxidative stress in patients with coronary artery disease”. Nobel Medicus, 9(3), 74-81. | tr_TR |
dc.identifier.endpage | 81 | tr_TR |
dc.identifier.issn | 1305-2381 | |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.scopus | 2-s2.0-84891680583 | tr_TR |
dc.identifier.startpage | 74 | tr_TR |
dc.identifier.uri | http://hdl.handle.net/11452/32584 | |
dc.identifier.volume | 9 | tr_TR |
dc.identifier.wos | 000329084300014 | tr_TR |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nobel | en_US |
dc.relation.journal | Nobel Medicus | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | General & internal medicine | en_US |
dc.subject | Aspirin | en_US |
dc.subject | Drug resistance | en_US |
dc.subject | Coronary artery disease | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Antioxidants | en_US |
dc.subject | Low-density-lipoprotein | en_US |
dc.subject | Acetylsalicylic acid | en_US |
dc.subject | Nitric-oxide | en_US |
dc.subject | Vitamin E | en_US |
dc.subject | Plasma | en_US |
dc.subject | Paraoxonase-1 | en_US |
dc.subject | Inhibition | en_US |
dc.subject | Expression | en_US |
dc.subject | Generation | en_US |
dc.subject | Markers | en_US |
dc.subject.emtree | 2, 4 dinitrophenylhydrazine | en_US |
dc.subject.emtree | Acetylsalicylic acid | en_US |
dc.subject.emtree | Alpha tocopherol | en_US |
dc.subject.emtree | Aryldialkylphosphatase | en_US |
dc.subject.emtree | Arylesterase | en_US |
dc.subject.emtree | Ascorbic acid | en_US |
dc.subject.emtree | Carbonyl derivative | en_US |
dc.subject.emtree | Carotenoid | en_US |
dc.subject.emtree | Catalase | en_US |
dc.subject.emtree | Malonaldehyde | en_US |
dc.subject.emtree | Phenylacetic acid | en_US |
dc.subject.emtree | Sialic acid | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Aged | en_US |
dc.subject.emtree | Angiocardiography | en_US |
dc.subject.emtree | Antioxidant assay | en_US |
dc.subject.emtree | Area under the curve | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Blood cell count | en_US |
dc.subject.emtree | Coronary artery disease | en_US |
dc.subject.emtree | Coronary artery obstruction | en_US |
dc.subject.emtree | Drug sensitivity | en_US |
dc.subject.emtree | Enzyme blood level | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Heart left ventricle ejection fraction | en_US |
dc.subject.emtree | High performance liquid chromatography | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Hydrolysis | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Oxidative stress | en_US |
dc.subject.emtree | Patient care | en_US |
dc.subject.emtree | Risk factor | en_US |
dc.subject.emtree | Spectrophotometry | en_US |
dc.subject.emtree | Thrombocyte function analyzer | en_US |
dc.subject.emtree | Vitamin blood level | en_US |
dc.subject.scopus | Aspirin; Acetylsalicylic Acid; Blood Clotting Parameters | en_US |
dc.subject.wos | Medicine, general & internal | en_US |
dc.title | Aspirin resistance and oxidative stress in patients with coronary artery disease | en_US |
dc.title.alternative | Koroner arter hastaları{dotless}nda aspirin direnci ve oksidatif stres | tr_TR |
dc.type | Article |
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