Browsing by Author "Knowles, W. D."
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Item Fetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatium(Cleveland Clinic, 1989) Knowles, W. D.; Özmen, Tolga; Korfalı, Ender; Ulus, Hakkı İ.; Uysal, Sait; Uludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.; D-5340-2015Effects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hydroxydopamine injections. The expected dopamine receptor denervation supersensitivity was demonstrated by a 53.7% increase of [3H]spiroperidol binding in rats with sham grafts compared with normal control-group rats. In contrast, rats with grafts showed a significant reduction of supersensitivity, with a 25% decrease in binding to the graft-bearing caudate when compared with the sham-graft group. A nonsignificant 15% decrease in binding on the nongrafted side was also observed. The fetal substantia nigra grafts thus reduced the denervation supersensitivity toward a normal level.Item Non-specific effects of fetal brain grafts on restoration of a cholinergic EPSP in hippocampal slices from fornix lesioned rats(Elsevier Science, 1988) Knowles, W. D.; Korfalı, Ender; Uludağ Üniversitesi.