The IL-33 gene is related to increased susceptibility to systemic sclerosis
dc.contributor.author | Koca, Süleyman Serdar | |
dc.contributor.author | Kara, Murat | |
dc.contributor.author | Alibaz-Öner, Fatma | |
dc.contributor.author | Öztuzcu, Serdar | |
dc.contributor.author | Yılmaz, Neslihan | |
dc.contributor.author | Çetin, Gözde Yıldırım | |
dc.contributor.author | Kısacık, Bünyamin | |
dc.contributor.author | Özgen, Metin | |
dc.contributor.author | Pamuk, Ömer Nuri | |
dc.contributor.author | Direskeneli, Haner | |
dc.contributor.author | Sayarlıoğlu, Mehmet | |
dc.contributor.author | Onat, Ahmet Mesut | |
dc.contributor.buuauthor | Pehlivan, Yavuz | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı. | tr_TR |
dc.contributor.researcherid | AAG-8227-2021 | tr_TR |
dc.contributor.scopusid | 13205593600 | tr_TR |
dc.date.accessioned | 2022-10-11T06:34:24Z | |
dc.date.available | 2022-10-11T06:34:24Z | |
dc.date.issued | 2015-12-23 | |
dc.description.abstract | Systemic sclerosis (SSc) is a chronic inflammatory disease characterized by widespread fibrosis of the skin and several visceral organs. The pro-fibrotic potential of interleukin (IL)-33 has been demonstrated by in both in vitro and in vivo settings; moreover, increased level of IL-33 has also been reported in patients with SSc. Therefore, the aim of the present study was to detect the potential association of IL-33 gene polymorphisms on the susceptibility of SSc. A total of 300 SSc patients and 280 healthy controls (HC) were enrolled in this multicentric preliminary candidate gene study. DNA samples were harvested using an appropriate commercial DNA isolation kit. Four single nucleotide polymorphisms (SNPs) of IL-33 gene (rs7044343, rs1157505, rs11792633 and rs1929992) were genotyped using the appropriate commercial primer/probe sets on real-time PCR. There was no significant difference in terms of the allelic distributions and minor allele frequencies of evaluated four IL-33 polymorphisms between the SSc and HC groups (P > 0.05 for all). Moreover, the genotypic distributions of rs1157505, rs11792633 and rs1929992 polymorphisms were not significantly different (P > 0.05 for all). However, CC genotype of rs7044343 SNP was significantly higher in the SSc group compared to the HC group (P = 0.013, OR 1.75, 95 % CI 1.12-2.72). This preliminary candidate gene study demonstrates that rs7044343 polymorphism of IL-33 gene is associated with the susceptibility to the SSc in Turkish population. It may be suggested that IL-33 gene may be a candidate gene to research in SSc. | en_US |
dc.identifier.citation | Koca, S. S. vd. (2015). "The IL-33 gene is related to increased susceptibility to systemic sclerosis". Rheumatology International, 36(4), 579-584. | en_US |
dc.identifier.endpage | 584 | tr_TR |
dc.identifier.issn | 0172-8172 | |
dc.identifier.issn | 1437-160X | |
dc.identifier.issue | 4 | tr_TR |
dc.identifier.pubmed | 26743213 | tr_TR |
dc.identifier.scopus | 2-s2.0-84953372296 | tr_TR |
dc.identifier.startpage | 579 | tr_TR |
dc.identifier.uri | https://doi.org/10.1007/s00296-015-3417-8 | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00296-015-3417-8 | |
dc.identifier.uri | http://hdl.handle.net/11452/29041 | |
dc.identifier.volume | 36 | tr_TR |
dc.identifier.wos | 000374567100016 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Heidelberg | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | Rheumatology International | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Rheumatology | en_US |
dc.subject | Systemic sclerosis | en_US |
dc.subject | Genetic | en_US |
dc.subject | IL-33 gene polymorphism | en_US |
dc.subject | Human th2 cells | en_US |
dc.subject | Disease | en_US |
dc.subject | Association | en_US |
dc.subject | ST2 | en_US |
dc.subject | Scleroderma | en_US |
dc.subject | Fibrosis | en_US |
dc.subject | Interleukin-4 | en_US |
dc.subject | Polymorphisms | en_US |
dc.subject | Involvement | en_US |
dc.subject | Cytokine | en_US |
dc.subject.emtree | Genomic DNA | en_US |
dc.subject.emtree | Interleukin 33 | en_US |
dc.subject.emtree | IL33 protein, human | en_US |
dc.subject.emtree | Interleukin 33 | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Allele | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | DNA isolation | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Finger ulcer | en_US |
dc.subject.emtree | Gene frequency | en_US |
dc.subject.emtree | Genetic association | en_US |
dc.subject.emtree | Genetic susceptibility | en_US |
dc.subject.emtree | Genotype | en_US |
dc.subject.emtree | Haplotype | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Lung fibrosis | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Pulmonary hypertension | en_US |
dc.subject.emtree | Real time polymerase chain reaction | en_US |
dc.subject.emtree | Single nucleotide polymorphism | en_US |
dc.subject.emtree | Systemic sclerosis | en_US |
dc.subject.emtree | Turkish citizen | en_US |
dc.subject.emtree | Case control study | en_US |
dc.subject.emtree | Clinical trial | en_US |
dc.subject.emtree | Genetic association study | en_US |
dc.subject.emtree | Genetic predisposition | en_US |
dc.subject.emtree | Genetics | en_US |
dc.subject.emtree | Heterozygote | en_US |
dc.subject.emtree | Homozygote | en_US |
dc.subject.emtree | Immunology | en_US |
dc.subject.emtree | Middle aged | en_US |
dc.subject.emtree | Multicenter study | en_US |
dc.subject.emtree | Phenotype | en_US |
dc.subject.emtree | Risk factor | en_US |
dc.subject.emtree | Scleroderma, systemic | en_US |
dc.subject.emtree | Single nucleotide polymorphism | en_US |
dc.subject.emtree | Turkey | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Case-control studies | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gene frequency | en_US |
dc.subject.mesh | Genetic association studies | en_US |
dc.subject.mesh | Genetic predisposition to disease | en_US |
dc.subject.mesh | Heterozygote | en_US |
dc.subject.mesh | Homozygote | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Interleukin-33 | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Phenotype | en_US |
dc.subject.mesh | Polymorphism, single nucleotide | en_US |
dc.subject.mesh | Real-time polymerase chain reaction | en_US |
dc.subject.mesh | Risk factors | en_US |
dc.subject.mesh | Scleroderma, systemic | en_US |
dc.subject.mesh | Turkey | en_US |
dc.subject.scopus | Interleukin-33; Soluble; Alarmins | en_US |
dc.subject.wos | Rheumatology | en_US |
dc.title | The IL-33 gene is related to increased susceptibility to systemic sclerosis | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |
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