Fetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatium

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dc.contributor.authorKnowles, W. D.
dc.contributor.authorÖzmen, Tolga
dc.contributor.buuauthorKorfalı, Ender
dc.contributor.buuauthorUlus, Hakkı İ.
dc.contributor.buuauthorUysal, Sait
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.date.accessioned2021-07-12T11:28:54Z
dc.date.available2021-07-12T11:28:54Z
dc.date.issued1989
dc.description.abstractEffects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hydroxydopamine injections. The expected dopamine receptor denervation supersensitivity was demonstrated by a 53.7% increase of [3H]spiroperidol binding in rats with sham grafts compared with normal control-group rats. In contrast, rats with grafts showed a significant reduction of supersensitivity, with a 25% decrease in binding to the graft-bearing caudate when compared with the sham-graft group. A nonsignificant 15% decrease in binding on the nongrafted side was also observed. The fetal substantia nigra grafts thus reduced the denervation supersensitivity toward a normal level.en_US
dc.identifier.citationKorfalı, E. vd. (1989). ''Fetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatium''. Cleveland Clinic Journal of Medicine, 56(3), 259-262.en_US
dc.identifier.endpage262tr_TR
dc.identifier.issn0891-1150
dc.identifier.issue3tr_TR
dc.identifier.pubmed2568188tr_TR
dc.identifier.scopus2-s2.0-0024934954tr_TR
dc.identifier.startpage259tr_TR
dc.identifier.urihttps://doi.org/10.3949/ccjm.56.3.259
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/2568188/
dc.identifier.urihttp://hdl.handle.net/11452/21221
dc.identifier.volume56tr_TR
dc.identifier.wosA1989U830100008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherCleveland Clinicen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalCleveland Clinic Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGeneral & internal medicineen_US
dc.subjectSubstantia nigraen_US
dc.subjectAnimal experimenten_US
dc.subjectArticleen_US
dc.subjectBrain graften_US
dc.subjectCorpus striatumen_US
dc.subjectFetusaten_US
dc.subjectNonhumanen_US
dc.subjectRaten_US
dc.subjectNonhumanen_US
dc.subject.wosMedicine, general & internaltr_TR
dc.titleFetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatiumen_US
dc.typeArticle

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