Fetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatium
Date
1989
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Cleveland Clinic
Abstract
Effects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hydroxydopamine injections. The expected dopamine receptor denervation supersensitivity was demonstrated by a 53.7% increase of [3H]spiroperidol binding in rats with sham grafts compared with normal control-group rats. In contrast, rats with grafts showed a significant reduction of supersensitivity, with a 25% decrease in binding to the graft-bearing caudate when compared with the sham-graft group. A nonsignificant 15% decrease in binding on the nongrafted side was also observed. The fetal substantia nigra grafts thus reduced the denervation supersensitivity toward a normal level.
Description
Keywords
General & internal medicine, Substantia nigra, Animal experiment, Article, Brain graft, Corpus striatum, Fetusat, Nonhuman, Rat, Nonhuman
Citation
Korfalı, E. vd. (1989). ''Fetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatium''. Cleveland Clinic Journal of Medicine, 56(3), 259-262.