Somatic SNPs of the BRCA2 gene at the fragments encoding RAD51 binding sites of canine mammary tumors

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dc.contributor.authorÖzmen, Özge
dc.contributor.authorKul, Selim
dc.contributor.authorRişvanlı, Ali
dc.contributor.authorSabuncu, Ahmet
dc.contributor.authorKul, Oǧuz
dc.contributor.buuauthorÖzalp, Gözde Rabia
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi.tr_TR
dc.contributor.orcid0000-0003-4694-6937tr_TR
dc.contributor.researcheridAAE-3607-2019tr_TR
dc.contributor.scopusid23985710500tr_TR
dc.date.accessioned2023-01-16T08:30:39Z
dc.date.available2023-01-16T08:30:39Z
dc.date.issued2017-12
dc.description.abstractMammary tumors are the most common tumor type both in women and in female dogs. In women, heritable breast cancers have been linked mutations in the breast cancer susceptibility gene BRCA2 and it contains eight BRC repeats in exon 11 that bind to RAD51. In this study, we investigated the sequence variations of BRC1-BRC8 and C-terminus of canine BRCA2 gene. From a total of 64 canine patients with mammary tumors, 31 mammary tumors with benign and malign carcinomas and the 3 normal mammary glands were used for the study. In this study, 19 SNPs of exon 11 of BRCA2 in canine mammary tumors were detected for the first time. The c.2383A>C (T1425P) SNP was found to be the most probable disease-associated nsSNP. Our findings suggest that T1425P variation in BRC3 to be the most probable disease-associated nsSNP and may affect RAD51 binding strength.en_US
dc.description.sponsorshipFırat Üniversitesi- VF1311tr_TR
dc.identifier.citationÖzmen, Ö. vd. (2017). ''Somatic SNPs of the BRCA2 gene at the fragments encoding RAD51 binding sites of canine mammary tumors''. Veterinary and Comparative Oncology, 15(4), 1479-1486.en_US
dc.identifier.endpage1486tr_TR
dc.identifier.issn1476-5810
dc.identifier.issue4tr_TR
dc.identifier.pubmed28133886tr_TR
dc.identifier.scopus2-s2.0-85011032599tr_TR
dc.identifier.startpage1479tr_TR
dc.identifier.urihttps://doi.org/10.1111/vco.12293
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/vco.12293
dc.identifier.uri1476-5829
dc.identifier.urihttp://hdl.handle.net/11452/30470
dc.identifier.volume15tr_TR
dc.identifier.wos000414681400031tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalVeterinary and Comparative Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVeterinary sciencesen_US
dc.subjectBRCA2en_US
dc.subjectCMTen_US
dc.subjectDogen_US
dc.subjectRAD51en_US
dc.subjectSNPsen_US
dc.subjectProteinsen_US
dc.subjectSequenceen_US
dc.subjectRepeatsen_US
dc.subject.emtreeRad51 proteinen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeDogen_US
dc.subject.emtreeDog diseaseen_US
dc.subject.emtreeExperimental mammary neoplasmen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreeSingle nucleotide polymorphismen_US
dc.subject.emtreeTumor suppressor geneen_US
dc.subject.emtreeVeterinaryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDog diseasesen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, BRCA2en_US
dc.subject.meshMammary neoplasms, animalen_US
dc.subject.meshPolymerase chain reactionen_US
dc.subject.meshPolymorphism, single nucleotideen_US
dc.subject.meshRad51 recombinaseen_US
dc.subject.scopusBRCA1 Protein; Homologous Recombination; Breast Neoplasmsen_US
dc.subject.wosVeterinary Sciencesen_US
dc.titleSomatic SNPs of the BRCA2 gene at the fragments encoding RAD51 binding sites of canine mammary tumorsen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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