Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain
dc.contributor.buuauthor | Baǧdaş, Deniz | |
dc.contributor.buuauthor | Çinkılıç, Nilüfer | |
dc.contributor.buuauthor | Özbölük, Hasret Yücel | |
dc.contributor.buuauthor | Özyiǧit, Musa Özgür | |
dc.contributor.buuauthor | Gürün, Mine Sibel | |
dc.contributor.department | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Hayvan Yetiştiriciliği, Beslenme ve Et Araştırma Enstitüsü. | tr_TR |
dc.contributor.orcid | 0000-0002-3595-6286 | tr_TR |
dc.contributor.researcherid | AAR-6478-2021 | tr_TR |
dc.contributor.researcherid | AAG-8716-2019 | tr_TR |
dc.contributor.researcherid | AAH-5296-2021 | tr_TR |
dc.contributor.researcherid | AAH-2873-2021 | tr_TR |
dc.contributor.scopusid | 15062425700 | tr_TR |
dc.contributor.scopusid | 26533892300 | tr_TR |
dc.contributor.scopusid | 55890590200 | tr_TR |
dc.contributor.scopusid | 6507338060 | tr_TR |
dc.contributor.scopusid | 55664349700 | tr_TR |
dc.date.accessioned | 2022-06-21T11:21:25Z | |
dc.date.available | 2022-06-21T11:21:25Z | |
dc.date.issued | 2013-10 | |
dc.description.abstract | Chlorogenic acid (CGA) is a natural organic phenolic compound that is found in many plants, fruits and vegetables. CGA has beneficial bioactivities and strong therapeutic effects in inflammatory processes. CGA-rich fractions have analgesic activity but CGA has not been tested previously in neuropathic pain, which results from tissue damage, inflammation or injury of the nervous system. Chronic constrictive nerve injury (CCI) is a peripheral neuropathic pain model which initiates an inflammatory cascade. We aimed to determine possible antihyperalgesic effects of CGA in neuropathic pain. Our study showed for the first time that CGA [50, 100 and 200 mg/kg; intraperitoneally (i.p.)] produced significant dose- and time-dependent antihyperalgesic activity in CCI-induced neuropathic pain. In addition, chronic administration of CGA (100 mg/kg/day; i.p. for 14 days) prevented the development of mechanical hyperalgesia and attenuated CCI-induced histopathological changes. On the other hand, CGA (200 mg/kg) did not affect falling latencies of rats in the rota rod test. Hence, CGA might represent a novel potential therapeutic option for the management of neuropathic pain. | en_US |
dc.identifier.citation | Bağdaş, D. vd. (2013). "Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain". Journal of Natural Medicines, 67(4), 698-704. | en_US |
dc.identifier.endpage | 704 | tr_TR |
dc.identifier.issn | 1340-3443 | |
dc.identifier.issn | 1861-0293 | |
dc.identifier.issue | 4 | tr_TR |
dc.identifier.pubmed | 23203628 | tr_TR |
dc.identifier.scopus | 2-s2.0-84884205424 | tr_TR |
dc.identifier.startpage | 698 | tr_TR |
dc.identifier.uri | https://doi.org/10.1007/s11418-012-0726-z | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s11418-012-0726-z | |
dc.identifier.uri | http://hdl.handle.net/11452/27334 | |
dc.identifier.volume | 67 | tr_TR |
dc.identifier.wos | 000324116600003 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.journal | Journal of Natural Medicines | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Pharmacology & pharmacy | en_US |
dc.subject | Antihyperalgesic | en_US |
dc.subject | Chlorogenic acid | en_US |
dc.subject | Chronic constrictive nerve injury | en_US |
dc.subject | Neuropathic pain | en_US |
dc.subject | Rat | en_US |
dc.subject | Oxygen species ros | en_US |
dc.subject | Inflammatory pain | en_US |
dc.subject | Rat | en_US |
dc.subject | Polyphenols | en_US |
dc.subject.emtree | Chlorogenic acid | en_US |
dc.subject.emtree | Gabapentin | en_US |
dc.subject.emtree | Analgesic activit | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Chronic constrictive nerve injury | en_US |
dc.subject.emtree | Chronic drug administration | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Dose response | en_US |
dc.subject.emtree | Drug megadose | en_US |
dc.subject.emtree | Drug structure | en_US |
dc.subject.emtree | Histopathology | en_US |
dc.subject.emtree | Hyperalgesia | en_US |
dc.subject.emtree | Latent period | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Mechanical hyperalgesia | en_US |
dc.subject.emtree | Motor coordination | en_US |
dc.subject.emtree | Motor performance | en_US |
dc.subject.emtree | Nerve injury | en_US |
dc.subject.emtree | Neuropathic pain | en_US |
dc.subject.emtree | Nociception | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Rotarod test | en_US |
dc.subject.emtree | Single drug dose | en_US |
dc.subject.emtree | Treatment duration | en_US |
dc.subject.mesh | Analgesics | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Chlorogenic acid | en_US |
dc.subject.mesh | Hyperalgesia | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Motor activity | en_US |
dc.subject.mesh | Neuralgia | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, sprague-dawley | en_US |
dc.subject.mesh | Sciatic nerve | en_US |
dc.subject.scopus | Antioxidant; Carlina Oxide; Lonicera | en_US |
dc.subject.wos | Chemistry, medicinal | en_US |
dc.subject.wos | Pharmacology & pharmacy | en_US |
dc.title | Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |
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