Publication: Effect of asbestos exposure on the frequency of egfr mutations and alk/ros1 rearrangements in patients with lung adenocarcinoma a multicentric study
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Date
2021-03-01
Authors
Authors
Yilmaz, Senay
Demirci, Nilgun Yilmaz
Metintas, Selma
Zamani, Adil
Kabalak, Pinar Akin
Yilmaz, Ulku
Ak, Guntulu
Kizilgoz, Derya
Ozturk, Akin
Yilmaz, Ufuk
Journal Title
Journal ISSN
Volume Title
Publisher
Lippincott Williams & Wilkins
Abstract
Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.
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Keywords
Anaplastic lymphoma kinase, Factor receptor-mutations, Targeted therapy, Cancer, Association, Smoking, Classification, Epidemiology, Expression, Society, Alk, Asbestos, Egfr, Genetic alterations, Lung adenocarcinoma, Ros1, Science & technology, Life sciences & biomedicine, Public, environmental & occupational health, Public, environmental & occupational health