In vitro cytotoxic and antiproliferative effects of usnic acid on hormone-dependent breast and prostate cancer cells

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dc.contributor.authorEskiler, Gamze Güney
dc.contributor.buuauthorEryılmaz, Işıl Ezgi
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorYurdacan, Beste
dc.contributor.buuauthorÇeçener, Gülşah
dc.contributor.buuauthorTunca, Berrin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3316-316Xtr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.contributor.researcheridGWV-3548-2022tr_TR
dc.contributor.researcheridAAH-1656-2021tr_TR
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.contributor.researcheridAAP-9988-2020tr_TR
dc.contributor.scopusid57189380840tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid57203621058tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid6602965754tr_TR
dc.date.accessioned2023-10-18T12:39:27Z
dc.date.available2023-10-18T12:39:27Z
dc.date.issued2018-10
dc.description.abstractThe aim of the current study was first to investigate cytotoxic activity of usnic acid (UA) on hormone-dependent breast and prostate cancer, and normal cells. Cells were treated with increasing concentrations (25 to 150 mu M) of UA for 48hours and cell viability, quantitative and morphological analysis of cell death, and cell cycle analysis were performed. UA was shown to have selective cytotoxicity on hormone-dependent cancer cells with the IC50 levels of 71.4 and 77.5 mu M for MCF7 and LNCaP cells, respectively. UA induced apoptotic cell death and G0/G1 cell cycle arrest without damaging normal cells. MCF7 cells were more sensitive to UA than LNCaP cells. Our results first revealed that UA is a promising candidate as an alternative agent for hormone-dependent breast and prostate cancers. However, molecular mechanism underlying the UA-mediated cell death in cancer cells should be investigated further.en_US
dc.identifier.citationEryılmaz, I. E. vd. (2018). ''In vitro cytotoxic and antiproliferative effects of usnic acid on hormone-dependent breast and prostate cancer cells''. Journal of Biochemical and Molecular Toxicology, 32(10).en_US
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue10tr_TR
dc.identifier.pubmed30101414tr_TR
dc.identifier.scopus2-s2.0-85052431648tr_TR
dc.identifier.urihttps://doi.org/10.1002/jbt.22208
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/jbt.22208
dc.identifier.urihttp://hdl.handle.net/11452/34431
dc.identifier.volume32tr_TR
dc.identifier.wos000447551700009
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectToxicologyen_US
dc.subjectApoptosisen_US
dc.subjectBreast canceren_US
dc.subjectHormone-dependent cancersen_US
dc.subjectProstate canceren_US
dc.subjectUsnic aciden_US
dc.subjectAdjuvant tamoxifenen_US
dc.subjectL-methionineen_US
dc.subjectDna-damageen_US
dc.subjectTherapyen_US
dc.subjectReceptorsen_US
dc.subjectLncapen_US
dc.subjectMcf-7en_US
dc.subjectMechanismsen_US
dc.subjectApoptosisen_US
dc.subjectCompounden_US
dc.subject.emtreeHormoneen_US
dc.subject.emtreeUsnic aciden_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeBenzofuran derivativeen_US
dc.subject.emtreeUsnic aciden_US
dc.subject.emtreeAntiproliferative activityen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBreast canceren_US
dc.subject.emtreeCancer cellen_US
dc.subject.emtreeCell cycle regulationen_US
dc.subject.emtreeCell proliferationen_US
dc.subject.emtreeCell viabilityen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCytotoxicityen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeIC50en_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeLNCaP cell lineen_US
dc.subject.emtreeMCF-7 cell lineen_US
dc.subject.emtreePercentage of cells in G0/G1 phaseen_US
dc.subject.emtreeProstate canceren_US
dc.subject.emtreeBreast tumoren_US
dc.subject.emtreeCell cycle G0 phaseen_US
dc.subject.emtreeCell cycle G1 phaseen_US
dc.subject.emtreeCell lineen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNeoplasmen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeProstate tumoren_US
dc.subject.emtreeTumor cell lineen_US
dc.subject.meshAntineoplastic agentsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshBenzofuransen_US
dc.subject.meshBreast neoplasmsen_US
dc.subject.meshCell lineen_US
dc.subject.meshCell line, tumoren_US
dc.subject.meshCell proliferationen_US
dc.subject.meshFemaleen_US
dc.subject.meshG1 phaseen_US
dc.subject.meshHumansen_US
dc.subject.meshInhibitory concentration 50en_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasms, hormone dependenten_US
dc.subject.meshProstatic neoplasmsen_US
dc.subject.meshResting phase, cell cycleen_US
dc.subject.scopusUsnic Acid; Extract; Lichen (Disease)en_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosToxicologyen_US
dc.titleIn vitro cytotoxic and antiproliferative effects of usnic acid on hormone-dependent breast and prostate cancer cellsen_US
dc.typeArticle
dc.wos.quartileQ2 (Biochemistry & molecular biology)en_US
dc.wos.quartileQ3 (Toxicology)en_US

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