Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception
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Date
2004-12-10
Journal Title
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Publisher
Elsevier
Abstract
This study investigated whether the lateral hypothalamus (LH) contributes to the depressor response evoked by somato-visceral nociception. Lidocame (2%; 0.1, 0.3 or 1.0 mul) or muscimol (0.34 nmol; 0.5 mul) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Lidocaine and muscimol inhibited the hypotension and bradycardia caused by somato-visceral nociception significantly without affecting cardiovascular function in normotensive animals.
Description
Keywords
Neurosciences and neurology, Lateral hypothalamus, Visceral nociception, Pain, GABA receptor, Muscimol, Cardiovascular regulation, Midbrain periaqueductal gray, Anterior hypothalamus, Efferent projections, Fos, Area, Immunoreactivity, Organization, Stimulation, Nucleus, Neurons
Citation
Göktalay, G. vd. (2004). “Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception”. Brain Research , 1029(1), 124-130.