Browsing by Author "Ak, Guntulu"

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    Publication
    Anxiety and depression levels of healthcare workers during covid-19 pandemic
    (European Respiratory Soc Journals, 2021-09-05) Turan, Muzaffer Onur; Demirci, Nilgun Yilmaz; Ak, Guntulu; Akcay, Sule; Akturk, Ulku Aka; Bilaceroglu, Semra; ; Kokturk, Oguz; Mirici, Arzu; Cengiz, Ozdemi. R.; Sen, Nazan; Yilmaz, Ulku; Coşkun, Funda; COŞKUN, NECMİYE FUNDA; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0001-6160-3778; 0000-0001-8849-193X; 0000-0002-9703-9598; 0000-0003-3604-8826; 0000-0002-4171-7484; AFP-3587-2022; O-8969-2018; C-9348-2014; HKN-2974-2023; JAI-8635-2023; AAD-1271-2019
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    Publication
    Effect of asbestos exposure on the frequency of egfr mutations and alk/ros1 rearrangements in patients with lung adenocarcinoma a multicentric study
    (Lippincott Williams & Wilkins, 2021-03-01) Yilmaz, Senay; Demirci, Nilgun Yilmaz; Metintas, Selma; Zamani, Adil; Kabalak, Pinar Akin; Yilmaz, Ulku; Ak, Guntulu; Kizilgoz, Derya; Ozturk, Akin; Yilmaz, Ufuk; Batum, Ozgur; Kavas, Murat; Serifoglu, Irem; Unsal, Meftun; Komurcuoglu, Berna E.; Cengiz, Tuba Inal; Ulubay, Gaye; Ozdemirel, Tugce S.; Ozyurek, Berna A.; Kavurgaci, Suna; Alizoroglu, Dursun; Celik, Pinar; Erdogan, Yurdanur; In, Erdal; Aksoy, Asude; Altin, Sedat; Gunluoglu, Gulsah; Metintas, Muzaffer; Karadag, Mehmet; KARADAĞ, MEHMET; Guclu, Ozge A.; AYDIN GÜÇLÜ, ÖZGE; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-0523-7819; 0000-0001-6160-3778; 0000-0002-9027-1132; 0000-0003-1005-3205; 0000-0001-8849-193X; 0000-0002-3445-3804; 0000-0002-2806-4781; 0000-0002-2877-242X; 0000-0003-1596-0082; 0000-0003-0206-7615; 0000-0002-8807-5853; 0000-0002-5609-9658; HKN-2974-2023; HNT-0352-2023; AAS-6628-2021; AAG-9930-2019; AFT-6588-2022; AET-7187-2022; D-2127-2014; JWA-4269-2024; AFP-3587-2022; HLH-3244-2023; C-9348-2014; AAG-8744-2021
    Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.