Browsing by Author "Coşkun, Funda"

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Ace gene i/d polymorphism and risk of sarcoidosis development in Turkish patients
(Turkish Assoc Tuberculosis & Thorax, 2012-01-01) Yılmaz, Dilber; Karkucak, Mutlu; Coşkun, Funda; COŞKUN, NECMİYE FUNDA; Yakut, Tahsin; Uzaslan, Esra Kunt; UZASLAN, AYŞE ESRA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 0000-0003-3604-8826; AAD-1271-2019; AAI-1004-2021; ABI-5648-2022
Introduction: Etiology of sarcoidosis is unknown but the prevalence of disease in different ethnic groups and identical twins, family characteristics indicate that genetic predisposition is a possible factor. The angiotensin-converting enzyme (ACE) has been implicated in the pahophysiology of sarcoidosis. The aim of this study is to investigate the influence of a polymorphism in I/D (Insertion/Deletion) of the ACE gene on the susceptibility to sarcoidosis.Patients and Methods: Our study included 70 Turkish patients who had histopathological diagnosis of sarcoidosis and 69 healthy age and sex matched control subjects. Polymerase chain reaction was used for analysing an I/D polymorphism in the gene coding for ACE. Genotyping was done according to bands that were formed on the agarose gel electrophoresis. Chi-square test was used for statistical analysis and p<0.05 was accepted as significance.Results: Although the D allele was more frequent in the sarcoidosis patients group, the frequency of the D allele was 67% and 54% respectively in the sarcoidosis and the control group. No significant difference in allele frequencies of I/I, I/D, D/D polymorphisms was observed between the sarcoidosis and control group (p> 0.05). Similarly allele frequencies of I/I, I/D, D/D polymorphisms was not different between sarcoidosis patients with extrapulmonary involvement and sarcoidosis patients without extrapulmonary involvement (p> 0.05).Conclusion: Our findings have showed that contribution of ACE gene polymorphisms to susceptibility of disease development in Turkish sarcoidosis patients is not different from the healthy control subjects.
An analysis of patients diagnosed with pulmonary embolism in terms of clinical and meteorological data
(Saudi Medical Journal, 2006) Ercan, İlker; Coşkun, Funda; Cangür, Şengül; Ursavaş, Ahmet; Uzaslan, Esra; Ege, Ercüment; Kan, İ.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı.; 0000-0003-3604-8826; 0000-0002-2382-290X; AAD-1271-2019; AAI-3169-2021; 6603789069; 21734137500; 8604063700; 8329319900; 8761653500; 6701341320; 15032979000
Anxiety and depression levels of healthcare workers during covid-19 pandemic
(European Respiratory Soc Journals, 2021-09-05) Turan, Muzaffer Onur; Demirci, Nilgun Yilmaz; Ak, Guntulu; Akcay, Sule; Akturk, Ulku Aka; Bilaceroglu, Semra; ; Kokturk, Oguz; Mirici, Arzu; Cengiz, Ozdemi. R.; Sen, Nazan; Yilmaz, Ulku; Coşkun, Funda; COŞKUN, NECMİYE FUNDA; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0001-6160-3778; 0000-0001-8849-193X; 0000-0002-9703-9598; 0000-0003-3604-8826; 0000-0002-4171-7484; AFP-3587-2022; O-8969-2018; C-9348-2014; HKN-2974-2023; JAI-8635-2023; AAD-1271-2019
Associated factors with short-term mortality in pulmonary thromboembolism patients
(European Respiratory, 2015-09-01) Çetinoğlu, Ezgi Demirdöğen; Dilektaşlı, Aslı Görek; Güçlü, Özge Aydın; Özkaya, Güven; Coşkun, Funda; Ursavaş, Ahmet; Karadağ, Mehmet; Çetinoğlu, Ezgi Demirdöğen; GÖREK DİLEKTAŞLI, ASLI; AYDIN GÜÇLÜ, ÖZGE; ÖZKAYA, GÜVEN; COŞKUN, NECMİYE FUNDA; URSAVAŞ, AHMET; KARADAĞ, MEHMET; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı; 0000-0002-7400-9089; 0000-0001-7099-9647; 0000-0003-1005-3205; 0000-0003-0297-846X; 0000-0003-3604-8826; 0000-0002-9027-1132; JPK-7012-2023; AAG-8744-2021; AAI-3169-2021; AAD-1271-2019; A-4421-2016; AAG-9930-2019; AAH-9812-2021; DTT-7416-2022
Association between self reported snoring, STOP questionnaire and postoperative pulmonary complications in patients submitted to ortophaedic surgery
(Pagepress Publication, 2013-01-18) Ursavaş, Ahmet; Güven, Tahir; Coşkun, Funda; Ege, Ercüment; Yılmazlar, Aysun; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji Anabilim Dalı.; 0000-0003-3604-8826; AAD-1271-2019; AAI-3169-2021; 8329319900; 46761035100; 21734137500; 6701341320; 55899579900
Background: Obstructive sleep apnea (OSA) may increase perioperative complications. The aim of this study was to determine the relationship among postoperative pulmonary complication, snoring and STOP questionnaire in patients with ortophaedic surgery. Methods: 1,406 consecutive records of patients who had undergone elective ortophaedic surgery during the period January 2005-December 2008 were investigated retrospectively. Demographic information, sleep symptoms, STOP questionnaire, comorbidities and outcome data were collected. Results: There were 289 (20.5%) snorers and 1,117 (79.5%) non-snorers in the study group. There was no significant difference between snorer and non-snorer patients (p > 0.05) in the prevalence of pneumonia and respiratory failure. But in snorer patients the rate of postoperative atelectasis was significantly higher than in non-snorer group (p < 0.0001). The STOP Questionnaire was given to 1,406 patients and 147 (10.4%) out of them were classified at high risk of OSA. There was no significant difference in the prevalence of pneumonia and respiratory failure between low and high risk group (p > 0.05). However, in high risk patients the occurrence of postoperative atelectasis was significantly higher than in low risk group (p < 0.0001). Conclusion: Postoperative atelectasis was significantly more prevalent in the high risk group according to STOP questionnaire.
Atopy and allergic diseases frequency in stable sarcoidosis patients
(Wiley, 2015-12-01) Uzaslan, Ayşe Esra; Savaş, Nazan Nalcı; Uzaslan, Esra; Ediger, Dane; Coşkun, Funda; Ursavaş, Ahmet; Gözu, Oktay; Savaş, Nazan Nalcı; UZASLAN, AYŞE ESRA; EDİGER, DANE; COŞKUN, NECMİYE FUNDA; URSAVAŞ, AHMET; Gözu, Oktay; Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-2954-4293; 0000-0003-3604-8826; AAD-1271-2019; AAI-3169-2021; AAE-9142-2019; EDM-6718-2022; IOL-2975-2023; CDI-1977-2022; JLC-5863-2023
AVAPS-NIV treatment in hypercapnic respiratory failure with insufficient response to fixed-level PS-NIV
(Türk Tüberküloz ve Toraks, 2022-01-01) Öztürk, Nilüfer Aylın Acet; Güçlü, Özge Aydın; Demirdöğen, Ezgi; Dilektaşlı, Asli Görek; Maharramov, Shahriyar; Coşkun, Funda; Uzaslan, Esra; Ursavaş, Ahmet; Karadağ, Mehmet; ACET ÖZTÜRK, NİLÜFER AYLİN; AYDIN GÜÇLÜ, ÖZGE; DEMİRDÖĞEN, EZGİ; GÖREK DİLEKTAŞLI, ASLI; Maharramov, Shahriyar; COŞKUN, NECMİYE FUNDA; UZASLAN, AYŞE ESRA; URSAVAŞ, AHMET; KARADAĞ, MEHMET; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı; 0000-0002-6375-1472; 0000-0003-1005-3205; 0000-0002-7400-9089; 0000-0001-7099-9647; 0000-0003-3604-8826; 0000-0002-9027-1132; AAI-3169-2021; AAD-1271-2019; AAG-8744-2021; JPK-7012-2023; DTT-7416-2022; DDT-7334-2022
Introduction: Noninvasive ventilation (NIV) for acute hypercapnic respiratory failure (AHRF) is an established treatment modality. Current evidence does not conclude any superiority between fixed pressure support (PS) and aver-age volume-assured pressure support (AVAPS) modes. However, given the ability of rapid PaCO2 decline in AVAPS mode, we hypothesized that COPD patients with AHRF who did not show the desired reduction in PaCO2 with fixed-level PS-NIV might benefit from the AVAPS mode.Materials and Methods: Patients admitted to the non-ICU pulmonary ward with acute exacerbation of COPD (AECOPD) and AHRF were included con-secutively in this observational study. Patients with hypercapnic respiratory failure due to obesity-hypoventilation, neurological diseases, or chest wall deformities were excluded. All patients started NIV treatment with fixed pres-sure support (PS) and patients who did not reach clinical and laboratory stability under PS-NIV treatment were switched to the average volume -as-sured pressure support (AVAPS) mode of NIV.Results: Thirty-five COPD patients with hypercapnic respiratory failure were included. Under PS-NIV treatment, 14 (40%) patients showed a 17.9 (-0.0-29.2) percent change in terms of PaCO2 , meaning no improvement or worsening. Therefore, these patients were treated with AVAPS mode. Arterial PaCO2 and pH levels significantly improved after AVAPS-NIV administration. AVAPS-NIV treatment created a significantly better PaCO2 change rate than using PS-NIV (-11.4 (-22.0 --0.5)vs 8.2 (-5.3-19.5), p= 0.02]. Independent predictors of AVAPS mode requirement were higher Charlson Comorbidity Index (OR= 1.74 (95% CI= 1.02-2.97)] and higher PaCO2 upon admission (OR= 1.18 (95% CI= 1.03-1.35)]. Thirteen (92.8%) patients reaching signif-icant clinical stability with AVAPS-NIV were able to return to fixed-level PS-NIV and maintain acceptable PaCO2 levels.Conclusion: Our study demonstrated that patients can benefit from AVAPS-NIV despite insufficient response to fixed-level PS-NIV.
The beneficial effects of preperitoneal catheter analgesia following colon and rectal resections: A prospective, randomized, double-blind, placebo-controlled study
(Springer, 2011-09) Öztürk, Ersin; Yılmazlar, Aysun; Coşkun, Funda; Işık, Özgen; Yılmazlar, Tuncay; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Akciğer Bilimleri Anabilim Dalı.; 0000-0002-9541-5035; 0000-0003-3604-8826; P-5779-2019; AAD-1271-2019; 35070171400; 55899579900; 21734137500; 36600543700; 6701800362
Preperitoneal catheter analgesia following abdominal surgery has attracted interest in the last decade. We conducted this study to evaluate the benefits of preperitoneal catheter analgesia in managing pain after abdominal colon and rectal resections. A total of 50 patients undergoing colon and rectal resections for benign and malignant diseases received analgesic medicines via an epidural catheter placed just prior to surgery and a preperitoneal catheter placed at the end of the surgical procedure. Patients were instructed to use the epidural patient-controlled analgesia (PCA) device freely and were randomized into two groups after obtaining the approval of the Institutional Review Board: Group A received 10 ml of levobupivacaine twice a day postoperatively via preperitoneal catheter and group B received only 10 ml of saline. Demographics, surgical characteristics, pain scores recorded four days following surgery, analgesic volume used from the epidural PCA, clinical outcomes (length of stay, time to first bowel movement, time to first passage of gas or stool, time to first oral intake) and respiratory function test results (preoperative vs. postoperative) were compared. There were no significant differences in demographics or surgical characteristics between both groups. Pain scores were similar. Clinical outcomes and respiratory functions were comparable. The use of analgesic volume via epidural catheter was significantly lower in group A than in group B (P = 0.032). Preperitoneal catheter analgesia significantly decreased the need for epidural drug consumption and proved to be a beneficial adjunct for postoperative pain management of patients who underwent colon and rectal resections.
Breast and osteoarticular tuberculosis in a male patient
(Elsevier, 2007-03-11) Ursavaş, Ahmet; Eğe, Ercüment; Bilgen, Ömer Faruk; Taşdelen, İsmet; Coşkun, Funda; Sönmez, Sevginar; Gözü, Ramazan Oktay; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; 0000-0003-3604-8826; AAD-1271-2019; AAI-3169-2021; 8329319900; 6701341320; 16933501900; 9637821500; 21734137500; 18134627600; 15836640800
Breast tuberculosis is an uncommon illness. It is predominant in young women. To our knowledge, only 7 cases of tuberculous mastitis in men have been reported in the English literature since 1945. Furthermore, there are no male patients who have breast and osteoarticular tuberculosis in the literature. We presented a 4 1 -year-old man who was admitted with a fixed tender mass in the right retromammary region and pain in the right hip. Mycobacterium tuberculosis colonies were isolated from the semisolid mass of breast. Histopathologic examination revealed caseous granulomatous infection in the right hip synovial tissue. He was treated successfully with only antituberculous drugs. (C) 2007 Elsevier Inc. All rights reserved.
A case of Hodgkin's lyphoma which caused pericardial tamponade in a young female patient
(Bayçınar Tıbbi Yayıncılık, 2012-07) Coşkun, Funda; Bayram, Ahmet Sami; Özdemir, Bülent; Biçer, Murat; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; 0000-0003-3604-8826; ABC-2231-2020; AAD-1271-2019; ABB-7580-2020; 21734137500; 8347194000; 7004168959; 6507770944
Malignant pericardial effusions (MPE) account for approximately 21% of all patients with advanced malignancies. The standard approach to management of MPE has remained controversial. In this article, we present the case of an 18-year-old female who was admitted to our clinic with pericardial tamponade. A cytological examination of the pericardial effusion revealed malignant cells, and the biopsy confirmed the diagnosis of Hodgkin's lymphoma of the nodular sclerosing type.
Catheter-directed therapy in acute pulmonary embolism with right ventricular dysfunction: A promising modality to provide early hemodynamic recovery
(Int Scientific Information, 2016-04-15) Dilektaşlı, Aslı Görek; Çetinoğlu, Ezgi Demirdoğen; Acet, Nilüfer Aylin; Erdoğan, Cüneyt; Ursavaş, Ahmet; Özkaya, Güven; Coşkun, Funda; Karadağ, Mehmet; Ege, Ercüment; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-9027-1132; 0000-0002-6375-1472; 0000-0003-3604-8826; 0000-0003-0297-846X; AAG-8744-2021; Z-1424-2019; AAD-1271-2019; A-4421-2016; AAI-3169-2021; 36466376600; 57189524206; 56507253300; 8293835700; 8329319900; 16316866500; 21734137500; 6601970351; 6701341320
Background: Catheter-directed therapy (CDT) for pulmonary embolism (PE) is considered as an alternative to systemic thrombolysis (ST) in patients with hemodynamically unstable acute PE who are considered at high bleeding risk for ST. We aimed to evaluate the efficacy and safety of CDT in the management of acute PE with right ventricular dysfunction (RVD). The primary outcomes were mortality, clinical success, and complications. Secondary outcomes were change in hemodynamic parameters in the first 24 hours following the procedure. Material/Methods: Medical records of consecutive patients diagnosed as having acute massive or submassive PE with accompanying RVD treated by immediate CDT at our institution from January 2007 to January 2014 were reviewed. Patient characteristics, mortality, achievement of clinical success, and minor and major bleeding complications were analyzed in the overall study group, as well as massive vs. submassive PE subgroups. Change in hemodynamic parameters in the second, eighth, and 24th hours after the CDT procedure were also analyzed. Results: The study included 15 consecutive patients (M/F=10/5) with a mean age of 54.2 +/- 16.6 years who underwent immediate CDT. Nine of the patients had submassive PE, and 6 had massive PE. In-hospital mortality rate was 13.3% (95% CI, 0.04-0.38). One major, but not life-threatening, bleeding episode was evident in the whole group. Hemodynamic parameters were stabilized and clinical success was achieved in 14/15 (93.3%; 95% CI, 70.2-98.8) of the patients in the first 24 hours. Notably, the hemodynamic recovery was significantly evident in the first 8 hours after the procedure. Conclusions: CDT is a promising treatment option for patients with acute PE with RVD with no fatal bleeding complication. In experienced centers, CDT should be considered as a first-line treatment for patients with acute PE and RVD and contraindications for ST, with the advantage of providing early hemodynamic recovery.
Changes in myocardial performance in sarcoidosis patients
(Amer, 2015-10-01) Kederli, Aysel; Güllülü, Sümeyye; Coşkun, Funda; Yılmaz, Dilber; Uzaslan, Esra; Kederli, Aysel; GÜLLÜLÜ, NAZMİYE SÜMEYYE; COŞKUN, NECMİYE FUNDA; Yılmaz, Dilber; UZASLAN, AYŞE ESRA; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı; 0000-0003-3604-8826; AAD-1271-2019; CZE-7153-2022; EXG-3181-2022; EGU-1690-2022; CDI-1977-2022
Clinical course and diagnostic work-up of sarcoidosis: retrospective analysis of a 10-year experience
(Amer Thoracic Soc, 2014) Dilektaşlı, Aslı Görek; Çetinoğlu, Ezgi Demirdöğen; Coşkun, Funda; Ursavas, Ahmet; Uzaslan, Esra; Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-3604-8826; AAI-3169-2021; AAD-1271-2019
Clinical, functional characteristics and exercise capacity of the frequent exacerbator copd phenotype
(Amer Thoracic Soc, 2015-01-01) Uzaslan, Esra; Dilektaşlı, Aslı Görek; Çetinoğlu, Ezgi Demirdogen; Budak, Ferah; Coşkun, Funda; Ursavas, Ahmet; Ege, Ercüment; UZASLAN, AYŞE ESRA; GÖREK DİLEKTAŞLI, ASLI; Çetinoğlu, Ezgi Demirdogen; BUDAK, FERAH; COŞKUN, NECMİYE FUNDA; URSAVAŞ, AHMET; Ege, Ercüment; Uludağ Üniversitesi; 0000-0001-7099-9647; 0000-0002-7400-9089; 0000-0001-7625-9148; 0000-0003-3604-8826; JPK-7012-2023; F-4657-2014; AAD-1271-2019; AAI-3169-2021; IZP-9398-2023; CDI-1977-2022; DTT-7416-2022; AAH-9812-2021
Coagulopathy and COVID-19
(Kare Yayınevi, 2020-05-18) Yazıcı, Onur; Bozkuş, Fulsen; Demirci, Nilgün; Gülhan, Pınar Yıldız; Coşkun, Funda; COŞKUN, NECMİYE FUNDA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 0000-0003-3604-8826; AAD-1271-2019
Caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) is a potentially fatal disease as a global public health issue. Several mechanisms may be involved in mortality. One of these is coagulopathy and disseminated intravascular coagulation caused by SARS-CoV-2. When patients have coagulation disorders, treatment becomes more challenging and mortality rate increases accordingly. The aim of this article is to review the potential mechanisms of coagulopathy in COVID-19 in light of literature data.
Comorbidies in patients hospitalized for acute exacerbation of copd
(Wiley, 2013-11-01) Dilektaşlı, Aslı Görek; Çetinoğlu, Ezgi Demirdoğen; Coşkun, Funda; Özkaya, Güven; Ege, Ercüment; Uzaslan, Esra; GÖREK DİLEKTAŞLI, ASLI; Çetinoğlu, Ezgi Demirdoğen; COŞKUN, NECMİYE FUNDA; ÖZKAYA, GÜVEN; Ege, Ercüment; UZASLAN, AYŞE ESRA; Uludağ Üniversitesi/Tıp Fakültesi/Biyostat Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Diş Bölümü; 0000-0001-7099-9647; 0000-0002-7400-9089; 0000-0003-3604-8826; 0000-0003-0297-846X; AAD-1271-2019; JPK-7012-2023; A-4421-2016; DTT-7416-2022; AAH-9812-2021; CPF-5844-2022; CDI-1977-2022
Determinants of dynamic hyperinflation during metronome-paced tachypnea in COPD and normal subjects
(Elsevier, 2013-08-01) Cooper, Christopher B.; Calligaro, Gregory L.; Quinn, M. M.; Eshaghian, Patricia H.; Abrazado, Marlon L.; Raine, Richard I.; Coşkun, Funda; Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-3604-8826; AAD-1271-2019; 21734137500
In COPD, dynamic hyperinflation (DH) occurs during exercise and during metronome-paced tachypnea (MPT). We investigated the relationship of DH with breathing pattern and ventilation ((V)over dot(E)) in COPD and normal subjects (NS). In 35 subjects with moderate COPD and 17 younger healthy volunteers we measured inspiratory capacity (IC), breathing frequency (f(R)), expiratory time (T-E), ventilation ((V)over dot(E)) and end-tidal carbon dioxide tension (PETCO2) at baseline and after 30 s of MPT at 40 breaths/min with metronome-defined I:E ratios of 1:1 and 1:2: A reduction in IC (Delta IC) was taken to indicate DH. In COPD subjects, DH correlated with T-E but not with (V)over dot(E) or PETCO2, and was best predicted by total lung capacity. NS also showed DH (although less than in COPD), which correlated with PETCO2 but not with f(R), T-E or (V)over dot(E). We conclude that MPT evokes DH in both NS and patients with COPD. T-E is the most important determinant of DH during MPT in patients with COPD.
Development and validation of a simple risk scoring system for a COVİD-19 diagnostic prediction model
(Tüberküloz ve Toraks, 2023-01-01) Güçlü, Özge Aydın; Ursavaş, Ahmet; Ocakoğlu, Gokhan; Demirdogen, Ezgi; Öztürk, Nilufer Aylin Acet; Topçu, Dilara Ömer; Terzi, Orkun Eray; Onal, Uğur; Dilektaşlı, Aslı Görek; Sağlık, İmran; Coşkun, Funda; Ediger, Dane; Uzaslan, Esra; AkalIn, Halis; Karadağ, Mehmet; AYDIN GÜÇLÜ, ÖZGE; URSAVAŞ, AHMET; OCAKOĞLU, GÖKHAN; DEMİRDÖĞEN, EZGİ; ACET ÖZTÜRK, NİLÜFER AYLİN; ÖMER TOPÇU, DİLARA; TERZİ, ORKUN ERAY; ÖNAL, UĞUR; GÖREK DİLEKTAŞLI, ASLI; SAĞLIK, İMRAN; COŞKUN, NECMİYE FUNDA; EDİGER, DANE; UZASLAN, AYŞE ESRA; AkalIn, Halis; KARADAĞ, MEHMET; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı; 0000-0003-1005-3205; 0000-0002-1114-6051; 0000-0002-7400-9089; 0000-0002-6375-1472; 0000-0001-7099-9647; 0000-0002-2954-4293; 0000-0001-7530-1279; 0000-0002-9027-1132; AAH-5180-2021; A-4970-2019; AAG-8744-2021; AAI-3169-2021; JCO-3678-2023; JPK-7012-2023
Introduction: In a resource-constrained situation, a clinical risk stratification system can assist in identifying individuals who are at higher risk and should be tested for COVID-19. This study aims to find a predictive scoring model to estimate the COVID-19 diagnosis.Materials and Methods: Patients who applied to the emergency pandemic clinic between April 2020 and March 2021 were enrolled in this retrospective study. At admission, demographic characteristics, symptoms, comorbid diseases, chest computed tomography (CT), and laboratory findings were all recorded. Development and validation datasets were created. The scoring system was performed using the coefficients of the odds ratios obtained from the multivariable logistic regression analysis.Results: Among 1187 patients admitted to the hospital, the median age was 58 years old (22-96), and 52.7% were male. In a multivariable analysis, typical radiological findings (OR= 8.47, CI= 5.48-13.10, p< 0.001) and dyspnea (OR= 2.85, CI= 1.71-4.74, p< 0.001) were found to be the two important risk factors for COVID-19 diagnosis, followed by myalgia (OR= 1.80, CI= 1.082.99, p= 0.023), cough (OR= 1.65, CI= 1.16-2.26, p= 0.006) and fatigue symptoms (OR= 1.57, CI= 1.06-2.30, p= 0.023). In our scoring system, dyspnea was scored as 2 points, cough as 1 point, fatigue as 1 point, myalgia as 1 point, and typical radiological findings were scored as 5 points. This scoring system had a sensitivity of 71% and a specificity of 76.3% for a cut-off value of >2, with a total score of 10 (p< 0.001).Conclusion: The predictive scoring system could accurately predict the diagnosis of COVID-19 infection, which gave clinicians a theoretical basis for devising immediate treatment options. An evaluation of the predictive
Diagnostic value of cervical mediastinoscopy: Report of 506 cases
(European Respiratory, 2013-09-01) Erol, Mehmet; Melek, Hüseyin; Bayram, Ahmet; Kermenli, Tayfun; Coşkun, Funda; Akyıldız, Elif; Gebitekin, Cengiz; Erol, Mehmet; MELEK, HÜSEYİN; BAYRAM, AHMET SAMİ; Kermenli, Tayfun; COŞKUN, NECMİYE FUNDA; AKYILDIZ, ELİF ÜLKER; GEBİTEKİN, CENGİZ; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Kliniği; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Patholoji Bölümü; 0000-0003-0684-0900; 0000-0002-7371-4026; 0000-0003-3604-8826; AAE-1069-2022; AAD-1271-2019; AAI-5039-2021; JCE-0097-2023; ABB-7580-2020; KHO-7454-2024; A-6612-2019; IAV-7890-2023
Diagnostic value of video-assisted thoracoscopic lung biopsy on diagnosis of diffuse parenchymal lung dissease
(European Respiratory, 2013-09-01) Bayram, Ahmet Sami; Melek, Hüseyin; Erol, Mehmet Muharrem; Coşkun, Funda; Akyıldız, Elif Ülker; Gebitekin, Cengiz; BAYRAM, AHMET SAMİ; MELEK, HÜSEYİN; Erol, Mehmet Muharrem; COŞKUN, NECMİYE FUNDA; AKYILDIZ, ELİF ÜLKER; GEBİTEKİN, CENGİZ; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Bölümü; 0000-0003-0684-0900; 0000-0003-3604-8826; JCE-0097-2023; AAE-1069-2022; AAI-5039-2021; ABB-7580-2020; AAD-1271-2019; KHE-8874-2024; JHY-9777-2023