Nutritional modifiers of aging brain function: Use of uridine and other phosphatide precursors to increase formation of brain synapses
dc.contributor.author | Wurtman, Richard J. | |
dc.contributor.author | Sakamoto, Toshimasa | |
dc.contributor.author | Ulus, İsmael | |
dc.contributor.buuauthor | Cansev, Mehmet | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0003-2918-5064 | tr_TR |
dc.contributor.researcherid | M-9071-2019 | tr_TR |
dc.contributor.scopusid | 8872816100 | tr_TR |
dc.date.accessioned | 2021-11-10T08:50:28Z | |
dc.date.available | 2021-11-10T08:50:28Z | |
dc.date.issued | 2010-12 | |
dc.description.abstract | Brain phosphatide synthesis requires three circulating compounds: docosahexaenoic acid (DHA), uridine, and choline. Oral administration of these phosphatide precursors to experimental animals increases the levels of phosphatides and synaptic proteins in the brain and per brain cell as well as the numbers of dendritic spines on hippocampal neurons. Arachidonic acid fails to reproduce these effects of DHA. If similar increases occur in human brain, administration of these compounds to patients with diseases that cause loss of brain synapses, such as Alzheimer's disease, could be beneficial. | en_US |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) - USA | tr_TR |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Mental Health (NIMH) (R01MH028783) | tr_TR |
dc.identifier.citation | Wurtman, Richard. J. vd. (2010). "Nutritional modifiers of aging brain function: Use of uridine and other phosphatide precursors to increase formation of brain synapses". Nutrition Reviews, 68(12), 88-101. | en_US |
dc.identifier.endpage | 101 | tr_TR |
dc.identifier.issn | 0029-6643 | |
dc.identifier.issn | 1753-4887 | |
dc.identifier.issue | 12 | tr_TR |
dc.identifier.pubmed | 21091953 | tr_TR |
dc.identifier.scopus | 2-s2.0-78649436932 | tr_TR |
dc.identifier.startpage | 88 | tr_TR |
dc.identifier.uri | https://doi.org/10.1111/j.1753-4887.2010.00344.x | |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/21091953/ | |
dc.identifier.uri | http://hdl.handle.net/11452/22616 | |
dc.identifier.volume | 68 | tr_TR |
dc.identifier.wos | 000284587300006 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | Nutrition Reviews | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Aging brain function | en_US |
dc.subject | Nutritional modifiers | en_US |
dc.subject | Phosphatide precursors | en_US |
dc.subject | Uridine | en_US |
dc.subject | Plus docosahexaenoic acid | en_US |
dc.subject | CDP-choline levels | en_US |
dc.subject | Rat-brain | en_US |
dc.subject | Alzheimers-disease | en_US |
dc.subject | Fatty-acid | en_US |
dc.subject | Neurite outgrowth | en_US |
dc.subject | Pheochromocytoma cells | en_US |
dc.subject | Transcription factors | en_US |
dc.subject | Glutamate receptors | en_US |
dc.subject | Synaptic plasticity | en_US |
dc.subject | Nutrition & dietetics | en_US |
dc.subject | Animalia | en_US |
dc.subject.emtree | Choline | en_US |
dc.subject.emtree | Docosahexaenoic acid | en_US |
dc.subject.emtree | Omega 3 fatty acid | en_US |
dc.subject.emtree | Uridine | en_US |
dc.subject.emtree | Alzheimer disease | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Behavior | en_US |
dc.subject.emtree | Brain cell | en_US |
dc.subject.emtree | Brain development | en_US |
dc.subject.emtree | Brain function | en_US |
dc.subject.emtree | Clinical trial | en_US |
dc.subject.emtree | Cognition | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Nerve cell network | en_US |
dc.subject.emtree | Neurite | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Protein synthesis | en_US |
dc.subject.emtree | Synapse | en_US |
dc.subject.emtree | Synaptic membrane | en_US |
dc.subject.emtree | Synaptogenesis | en_US |
dc.subject.emtree | Verbal memory | en_US |
dc.subject.scopus | Choline Phosphate Cytidylyltransferase; Phosphatidylcholines; Citicoline | en_US |
dc.subject.wos | Nutrition & dietetics | en_US |
dc.title | Nutritional modifiers of aging brain function: Use of uridine and other phosphatide precursors to increase formation of brain synapses | en_US |
dc.type | Article | |
dc.wos.quartile | Q1 | en_US |