Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro

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dc.contributor.buuauthorTezcan, Gülçin
dc.contributor.buuauthorTaşkapılıoğlu, Mevlut Özgür
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorDemirci, Hilal
dc.contributor.buuauthorKocaeli, Hasan
dc.contributor.buuauthorAksoy, Seçil Ak
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorCecener, Gülşah
dc.contributor.buuauthorTolunay, Şahsine
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-5472-9065tr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.contributor.orcid0000-0002-5956-8755tr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.researcheridAAI-1612-2021tr_TR
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.contributor.researcheridABB-8161-2020tr_TR
dc.contributor.researcheridAAH-3843-2020tr_TR
dc.contributor.researcheridAAW-5254-2020tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.contributor.researcheridAAP-9988-2020tr_TR
dc.contributor.scopusid25650627600tr_TR
dc.contributor.scopusid25936798300tr_TR
dc.contributor.scopusid6602965754tr_TR
dc.contributor.scopusid6603677218tr_TR
dc.contributor.scopusid57193932262tr_TR
dc.contributor.scopusid6603500567tr_TR
dc.contributor.scopusid57193933334tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid6602604390tr_TR
dc.date.accessioned2023-01-09T11:59:51Z
dc.date.available2023-01-09T11:59:51Z
dc.date.issued2017-04-10
dc.description.abstractPatients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2 mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p = 0.0001, p < 0.001, p = 0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM.en_US
dc.identifier.citationTezcan, G. vd. (2017). ''Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro''. Biomedicine and Pharmacotherapy, 90, 713-723.en_US
dc.identifier.endpage723tr_TR
dc.identifier.issn0753-3322
dc.identifier.pubmed28419967tr_TR
dc.identifier.scopus2-s2.0-85017569324tr_TR
dc.identifier.startpage713tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2017.04.022
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0753332217307813
dc.identifier.uri1950-6007
dc.identifier.urihttp://hdl.handle.net/11452/30340
dc.identifier.volume90tr_TR
dc.identifier.wos000402471000087tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.bapOUAP(T) 2013/22, 2013en_US
dc.relation.bapHDP(T)-2016/14, 2016tr_TR
dc.relation.journalBiomedicine and Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectAngiogenesisen_US
dc.subjectGlioblastoma cancer stem cellen_US
dc.subjectInvasionen_US
dc.subjectMMP2en_US
dc.subjectMMP9en_US
dc.subjectOlea europaea leaf extracten_US
dc.subjectVEGFAen_US
dc.subjectAntiangiogenic therapiesen_US
dc.subjectMesenchymal transitionen_US
dc.subjectAntioxidant activityen_US
dc.subjectOlive oilen_US
dc.subjectOleuropeinen_US
dc.subjectExpressionen_US
dc.subjectPolyphenolsen_US
dc.subjectGata6en_US
dc.subjectProliferationen_US
dc.subjectMicrorna-153en_US
dc.subject.emtreeAngiogenesis inhibitoren_US
dc.subject.emtreeBevacizumaben_US
dc.subject.emtreeGelatinase Aen_US
dc.subject.emtreeGelatinase Ben_US
dc.subject.emtreeOlea europaea extracten_US
dc.subject.emtreePlant extracten_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeVasculotropin Aen_US
dc.subject.emtreeAngiogenesis inhibitoren_US
dc.subject.emtreeBevacizumaben_US
dc.subject.emtreeGelatinase Aen_US
dc.subject.emtreeGelatinase Ben_US
dc.subject.emtreePlant extracten_US
dc.subject.emtreeVasculotropin Aen_US
dc.subject.emtreeAntiangiogenic activityen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer inhibitionen_US
dc.subject.emtreeCancer stem cellen_US
dc.subject.emtreeCell invasionen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeDrug potentiationen_US
dc.subject.emtreeGlioblastomaen_US
dc.subject.emtreeGlioblastoma cell lineen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeMigration inhibitionen_US
dc.subject.emtreeOlive treeen_US
dc.subject.emtreePlant leafen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeCancer stem cellen_US
dc.subject.emtreeCell motionen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeDrug potentiationen_US
dc.subject.emtreeGlioblastomaen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeNeovascularization (pathology)en_US
dc.subject.emtreeOlive treeen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePlant leafen_US
dc.subject.emtreeTumor cell lineen_US
dc.subject.emtreeTumor invasionen_US
dc.subject.meshAngiogenesis inhibitorsen_US
dc.subject.meshBevacizumaben_US
dc.subject.meshCell lineen_US
dc.subject.meshTumoren_US
dc.subject.meshCell movementen_US
dc.subject.meshDrug synergismen_US
dc.subject.meshGlioblastomaen_US
dc.subject.meshHumansen_US
dc.subject.meshMatrix metalloproteinase 2tr_TR
dc.subject.meshMatrix metalloproteinase 9en_US
dc.subject.meshNeoplasm invasivenessen_US
dc.subject.meshNeoplastic stem cellsen_US
dc.subject.meshNeovascularization, pathologicen_US
dc.subject.meshOleaen_US
dc.subject.meshPlant extractsen_US
dc.subject.meshPlant leavesen_US
dc.subject.meshVascular endothelial growth factor Aen_US
dc.subject.scopusCancer Stem Cell; Insurance Markets; Operational Risken_US
dc.subject.wosMedicine, research & experimentalen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleOlea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitroen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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