Assesment of perfusion in glial tumors with arterial spin labeling; comparison with dynamic susceptibility contrast method
dc.contributor.author | Öztürk, Esin Işık | |
dc.contributor.author | Gümüş, Caner | |
dc.contributor.author | İnecikli, Mehmet Fatih | |
dc.contributor.buuauthor | Cebeci, Hakan | |
dc.contributor.buuauthor | Aydın, Ömer | |
dc.contributor.buuauthor | Bekar, Ahmet | |
dc.contributor.buuauthor | Kocaeli, Hasan | |
dc.contributor.buuauthor | Hakyemez, Bahattin | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Beyin ve Sinir Cerrahisi Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-3425-0740 | tr_TR |
dc.contributor.researcherid | AAI-2318-2021 | tr_TR |
dc.contributor.scopusid | 56033553000 | tr_TR |
dc.contributor.scopusid | 55933661900 | tr_TR |
dc.contributor.scopusid | 6603677218 | tr_TR |
dc.contributor.scopusid | 6603500567 | tr_TR |
dc.contributor.scopusid | 6602527239 | tr_TR |
dc.date.accessioned | 2022-08-25T08:40:45Z | |
dc.date.available | 2022-08-25T08:40:45Z | |
dc.date.issued | 2014-10 | |
dc.description.abstract | Purpose: Arterial spin labeling perfusion imaging (ASL-PI) is a non-invasive perfusion imaging method that can be used for evaluation and quantification of cerebral blood flow (CBF). Aim of our study was to evaluating the efficiency of ASL in histopathological grade estimation of glial tumors and comparing findings with dynamic susceptibility contrast perfusion imaging (DSC-PI) method. Methods: This study involved 33 patients (20 high-grade and 13 low-grade gliomas). Multiphase multislice pulsed ASL MRI sequence and a first-passage gadopentetate dimeglumine T2*-weighted gradient-echo single-shot echo-planar sequence were acquired for all the patients. For each patient, perfusion relative signal intensity (rSI), CBF and relative CBF (rCBF) on ASL-PI and relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF) values on DSC-PI were determined. The relative signal intensity of each tumor was determined as the maximal SI within the tumor divided by SI within symetric region in the contralateral hemisphere on ASL-PI. rCBV and rCBF were calculated by deconvolution of an arterial input function. Relative values of the lesions were obtained by dividing the values to the normal appearing symmetric region on the contralateral hemisphere. For statistical analysis, Mann-Whitney ranksum test was carried out. Receiver operating characteristic curve (ROC) analysis was performed to assess the relationship between the rCBF-ASL, rSI-ASL, rCBV and rCBF ratios and grade of gliomas. Their cut-off values permitting best discrimination was calculated. The correlation between rCBV, rCBF, rSI-ASL and rCBF-ASL and glioma grade was assessed using Spearman correlation analysis. Results: There was a statistically significant difference between low and high-grade tumors for all parameters. Correlation analyses revealed significant positive correlations between rCBV and rCBF-ASL (r=0.81, p<0.001). However correlation between rCBF and rCBF-ASL was weaker (r=0.64, p<0.001). Conclusion: Arterial spin labeling is an employable imaging technique for evaluating tumor perfusion non-invasively and may be useful in differentiating high and low grade gliomas. | en_US |
dc.identifier.citation | Cebeci, H. vd. (2014). "Assesment of perfusion in glial tumors with arterial spin labeling; comparison with dynamic susceptibility contrast method". European Journal of Radiology, 83(10), 1914-1919. | en_US |
dc.identifier.endpage | 1919 | tr_TR |
dc.identifier.issn | 0720-048X | |
dc.identifier.issn | 1872-7727 | |
dc.identifier.issue | 10 | tr_TR |
dc.identifier.pubmed | 25087109 | tr_TR |
dc.identifier.scopus | 2-s2.0-85027950083 | tr_TR |
dc.identifier.startpage | 1914 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.ejrad.2014.07.002 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0720048X14003544 | |
dc.identifier.uri | http://hdl.handle.net/11452/28364 | |
dc.identifier.volume | 83 | tr_TR |
dc.identifier.wos | 000341417000031 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Ireland | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | European Journal of Radiology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Glioma | en_US |
dc.subject | Dynamic susceptibility contrast perfusion imaging | en_US |
dc.subject | Arterial spin labeling | en_US |
dc.subject | Cerebral blood-volume | en_US |
dc.subject | Brain-tumors | en_US |
dc.subject | Enhanced MR | en_US |
dc.subject | Imaging techniques | en_US |
dc.subject | Gliomas | en_US |
dc.subject | Echo | en_US |
dc.subject | Maps | en_US |
dc.subject | Quantification | en_US |
dc.subject | Diagnosis | en_US |
dc.subject | Utility | en_US |
dc.subject | Radiology, nuclear medicine & medical imaging | en_US |
dc.subject.emtree | Gadolinium pentetate meglumine | en_US |
dc.subject.emtree | Contrast medium | en_US |
dc.subject.emtree | Gadodiamide | en_US |
dc.subject.emtree | Gadolinium pentetate | en_US |
dc.subject.emtree | Spin labeling | en_US |
dc.subject.emtree | Adolescent | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Aged | en_US |
dc.subject.emtree | Arterial spin labeling perfusion imaging | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Brain blood flow | en_US |
dc.subject.emtree | Brain blood volume | en_US |
dc.subject.emtree | Cancer grading | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Comparative study | en_US |
dc.subject.emtree | Correlation analysis | en_US |
dc.subject.emtree | Echo planar imaging | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Glioma | en_US |
dc.subject.emtree | Hemisphere | en_US |
dc.subject.emtree | Histopathology | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nuclear magnetic resonance imaging | en_US |
dc.subject.emtree | Nuclear magnetic resonance scanner | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rank sum test | en_US |
dc.subject.emtree | Receiver operating characteristic | en_US |
dc.subject.emtree | Scintigraphy | en_US |
dc.subject.emtree | Spin labeling | en_US |
dc.subject.emtree | Blood volume | en_US |
dc.subject.emtree | Brain circulation | en_US |
dc.subject.emtree | Brain tumor | en_US |
dc.subject.emtree | Diagnostic use | en_US |
dc.subject.emtree | Glioma | en_US |
dc.subject.emtree | Middle aged | en_US |
dc.subject.emtree | Pathology | en_US |
dc.subject.emtree | Procedures | en_US |
dc.subject.emtree | Sensitivity and specificity | en_US |
dc.subject.emtree | Vascularization | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Blood volume | en_US |
dc.subject.mesh | Brain neoplasms | en_US |
dc.subject.mesh | Cerebrovascular circulation | en_US |
dc.subject.mesh | Contrast media | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gadolinium DTPA | en_US |
dc.subject.mesh | Glioma | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Magnetic resonance imaging | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Sensitivity and specificity | en_US |
dc.subject.mesh | Spin labels | en_US |
dc.subject.scopus | Brain Circulation; Arterial Spin Labeling; Magnetic Resonance Angiography | en_US |
dc.subject.wos | Radiology, nuclear medicine & medical imaging | en_US |
dc.title | Assesment of perfusion in glial tumors with arterial spin labeling; comparison with dynamic susceptibility contrast method | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 | en_US |
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