Browsing by Author "Ulubay, Gaye"

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Effect of asbestos exposure on the frequency of egfr mutations and alk/ros1 rearrangements in patients with lung adenocarcinoma a multicentric study
(Lippincott Williams & Wilkins, 2021-03-01) Yilmaz, Senay; Demirci, Nilgun Yilmaz; Metintas, Selma; Zamani, Adil; Kabalak, Pinar Akin; Yilmaz, Ulku; Ak, Guntulu; Kizilgoz, Derya; Ozturk, Akin; Yilmaz, Ufuk; Batum, Ozgur; Kavas, Murat; Serifoglu, Irem; Unsal, Meftun; Komurcuoglu, Berna E.; Cengiz, Tuba Inal; Ulubay, Gaye; Ozdemirel, Tugce S.; Ozyurek, Berna A.; Kavurgaci, Suna; Alizoroglu, Dursun; Celik, Pinar; Erdogan, Yurdanur; In, Erdal; Aksoy, Asude; Altin, Sedat; Gunluoglu, Gulsah; Metintas, Muzaffer; Karadag, Mehmet; KARADAĞ, MEHMET; Guclu, Ozge A.; AYDIN GÜÇLÜ, ÖZGE; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-0523-7819; 0000-0001-6160-3778; 0000-0002-9027-1132; 0000-0003-1005-3205; 0000-0001-8849-193X; 0000-0002-3445-3804; 0000-0002-2806-4781; 0000-0002-2877-242X; 0000-0003-1596-0082; 0000-0003-0206-7615; 0000-0002-8807-5853; 0000-0002-5609-9658; HKN-2974-2023; HNT-0352-2023; AAS-6628-2021; AAG-9930-2019; AFT-6588-2022; AET-7187-2022; D-2127-2014; JWA-4269-2024; AFP-3587-2022; HLH-3244-2023; C-9348-2014; AAG-8744-2021
Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.
Summary of consensus report on preoperative evaluation
(Bilimsel İpucu Yayınevi, 2015-01-01) Özkan, Metin; Kırkıl, Gamze; Dilektaşlı, Aslı Görek; Söğüt, Ayhan; Sertoğullarından, Bünyamin; Çetinkaya, Erdoğan; Coşkun, Funda; Ulubay, Gaye; Yüksel, Hasan; Sezer, Murat; Özbudak, Ömer; Ulaşlı, Sevinc Sarınç; Arslan, Sulhattin; Kovan, Tezay; GÖREK DİLEKTAŞLI, ASLI; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı; DTT-7416-2022
Turkish thoracic society consensus report: Interpretation of spirometry
(AVES, 2018-11-06) Ulubay, Gaye; Börekçi, Şermin; Akkoca Yıldız, Öznur; Kıyan, Esen; Gemicioǧlu, Bilun; Görek Dilektaşlı, Aslı; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 36466376600
Currently, the criteria for applying and evaluating spirometer measurements have been defined by American and European Respiratory Societies. Several pulmonary function test laboratories in Turkey as well as in the world use these standards. However, different interpretation results are observed in different pulmonary function test laboratories. This report is prepared to provide a basis for a standardized asssessment in our pulmonary function test in our country.
Turkish thoracic society experts consensus report: Recommendations for pulmonary function tests during and after COVID 19 pandemic
(Türk Toraks Derneği, 2020-05-25) Gemicioğlu, Bilun; Börekçi, Şermin; Ulubay, Gaye; Azap, Özlem; Saryal, Sevgi; Dilektaşlı, Aslı Görek; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; CNP-1063-2022; 36466376600
The recommendation of conducting pulmonary function tests (PFTs) from different societies during and after the coronavirus disease (COVID-19) pandemic was rated by the experts of the Turkish Thoracic Society (TTS) and presented as the TTS experts consensus report. Information about the topic has been provided. Globally, as of mid-May 2020, there have been over 4.4 million confirmed cases of COVID-19. There are two main routes of transmission of COVID-19: respiratory droplets and contact transmission. PFTs are non-invasive tests that are commonly performed in routine assessment and follow-up of patients in the pulmonology units. However, PFTs may generate aerosols and require sharing common surfaces. With regard to the high prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the community, PFTs should not be performed routinely in confirmed or suspected patients with COVID-19 during the pandemic. Because of the risk of human-to-human transmission of COVID-19, PFTs should be restricted to a small patient population with selected indications. Triage for COVID-19 should be performed prior to testing. Only essential PFTs such as spirometry, diffusion capacity of the lungs for carbon monoxide (DLCO), arterial blood gas analysis, or pulse oximetry should be performed in the selected cases. Tests should be scheduled to allow sufficient time for donning and doffing of the technical personnel with the full personal protective equipment (PPE) (gown, a filtering respirator mask, goggles or full-face shield, and disposable gloves), ventilation of the room, and application of post-test cleaning and disinfection procedures of the equipment and the testing room.
Understanding the impact of pulmonary rehabilitation on airway resistance in patients with severe copd: A single-center retrospective study
(Dove Medical Press Ltd, 2023-01-01) Kılıç, Lütfiye; Onur, Seda Tural; Ulubay, Gaye; Balcı, Arif; Dilektaşlı, Aslı Görek; GÖREK DİLEKTAŞLI, ASLI; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 0000-0002-5609-0522; 0000-0002-0657-0392; 0000-0001-7099-9647; ABM-3930-2022; ABF-7761-2020
Purpose: We investigated the effect of pulmonary rehabilitation (PR) on airway resistance in chronic obstructive pulmonary disease (COPD) patients with severe airway obstruction and hyperinflation. Patients and Methods: This retrospective cohort study was conducted with data from severe COPD cases with those who underwent an 8-week PR program. Main inclusion criteria were having severe airflow obstruction (defined as a forced expiratory volume in one second (FEV1) <50%) and plethysmographic evaluation findings being compatible with hyperinflation supporting the diagnosis of emphysema (presence of hyperinflation defined as functional residual capacity ratio of residual volume to total lung capacity (RV/TLC) >120%). Primary outcomes were airway resistance (Raw) and airway conductance (Gaw) which were measured by body plethysmography, and other measurements were performed, including 6-minute walk test (6-MWT), modified Medical Research Council dyspnea scale (mMRC) and COPD assessment test (CAT).Results: Twenty-six severe and very severe COPD patients (FEV1, 35.0 +/- 13.1%; RV/TLC, 163.5 +/- 29.4) were included in the analyses, mean age 62.6 +/- 5.8 years and 88.5% males. Following rehabilitation, significant improvements in total specific airway resistance percentage (sRawtot%, p = 0.040) and total specific airway conductance percentage (sGawtot%; p = 0.010) were observed. The post-rehabilitation mMRC scores and CAT values were significantly decreased compared to baseline results (p < 0.001 and p < 0.001, respectively). Although there were significant improvements in 6-MWT value (p < 0.001), exercise desaturation (Delta SaO2, p = 0.026), the changes in measured lung capacity and volume values were not significant.Conclusion: We concluded that PR may have a positive effect on airway resistance and airway conductance in COPD patients with severe airflow obstruction.