Browsing by Author "Ramalingam, Murugan"
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Item Development of silver-based bactericidal composite nanofibers by airbrushing(Amer Scientific Publishers, 2018-04) Bhullar, Sukhwinder K.; Rana, Deept; Özsel, Burçak Kaya; Jun, Martin B. G.; Buttar, Harpal S.; Ostrovidov, Serge; Ramalingam, Murugan; Orhan, Mehmet; Uludağ Üniversitesi/Mühendislik Fakültesi/ Tekstil Müğendisliği Bölümü.; 0000-0001-8043-4148; AAG-8034-2021In this article, we report a simple, cost-effective and eco-friendly method of airbrushing for the fabrication of antibacterial composite nanofibers using Nylon-6 and silver chloride (AgCl). The Nylon-6 is a widely used polymer for various biomedical applications because of its excellent biocompatibility and mechanical properties. Similarly, silver has also been known for their antibacterial, antifungal, antiviral, and anti-inflammatory properties. In order to enhance the antibacterial functionality of the Nylon-6, composite nanofibers in combination with AgCl have been fabricated using airbrush method. The chemical functional groups and morphological studies of the airbrushed Nylon-6/AgCl composite nanofibers were carried out by FTIR and SEM, respectively. The antibacterial activity of airbrushed Nylon-6/AgCl composite nanofibers was evaluated using Gram + ve (Staphylococcus aureus) and Gram -ve (Escherichia coli) bacterial strains. The results showed that the airbrushed Nylon-6/AgCl composite nanofibers have better antibacterial activity against the tested bacterial strains than the airbrushed Nylon-6 nanofibers. Therefore, the airbrushed Nylon-6/AgCl composite nanofibers could be used as a potential antibacterial scaffolding system for tissue engineering and regenerative medicine.Item A facile method for controlled fabrication of hybrid silver nanoparticle-poly (epsilon-caprolactone) fibrous constructs with antimicrobial properties(American Scientific Publishers, 2019-11) Bhullar, Sukhwinder K.; Ruzgar, Duygu Gazioglu; Fortunato, Giuseppino; Aneja, Ginpreet Kaur; Saber-Samandari, Saeed; Sadighi, Mojtaba; Ahadian, Samad; Ramalingam, Murugan; Orhan, Mehmet; Uludağ Üniversitesi/Mühendislik Fakültesi/Tekstil Mühendisliği Bölümü.; 0000-0001-8043-4148; AAG-8034-2021Infection is one of the major factors affecting wound healing. The use of polymeric fibrous constructs or scaffolds with encapsulated biologically active components has shown great potential in topical wound care as wound dressings to expedite wound healing process; however, there is a limitation in precise control over the release of active components. Therefore, in this study, the authors developed a facile method for controlled fabrication of poly(epsilon-caprolactone) (PCL) microfibrous constructs with silver (Ag) nanoparticles as antibacterial agent by single capillary electrospinning. By optimizing spinning parameters, the PCL microfibrous constructs were fabricated. The encapsulation of Ag nanoparticles within the PCL microfibers was confirmed using microstructural analysis. The encapsulation efficacy and release profile of Ag was evaluated in vitro. The diffusion study further revealed the controlled release and optimal bioavailability of Ag during the experimental period. In vitro assessment of antibacterial activity of electrospun hybrid constructs showed a high antibacterial activity and an inhibitory effect on the growth of both staphylococcus aureus and escherichia coli bacteria when compared to PCL and their efficiency of antibacterial activity also varied with respect to the percent of encapsulated Ag nanoparticles. This kind of Ag nanoparticles-loaded PCL microfibrous constructs may be considered for wound care applications.