Coexisting endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia

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Date

2004-01

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Wiley

Abstract

Aim: To investigate the possibility of coexisting endometrial cancer (EC) in patients with atypical endometrial hyperplasia (AEH). Methods: Forty-six consecutive women who underwent hysterectomy for AEH were analyzed. Results: Final histopathological evaluation of hysterectomy specimens revealed EC in 11 patients (23.9%). Preoperative diagnosis of AEH was established by pipelle biopsy in eight patients and curettage was performed in the remaining patients. Of the patients with pipelle biopsy, two had a diagnosis of EC (25%), whereas nine women who underwent curettage, were further diagnosed as having EC (23.7%) (P > 0.05). Four (13.3%) of 30 women who had frozen sections at hysterectomy, were diagnosed with EC. Diagnosis of EC was missed in two patients (50%) at frozen section. In contrast, seven of 16 women (43.7%) who did not have frozen section, had EC. Conclusion: A relatively high incidence of EC is seen in patients with a diagnosis of AEH. Diagnostic results of pipelle biopsy and curettage were comparable. Frozen sections of hysterectomy specimens does not guarantee to exclude the possibility of EC, especially in patients with no myometrial invasion.

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Keywords

Atypical endometrial hyperplasia, Curettage, Endometrial cancer, Frozen section, Pipelle biopsy, Myometrial invasion, Carcinoma, Adenocarcinoma, Curettage, Accuracy, Depth, Obstetrics & gynecology

Citation

Bilgin, T. vd. (2004). “Coexisting endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia”. Journal Of Obstetrics And Gynaecology Research, 30(3), 205-209.